Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
15 Cards in this Set
- Front
- Back
|
Diagnosis of AIDs
|
HIV+ w/CD4<200 OR HIV+ w/ an AIDS defining illness
|
|
|
Diagnosis of HIV
|
ELISA
Western blot confirmation |
|
|
Monitoring of HIV
|
CD4 count
HIV 1 RNA viral load by PCR |
|
|
NRTI's
(a) mechanism (b) Name the most common drugs of this class |
(a) Nucleoside reverse transcriptase inhibitors ; converted to active forms by phosphorylation. Prevent conversion of viral RNA to dsDNA. Some cross resistance.
(b) Zidovudine (ADV), Didanosine (ddl), Zalcitabine (ddC), stavudine (d4T), Lamivudine (3TC) |
|
|
Zidovudine
(a) class/mechanism (b) Side effects and comments |
(a) NRTI (inhibits reverse transcriptase)
(b) Used in HAART and in prophylaxis following needlesticks or to prevent maternal/fetal transmission. Bone marrow suppression (dose limiting and may require transfusions) |
|
|
Didanosine
(a) class/mechanism (b) Side effects and comments |
(a) NRTI (inhibits reverse transcriptase)
(b) Pancreatitis (dose limiting) |
|
|
Zalcitabine
(a) class/mechanism (b) Side effects and comments |
(a) NRTI (inhibits reverse transcriptase)
(b) peripheral neuropathy |
|
|
Stavudine (d4T)
(a) class/mechanism (b) Side effects and comments |
(a) NRTI (inhibits reverse transcriptase)
(b) peripheral neuropathy |
|
|
Lamivudine (3TC)
(a) class/mechanism (b) Side effects and comments |
(a) NRTI (inhibits reverse transcriptase)
(b) fewer side effect (mild GI distress, headache). Also used to treat hepB |
|
|
NNRTI's
(a) mechanism (b) major drugs of this class |
(a) inhibit reverse transcriptase but don't require metabolic activation; no cross resistance.
(b) Nevirapine, Delavirdine, Efavirenz |
|
|
Nevirapine
(a) class/mechanism (b) Side effects and commonets |
(a) NNRTI (inhibits reverse transcriptase)
(b) prevents maternal/fetal transmission |
|
|
Delavirdine
(a) class/mechanism (b) Side effects and comments |
(a) NNRTI (inhibits reverse transcriptase)
(b) major drug interactions and possible teratogen |
|
|
Efavirenz
(a) class/mechanism (b) side effects and comments |
(a) NNRTI (inhibits reverse transcriptase)
(b) major drug interactions, possible teratogen |
|
|
Protease inhibitor
(a) mechanism (b) major drugs in this class (c) major side effects |
(a) inihibition of aspartate protease a pol gene product; prevents viral assembly
(b) Indinavir, Ritonovir, Saquinavir, Nelfinavir, Amprenavir, Lopinavir (c) GI distress, hyperglycemia, hyperlipidemia, altered fat distribution, nephroplithiasis (maintain hydration, indinavir), thrombocytopenia (indinavir) |
|
|
Fusion inhibitors
(a) mechanism (b) major drug in this class |
(a) binds gp41 preventing fusion of viral and cellular membranes
(b) enfuvirtide |
