Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/64

Click to flip

64 Cards in this Set

  • Front
  • Back
Define seronegative spondyloarthropathies (genetic associations and epidemiology)
Name the 3 diseases in this category
Arthritis without RF
Strong association with HLA B27 (codes for MHC I)
Occurs more in males
Anklyosing spondylitis, Reiter's syndrome, Psoriatic arthritis
Signs/symptoms of ankylosing spondylitis
Chronic inflammatory disease of spine and sacryoiliac joints; stiff spine due to fusion of joints; uveitis and aortic regurgitation seen; bamboo spine on x ray
Associations of anklyosing spondylitis
Inflammatory bowel disease
Classic triad of Reiter's syndrome
(1) conjunctivitis and anterior uveitis
(2) urethritis
(3) arthritis
Possible causative agent to Reiter's?
Chlamydia
Psoriatic arthritis presentation
Joint pain and stiffness associated w/psoriasis; asymmetric and patchy involvement
X ray signs of psoriatic arthritis
Dactylitis (sausage fingers)
"pencil in a cup"
Why do SLE patients have false positives on RPR/VDRL syphilis tests?
Antiphospholipid antibodies cross react w/cardiolipin used in tests
Autoantibodies in SLE and their significance
(1) ANA (sensitive, not specific)
(2) anti dsDNA (very secific, poor prognosis)
(3) anti-Smith (very specific but not prognostic)
(4) antiHistone (drug induced lupus)
Systemic lupus presentation
I'M DAMN SHARP
Ig's (anti dsDNA, anti-Sm, andphospholipid)
Malar rash
Discoid rash
ANA
Mucositis (oropharyngeal ulcers)
Neurological disorders
Serositis (pleuritis, pericarditis)
Hematologic disorders
Arthritis
Renal disorders
Photosensitivity
Sarcoidosis associations
Gammaglobulinemia
RA
ACE increase
Interstitial fibrosis
Noncaseating grabulomas
Why is hypercalcemia seen in sarcoid
Elevated conversion of vitD to its active form in epithelioid macrophages
Signs/sx of sarcoidosis
Restrictive lung disease
Erythema nodosum
Bell's palsy
Hypercalcemia
Uveoparotitis
Polymyalgia rheumatica symptoms
Pain and stiffness in shoulder and hips, often with fever, malaise, wt loss
No muscular weakness
Epidemiology/associations w/polymyalgia rheumatica
Occurs in patients >50YO
Associated with temporal giant cell arteritis
Lab findings in polymyalgia rheumatica
Incr ESR, normal CK
Treatment of sarcoidosis
Steroids
Treatment of polymyalgia rheumatica
Prednisone
Symptoms of polymyositis
Symmetric proximal muscle weakness
Most often in shoulders
Etiology of polymyositis/diagnosis
CD8+ T cell induced injury to myofibers
Muscle biopsy w/evidence of inflammation is diagnostic
Dermatomyositis symptoms
Similar to polymyositis but it is has heliotrope rash
Shawl and face rash
Gottron's papules
Lab findings in polymyositis/dermatomyositisi
Incr CK
Incr aldolase
Positive ANA
Positive Anti-Jo
Associations with dermatomyositis
Incr risk of malignancy
Treatment for dermato/polymyositis
Steroids
Scleroderma
Excessive fibrosis and collagen deposition throughout the body.
Complications of scleroderma
Sclerosis of renal, pulmonary, CV, and GI systems
Diffuse scleroderma
(a) presentation
(b) serum markers
(a) widespread skin involvement, rapid progression, early visceral involvement
(b) anti Scl-70 ab (topisomerase I antibody)
CREST
(a) presentation
(b) serum markers
(a) calcinosis, raynaud's phenomenon, esophgeal dysmotility, sclerodactyly, telangiectasia; limited skin involvement often confined to fingers/face; more benign
(b) anti centromere antibody
Lipoma
(a) gross appearance
(b) treatment
(a) soft, well encapsulated fat tumor (benign)
(b) simple excision usually curative
Liposarcoma
(a) description
(b) treatment
(a) malignant fat tumor that can be large
(b) will recur unless adequately excised
Rhabomyosarcoma
(a) epidemiology
(b) location
(a) most common soft tissue tumor of childhood
(b) arises from skeletal muscle, most often in head/neck
Embryonal rhabdomyosarcoma
(a) description
(b) location
(a) grape like soft polypoid apperance
(b) genitourinary or upper respiratory tract
Define seronegative spondyloarthropathies (genetic associations and epidemiology)
Name the 3 diseases in this category
Arthritis without RF
Strong association with HLA B27 (codes for MHC I)
Occurs more in males
Anklyosing spondylitis, Reiter's syndrome, Psoriatic arthritis
Signs/symptoms of ankylosing spondylitis
Chronic inflammatory disease of spine and sacryoiliac joints; stiff spine due to fusion of joints; uveitis and aortic regurgitation seen; bamboo spine on x ray
Associations of anklyosing spondylitis
Inflammatory bowel disease
Classic triad of Reiter's syndrome
(1) conjunctivitis and anterior uveitis
(2) urethritis
(3) arthritis
Possible causative agent to Reiter's?
Chlamydia
Psoriatic arthritis presentation
Joint pain and stiffness associated w/psoriasis; asymmetric and patchy involvement
X ray signs of psoriatic arthritis
Dactylitis (sausage fingers)
"pencil in a cup"
Why do SLE patients have false positives on RPR/VDRL syphilis tests?
Antiphospholipid antibodies cross react w/cardiolipin used in tests
Autoantibodies in SLE and their significance
(1) ANA (sensitive, not specific)
(2) anti dsDNA (very secific, poor prognosis)
(3) anti-Smith (very specific but not prognostic)
(4) antiHistone (drug induced lupus)
Systemic lupus presentation
I'M DAMN SHARP
Ig's (anti dsDNA, anti-Sm, andphospholipid)
Malar rash
Discoid rash
ANA
Mucositis (oropharyngeal ulcers)
Neurological disorders
Serositis (pleuritis, pericarditis)
Hematologic disorders
Arthritis
Renal disorders
Photosensitivity
Sarcoidosis associations
Gammaglobulinemia
RA
ACE increase
Interstitial fibrosis
Noncaseating grabulomas
Why is hypercalcemia seen in sarcoid
Elevated conversion of vitD to its active form in epithelioid macrophages
Signs/sx of sarcoidosis
Restrictive lung disease
Erythema nodosum
Bell's palsy
Hypercalcemia
Uveoparotitis
Polymyalgia rheumatica symptoms
Pain and stiffness in shoulder and hips, often with fever, malaise, wt loss
No muscular weakness
Epidemiology/associations w/polymyalgia rheumatica
Occurs in patients >50YO
Associated with temporal giant cell arteritis
Lab findings in polymyalgia rheumatica
Incr ESR, normal CK
Treatment of sarcoidosis
Steroids
Treatment of polymyalgia rheumatica
Prednisone
Symptoms of polymyositis
Symmetric proximal muscle weakness
Most often in shoulders
Etiology of polymyositis/diagnosis
CD8+ T cell induced injury to myofibers
Muscle biopsy w/evidence of inflammation is diagnostic
Dermatomyositis symptoms
Similar to polymyositis but it is has heliotrope rash
Shawl and face rash
Gottron's papules
Lab findings in polymyositis/dermatomyositisi
Incr CK
Incr aldolase
Positive ANA
Positive Anti-Jo
Associations with dermatomyositis
Incr risk of malignancy
Treatment for dermato/polymyositis
Steroids
Scleroderma
Excessive fibrosis and collagen deposition throughout the body.
Complications of scleroderma
Sclerosis of renal, pulmonary, CV, and GI systems
Diffuse scleroderma
(a) presentation
(b) serum markers
(a) widespread skin involvement, rapid progression, early visceral involvement
(b) anti Scl-70 ab (topisomerase I antibody)
CREST
(a) presentation
(b) serum markers
(a) calcinosis, raynaud's phenomenon, esophgeal dysmotility, sclerodactyly, telangiectasia; limited skin involvement often confined to fingers/face; more benign
(b) anti centromere antibody
Lipoma
(a) gross appearance
(b) treatment
(a) soft, well encapsulated fat tumor (benign)
(b) simple excision usually curative
Liposarcoma
(a) description
(b) treatment
(a) malignant fat tumor that can be large
(b) will recur unless adequately excised
Rhabomyosarcoma
(a) epidemiology
(b) location
(a) most common soft tissue tumor of childhood
(b) arises from skeletal muscle, most often in head/neck
Embryonal rhabdomyosarcoma
(a) description
(b) location
(a) grape like soft polypoid apperance
(b) genitourinary or upper respiratory tract