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76 Cards in this Set
- Front
- Back
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Procainamide
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SLE-like syndrome
Arrhythmias |
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Tocainide
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Pulmonary fibrosis
Neutropenia |
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Amiodarone
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Cutaneous photosensitivity (due to Iodine deposition in skin/cornea
Hyper or hypothyroidism Pulmonary fibrosis Prolonged QT interval |
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Statins
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Elevated LFTs
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Niacin
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Hyperuricemia
Flushing - pretreat with ASA Can potentiate the effect of anti-hypertensives, leading to postural hypotension; decrease dose of HTN medication Can be associated with insulin resistance |
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Fibrates
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Cholelithiasis
Myositis |
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Ace inhibitors
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Dry cough
Angioedema Hypotension Hyperkalemia Reversible renal failure (in the case of bilateral renal artery stenosis) |
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Drugs that cause a lupus-like syndrome
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Hydralazine
Isoniazid Procainamide |
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Digitalis
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Arrhythmia
Altered color perception Headache Confusion Blurred vision |
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Risperidone
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Hyperprolactinemia
Amenorrhea secondary to elevated prolactin |
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Thiazolidinediones
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Hepatotoxicity
Fluid retention and aggravation of CHF Osteopenia, risk of fractures |
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Protease inhibitors
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Lipodystrophy
Hyperglycemia P450 inhibition CNS disturbances |
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Amantidine
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CNS disturbances
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Foscarnet
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Nephrotoxicity
Hypocalcemia Hypomagnesemia Hypokalemia |
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Ganciclovir
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Neutropenia
Thrombocytopenia Nephrotoxicity |
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Oral metronidazole
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Disulfram-like effects
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Halogenated inhaled anesthetics
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Fulminant hepatic necrosis (2-4d post surgery)
Malignant hypertension |
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Trazodone
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Priapism (TrazaBONE)
Postural hypotension |
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Zidovudine
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BM suppression
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Acetaminophen
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Hepatotoxicity
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Methotrexate
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Myelosuppression
GI Hemorrhagic enteritis |
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Diphenhydramine
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Sedation
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Cyclosporine
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Nephrotoxicity
Hyperkalemia |
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Tacrolimus
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Peripheral neuropathy
Nephrotoxicity |
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Azathioprine
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Myelosuppression
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Spirinolactone
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Hyperkalemia
Acidosis Gynecomastia |
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Metronidazole
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Disulfram-like reaction with ethanol
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Fluoroquinolones
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Decreased bioavailability with antacids
Achilles tendon rupture Cartilage damage in children |
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Doxorubicin
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Cardiomyopathy (due to limited SOD in cardiac tissue)
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Bleomycin
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Pulmonary fibrosis
Hypertrophic skin changes Hyperpigmentation of hands |
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Cyclophosphamide
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Myelosuppression
Hemorrhagic cystitis |
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Vincristine
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Peripheral neuropathy
SIADH |
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Trastuzumab
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Congestive heart failure
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Rituximab
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Hypotension
Bronchospasm Angioedema |
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Cisplatin
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Nephrotoxicity
Ototoxicity |
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Tacrine
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Hepatotoxicity
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Loop diuretics
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Hypocalcemia
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Tamoxifen
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Endometrial hyperplasia
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Verapamil
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AV Nodal block
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Amlodipine
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Peripheral edema
Reflex tachycardia |
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Chronic low dose ASA
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Peptic ulcer disease
GI bleeding |
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Clozapine
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Agranulocytosis
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Ziprasidone
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Prolonged QT Interval
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Aminoglycosides
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Nephrotoxicity
Ototoxicity |
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Vancomycin
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Red man syndrome due to histamine release
Nephrotoxicity Ototoxicity Neutropenia/Thrombocytopenia |
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Amphotericin B
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ATN
Decreased GFR Hypokalemia Hypomagnesemia |
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Norepinephrine
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Tissue necrosis at injection site
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Thionamides (PTU & methimazole)
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Agranulocytosis
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Statins
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Hepatotoxicity
Myopathies |
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Thiazide diuretics
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Hypokalemia
Hyponatremia Hyperuricemia Orthostatic hypotension Hypercalcemia Hyperglycemia (in diabetics) Elevated serum LDL and cholesterol |
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Loop diuretics
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Ototoxicity (esp. in conjunction with aminoglycosides)
Hyperuricemia Acute hypovolemia Hypokalemia Hypomagnesemia |
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Spironolactone
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Hyperkalemia
Androgen-like effects |
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Carbamazepine
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BM suppression
Dyscrasias Hepatotoxicity SIADH SJS |
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Ticlopidine
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Neutropenia
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Heparin
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Hemorrhage
Thrombosis (in chronic use due to decreased ATIII) HIT types 1 and 2 (type 2 associated with Heparin-PF4 antibodies) |
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Warfarin
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Hemorrhage
Drug interactions |
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Ethambutol
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Optic neuritis and color blindness
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Phenytoin
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Gingival hyperplasia
Lymphadenopathy Ataxia, nystagmus Megaloblastic anemia (interferes with folate absorption in gut) P450 inducer |
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Valproate
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Hepatotoxicity
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Lamotrigine
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Stevens-Johnson syndrome
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Mercaptopurine
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Cholestasis
Hepatitis |
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SSRIs
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Sexual dysfunction
Sleep disturbance Serotonin syndrome |
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Mirtazapine
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Sedation
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Trazadone
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Priapism
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Nefazodone
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Hepatotoxicity
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TCAs
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Muscarinic effects:
-Blurred vision -Xerostomia -Urinary retention -Constipation -Decreased cardiac conduction (overdose risk) -Aggravation of narrow angle glaucoma Adrenergic effects: -Orthostatic hypotension -Dizziness -Reflex tachycardia Histaminic: -Sedation Other: -Weight gain |
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MAOIs
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Food-Drug interactions (due to decreased tyramine metabolism)
Orthostatic hypotension Blurred vision Dry mouth Dysuria Serotonin syndrome -allow 2wk washout period; 6wk washout with fluoxetine |
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Lithium
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Ataxia
Tremors/convulsions Hypothyroid Sedation Dermatologic reactions Ebstein's anomaly from in utero exposure |
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Isoniazid
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Lupus-like syndrome
Peripheral neuritis (due to relative B6 deficiency) Hepatotoxicity |
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Rifampin
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Hepatotoxicity
Flu-like Sx |
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Rifabutin
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Uveitis
Skin hyperpigmentation Neutropenia |
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Pyrazinamide
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Urate retention and gout
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Ethambutol
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Optic neuritis
Red-green color blindness |
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Dapsone
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Hemolysis (esp. among G6PD deficient individuals)
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Sulfonylureas
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Weight gain
Hyperinsulinemia Hypoglycemia Disulfram-like effects |
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Metformin
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Lactic acidosis (esp. with beta-blockers)
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