Usmle Immunology

Front 1

This cytokine is secreted by macrophages IL-1

Back 1

IL-6

Front 2

This cytokine causes leukocyte recruitment

Back 2

vascular leak TNF

Front 3

TCR

Front 4

Bruton's: BBB (B cells

Back 4

Bacterial infections

Front 5

Pro B cells express Tdt

Back 5

MHC II

Front 6

Pre B cells express Cytoplasmic º+

Back 6

MHC II

Front 7

(NOTE: the Cytoplasmic º+ is the recombinated heavy chain

Back 7

the surface receptor (IgM) needs the light chain in order to be expressed at the surface. Immature B cells represent that next step in development)

Front 8

Immature B cells express Surface IgM+

Back 8

MHCII

Front 9

Mature B cells express: Surface IgM

Back 9

IgD

Front 10

2. They neither express

Back 10

TCR

Front 11

B and T cells--Severe Combined immunodef (SCID) Defect in early stem-cell differention. Present with recurrent viral

Back 11

bacterial

Front 12

Defect in CD40L on CD4z T helper cells leasd to inability to class switch. Presents early in life w/ severe pyogenic infections. High levels of IgM

Back 12

very low levels of IgG

Front 13

Presents with coarse Facies

Back 13

cold (noninflamed) staphylococcal Absesses

Front 14

Presents w/ recurrent pyogenic infections by staph and strep

Back 14

partial albinism and peripheral neuropathy

Front 15

Defect in microbicidal activity of Neutrophils owing to lack of a key enzyme (or similar enzymes) presenting w/ marked susceptibility to opportunistic infections with bacteria

Back 15

esp S aureus & E. coli as well as Aspergillus

Front 16

IL-1 is secreted by:

Back 16

Secreted by macrophages.

Front 17

This cytokine causes acute inflammation

Back 17

IL-1

Front 18

This cytokine induces chemokine production to recruit leukocytes

Back 18

IL-1

Front 19

This cytokine actives endothelium to express adhesion molecules

Back 19

IL-1

Front 20

This cytokine is an endogenous pyrogen

Back 20

IL-1

Front 21

This cytokine is secreted by Th cells

Back 21

IL-2

Front 22

This cytokine stimulates growth of helper and cytotoxic T cells

Back 22

IL-2

Front 23

This cytokine is secreted by activeated T cells

Back 23

IL-3

Front 24

This cytokine supports the growth & differentiation of bone marrow stem cells

Back 24

IL-3

Front 25

This cytokine has a function similar to GM-CSF

Back 25

IL-3

Front 26

This cytokine is secreted by Th2 cells

Back 26

IL-4

Front 27

This cytokine promotes growth of B cells

Back 27

IL-4

Front 28

This cytokine enhances class switching to IgE (and IgG ?)

Back 28

IL-4

Front 29

This cytokine is secreted by Th2 cells

Back 29

IL-4 and IL-5

Front 30

This cytokine promotes differentiation of B cells

Back 30

IL-5

Front 31

This cytokine enhances class switching to IgA

Back 31

IL-5

Front 32

This cytokine stimulates production and activation of eosinophils

Back 32

IL-5

Front 33

This cytokine is secreted by Th cells and macrophages

Back 33

IL-6

Front 34

This cytokine stimulates production of acute-phase reactants and immunoglobulins

Back 34

IL-6

Front 35

This cytokine is secreted by macrophages

Back 35

"IL-1

Front 36

This cytokine is a major chemotactic factor for neutrophils

Back 36

"IL-8

Front 37

This cytokine is secreted by regulatory T cells

Back 37

IL-10

Front 38

This cytokine inhibits actions of activated T cells

Back 38

IL-10

Front 39

This cytokine is secreted by B cells and macrophages

Back 39

IL-12

Front 40

This cytokine activates NK and Th1 cells

Back 40

IL-12

Front 41

This cytokine is secreted by Th1 cells

Back 41

Interferon-gamma

Front 42

This cytokine stimulates macrophages

Back 42

IFN-gamma

Front 43

This cytokine is secreted by macrophages

Back 43

TNF

Front 44

This cytokine mediates septic shock

Back 44

TNF

Front 45

This cytokine causes leukocyte recruitment

Back 45

vascular leak

Front 46

""Hot T-Bone stEAk""

Back 46

""IL1: Fever (Hot)"

Front 47

Helper T Cell Surface Proteins

Back 47

"CD4

Front 48

CT Cell Surface Proteins

Back 48

"CD8

Front 49

TCR

Front 50

B Cell Surface Proteins

Back 50

"IgM

Front 51

Macrophage Cell Surface Proteins

Back 51

"MHC II

Front 52

NK Cell Surface Proteins

Back 52

"Receptors for MHC I

Front 53

Cell Surface Protein in all cells except RBCs

Back 53

MHC I

Back 54

""X-linked recessive defect in BTK Tyrosine Kinase assoc w/ low levels of all classes of immunoglobulins. ⬇ # of B cells. 1. Assoc w/ recurrent Bacterial infections after 6 mo of age. "

Front 55

Bruton's: BBB (B cells

Back 55

Bacterial infections

Front 56

Primary Lymphoid organ sites include:

Back 56

Bone Marrow & Thymus

Front 57

Secondary Lymphoid organs include and are sites of ________

Back 57

"These include:

Front 58

2. What are the stages?

Back 58

""1. Bone Marrow"

Front 59

Pro B cells express

Back 59

""Tdt

Front 60

Pre B cells express

Back 60

""Cytoplasmic μ+

Front 61

(NOTE: the Cytoplasmic μ+ is the recombinated heavy chain

Back 61

the surface receptor (IgM) needs the light chain in order to be expressed at the surface. Immature B cells represent that next step in development)"

Front 62

Immature B cells express

Back 62

""Surface IgM+

Front 63

Mature B cells express:

Back 63

""Surface IgM

Front 64

2. What molecules are expressed?

Back 64

""1. Bone Marrow but mature in the Thymus"

Front 65

2. They neither express

Back 65

TCR

Front 66

(DiGeorge syndrome)

Back 66

Thymus and parathyroids fail to develop owing to failure of development of 3rd and 4th pharyngeal pouches. Present with Tetany owing to hypocalcemia. Recurrent viral and fungal infections due to T-cell deficiency. Congenital defects of heart and great vessels 22q11 deletion"

Front 67

B and T cells--Severe Combined immunodef (SCID)

Back 67

""Defect in early stem-cell differention. Present with recurrent viral

Front 68

Name the disease

Back 68

""IL-12 receptor deficiency"

Front 69

Name the disease

Back 69

""Hyper IgM syndrome"

Front 70

Defect in CD40L on CD4⁺ T helper cells leasd to inability to class switch. Presents early in life w/ severe pyogenic infections. High levels of IgM

Back 70

very low levels of IgG

Back 71

""Wiskott-Aldrich Syndrome"

Front 72

Name the disease

Back 72

""Job's Syndrome"

Front 73

Presents with coarse Facies

Back 73

cold (noninflamed) staphylococcal Absesses

Front 74

Name the Disease

Back 74

Leukocyte Adhesion Deficiency (CD18=LFA-1 integrin def in phagocytes)"

Front 75

Presents w/ recurrent pyogenic infections by staph and strep

Back 75

partial albinism and peripheral neuropathy

Front 76

Name the Disease

Back 76

""Chédiak-Higashi Syndrome"

Front 77

Defect in microbicidal activity of Neutrophils owing to lack of a key enzyme (or similar enzymes) presenting w/ marked susceptibility to opportunistic infections with bacteria

Back 77

esp S aureus & E. coli as well as Aspergillus

Front 78

Name the Disease

Back 78

""CGD=Chronic Granulomatous Disease d/t lack of NADPH oxidase enzyme or related enzymes"