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27 Cards in this Set
- Front
- Back
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Two bacteria with superantigens
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Staph aureus
Strep pyogenes |
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S. aureus superantigen
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-TSST-1
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S. aureus toxin that causes food poisoning
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enterotoxin
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S. aureus toxin that causes staphylococcal scalded skin syndrome
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exfoliatoxin
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4x bacteria with adp ribosylating A-B toxins
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C. diphtheriae
V. Cholerae E. coli B. pertussis |
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This toxin produced by S. pyogenes causes a toxic shock like syndrome (scarlet fever)
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erythrogenic toxin
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mechanism of C. diphtheriae toxin?
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-adp ribosylating A-B toxin
-inactivates EF2 |
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mechanism of P. aeruginosa exotoxin A?
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-adp ribosylating A-B toxin
-inactivates EF2 |
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2 bacteria whose toxins inactivate EF2
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-C. diphtheriae
-P. aeruginosa |
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mechanism of V. cholerae toxin?
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+adenylyl cyclase --> inc Cl- into gut, dec Na absorption --> H2O into gut lumen --> diarrhea
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a. which bacterium possesses labile/stabile toxins?
b.What is the mech of labile and stable toxins? |
a. ETEC
b. "Labile like the AIR, Stable like the GROUND." -LT: stimulates adenylyl cyclase -ST: stimulates guanylyl cyclase Action of both causes watery diarrhea ("Traveler's diarrhea") |
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mechanism of Bordetella pertussis toxin?
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inhibits Gi --> inc cAMP
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six bacteria whose toxins are cAMP inducers
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1. V. cholerae
2. B. pertussis 3. E. coli (labile toxin) 4. B. anthracis (edema factor) 5. C. jejuni 6. B. cereus |
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mechanism: C. perfringens toxin
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lecitinase --> cleaves cell membranes
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mechanism: C. tetani toxin
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blocks release of GABA/glycine (inhibitory NTR) in Renshaw cells in spinal cord
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mechanism: C. botulinum toxin
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cleaves neuroexocytosis apparatus --> blocks ACh release --> paralysis
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mechanism of shiga toxin
(Shigella) |
cleaves host cell rRNA --> inactivation of 60S ribosome
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mechanism of shiga-like toxin
(EHEC) |
cleaves host cell rRNA --> inactivation of 60S ribosome
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What is the action of Streptolysin O?
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-S. pyogenes
-hemolysin |
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What is the action of an ADP ribosylating toxin?
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permanently activates endogeneous proteins through addition of ADP ribosyl group
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Viridans streptococci produce _____ that allow them to adhere to ______, which is why they can infect damaged heart valves
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-dextrans
-fibrin |
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which virus families can undergo reassortment? (x4)
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"ReAssortment Brings Out" bad disease
Reo (includes Rota) Arena Bunya Orthomyxo (prototype) |
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which bacterial toxin causes increased sensitivity to histamine?
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pertussis toxin
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grp A streptococci resist phagocytosis via this virulence factor
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M protein
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this extracellular enzyme produced by S. pyogenes disintegrates PMNs and their neutrophil extracellular traps (NETs), allowing it to move more freely in tissues
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DNase
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what is the function of S. aureus' virulence factor Protein A?
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Protein A binds Fc portion of Ig's --> impaired fixation of complement --> dec phagocytosis
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What is the mechanism of a superantigen?
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Crosslinks MHC receptors and TCR's indiscriminately --> nonspecific activation of large #s of T cells --> toxic shock syndrome
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