Usmle Step 1 Fa Muscoluskeletal Muscle And Ct Disease

Front 1

Becker muscular dystrophy
Inheritance pattern

Back 1

XLR
Can be spontaneous

Front 2

Becker muscular dystrophy
Clinical presentation

Back 2

Milder muscular dystrophy
Patients may walk until 20-25
Cardiac lesions mild

Front 3

Duchenne muscular dystrophy: inheritence pattern and genetic defect

Back 3

X linked
Abnormal dystrophin protein loss of membrane stablity

Front 4

Becker muscular dystrophy
Inheritance pattern

Back 4

XLR
Can be spontaneous

Front 5

Becker muscular dystrophy
Clinical presentation

Back 5

Milder muscular dystrophy
Patients may walk until 20-25
Cardiac lesions mild

Front 6

Duchenne muscular dystrophy: inheritence pattern and genetic defect

Back 6

X linked
Abnormal dystrophin protein loss of membrane stablity

Front 7

Duchenne muscular dystrophy presentation

Back 7

Pelvic girdle weakness and ataxia w/progressive course
Pseudohypertrophy of calves
Children unable to walk by age 10

Front 8

Complications of duchenne muscular dystrophy

Back 8

Myocardial involvement may cause death

Front 9

Heterozygous female carriers of duchenne muscular dystrophy

Back 9

May have subclinical degeneration of muscle fibers

Front 10

Faciocapulohumeral muscular dystrophy inheritence

Back 10

AD
Spontaneous mutation common

Front 11

Faciocapulohymeral muscular dystrophy presentation

Back 11

Weakness begins in pelvic or shoulder girdle; may retain ambulation for 25y

Front 12

Myotonic dystrophy inheritence and genetic defect

Back 12

AD or spontaneous
Trinucleotide repeat in protein kinase

Front 13

Myotonic dystrophy clinical presentation

Back 13

Weakness, atrophy, myotonia
Head and neck muscles frequently weak and atrophic

Front 14

Myasthenia gravis etiology

Back 14

Autoimmune disease; Abs against neuromuscular junction acetylcholine receptors (nicotinic AchR)

Front 15

Myasthenia gravis presentation

Back 15

Typically young women
Fluctuating weakness but no sensory abnormalities and worsens with increased use

Front 16

Diagnosis of myasthenia gravis

Back 16

Decremental respones on EMG or improvement w/edrophonium (AchEI)

Front 17

Associations w/myasthenia gravis

Back 17

May have thymic abnormalities, including thymoma or thmynic hyperplasia

Front 18

Myositis ossificans

Back 18

Pain, swelling and tenderness
Ossification at site of traumatic hemorrhage

Front 19

Lambert Eaton Syndrome etiology

Back 19

Autoantibodies to presynaptic Ca2+ channels cause decr Ach release

Front 20

Lambert Eaton syndrome presentation

Back 20

Proximal muscle weakness
Symptoms improve with use
No reversal of symptoms with AchEI alone

Front 21

Presentation of mixed connective tissue disease

Back 21

Raynaud's phenomenon, arthralgias, myalgias, fatigue, esophageal hypomotility

Front 22

Serum markers for mixed CT disease

Back 22

Antibodies to U1RNP

Front 23

Treatment of mixed CT disease

Back 23

Responds to steroids