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10 Cards in this Set
- Front
- Back
Neutrophil chemotaxis cytokines/molecules
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IL-8, C5a, leukotrience B4 (endothelial damage) , fibrinopeptides (from endothelial damage), formyl methyionyl peptides (released from microorganisms)
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Histamine
(a) source (b) effects during inflammation (c) triggers for release |
(a) basophils, mast cells, platelets
(b) vasodilation, increased vascular permeability |
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Serotonin
(a) source (b) effects (c) triggers for release |
(a) platelets
(b) vasodilation and increased vascular permeability (c) platelet aggregation |
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Thromboxane A2
(a) produced by what enzyme? (b) effect? |
(a) cylcooxygenase (arachadonic acid product)
(b) vasoconstriction and platelet aggregation (made by platelets) |
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Prostacylin (PGI2)
(a) produced by what enzyme? (b) effect? |
(a) cyclooxygenase (arachadonic acid product)
(b) vasodilation and inhibits platelet aggregation (made by vascular endothelium) |
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PGE2
(a) produced by what enzymes? (b) effect? |
(a) cyclooxygenase (arachadonic acid product)
(b) pain |
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PGE2, PGD2, PGF2
(a) produced by what enzyme? (b) effect? |
(a) COX (arachadonic acid product)
(b) vasodilation |
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LTB4
(a) produced by what enzyme? (b) effect? |
(a) lipooxygenase
(b) neutrophil chemotaxis, increased vascular permeability, vasoconstriction or vasodilation |
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LTC4, LTD4, LTE4
(a) produced by what enzyme? (b) effect? |
(a) lipooxygenase
(b) bronchoconstriction, increased vascular permeability, vasoconstriction or dilation (tissue specific-constriction in kidney and heart and vasodilation in skin and nasal mucosa) |
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Bradykinin
(a) describe production (b) effect (c) degraded by? |
(a) Hageman factor (XII) converts prekallikrein to kallikrein which converts kininogen to bradykinin
(b) increased vascular permeability, pain, vasodilation, bronchodilation (c) various peptidases including angiotensin converting enzyme |