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20 Cards in this Set
- Front
- Back
Cyclosporine
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80. Protects against rejections from organ transplants 81. Does not induce bone marrow depression
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Cyclophosphamide
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82. Alkylating agent of both purine & pyrimidine bases of DNA 83. Txt CLL
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Cisplatin’s toxicities
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84. Nephro- & Ototoxicity
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Methotrexate
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85. Antimetabolite of folic acid: (-)dihydrofolate reductase
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Leucovorin Rescue
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86. Can block/reduce Methotrexate = increases folic acid via a reduced folate
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Bleomycin toxicities
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87. Pneumonitis & pulmonary fibrosis
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Azathiorine
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88. Used in organ transplantation = kidney allografts 89. Allopurinol can increases its activity by (-) its biotransformation to xanthine oxidase
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MOPP
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90. Chemotherapy used in the txt of Hodgkin’s disease 91. M = Mechlorethamine – nitrogen mustard 92. O = Oncovin (Vincristine) – prevents microtubule assembly 93. P = Procarbazine 94. P = Prednisone – glucocorticoid, inducing apoptosis
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Tamoxifen
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95. (-) estrogen receptor 96. Txt of breast tumors, can see associated endometrial CA
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Flutamide
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97. Antiandrogenic 98. Used w/ Leuprolide (LH-RH analog) 99. Txt prostatic CA
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Megestrol
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100. (-) progesterone receptor 101. Txt endometrial CA
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Fluoxymesterone
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102. Androgenic steroid
103. Txt mammary CA in postmenopausal women |
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Methotrexate
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104. Folic acid analog that (-) tetrahydrofolate synthesis by (-) dihydrofolate reductase 105. Txt of ALL 106. Txt of Psoriasis
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Brain tumor Txt
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107. Lomustine 108. Carmustine – Causes pulmonary fibrosis
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Streptozocin
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109. Attaches to β cells 110. Txt of pancreatic insulinomas
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Cytarabine (AraC)
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111. Pyrimidine analog 112. DOC for AML
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Dactinomycin
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113. Used for Wilms tumor & rhabdomyosarcoma
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Etoposide
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114. Used for oat cell CA
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Paclitaxel
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115. Used for ovarian CA
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Amifostine
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116. Can ↓ nephrotoxicity due to chronic use of Cisplatin
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