Usmle 1 Pharm Ca

Front 1

Catalyzes the activation of antithrombin III to decrease thrombin and Xa

Uses (2)

site of action?

Back 1

Heparin


Uses:
Immediate anticoagulation
(PE, MI, stroke, DVT),
Used during pregnancy (does not cross)

site: Blood

Front 2

Interferes w/ factors II, VII, IX and X and protein C and S

Use

site of action?

Back 2

Warfarin

use:
Chronic coagulation

[the EX-PaTriot went to WAR]
EXtrinsic-PT pathway

site: Liver

Front 3

drug class that aids in conversion of plasminogen to plasmin (which cleaves thrombin and fibrin clots)

name (4)

Back 3

Thrombolytics

Streptokinase,
Urokinase,
tPA (alteplase),
Antistreplase

Front 4

what inhibits plasminogen to plasmin?

Back 4

Aminocaproic acid

Front 5

what glycoprotein in platelet binds to exposed collagen?

which bind together to aggregate?

Back 5

to collagen: GP-1a


together: GP-IIb/IIIa

Front 6

The only irreversible binder in the group to inhibit COX-1 and COX-2

Back 6

Aspirin

Front 7

drug inhibits platelet binding by irreversibly blocking ADP receptors, thereby inhibiting fibrinogen binding by preventing GP-IIb/IIIa expression

(2) uses

AE?

Back 7

Clopidogrel

use:
Acute Coronary syndrome,
Coronary stenting

AE:
Neutropenia
(tiCLOPidine)

Front 8

drug that binds directly to GP-IIb/IIIa on activated platelets, preventing aggregation

use?

Back 8

Abciximab


use:
Angioplasty

Front 9

S-phase specific anti-cancer drugs
(5)

Back 9

Methotrexate,
5-FU,
Cytarabine,
6-MP,
Hydroxyurea

Front 10

S-phase antimetabolite that inhibits DHF reductase resulting in low dTMP

(2) AE?

Back 10

Methotrexate


AE:
Myelosuppression,
Macrovesicular fatty liver

Front 11

what reduces the myelosuppression toxicity in Methotrexate?

Back 11

Leucovorin

Front 12

S-phase pyrimidine analog that inhibits thymidylate synthase, resulting in low dTMP

(3) uses

(2) AE

Back 12

5-Fluorouricil (5-FU)

uses:
Colon CA,
solid tumors,
Basal cell CA

AE:
Myelosuppression,
photosensitivity

Front 13

S-phase that blocks Purine synthesis and is activated by HGPRTase

(2) uses?

what can increase toxicity?

Back 13

6-Mercaptopurine (6-MP)

use:
Leukemias (not CLL)
Lymphomas (not Hodgkin)

inc Toxicity: Allopurinol
(metabolized by Xanthine Oxidase)

Front 14

S-phase tha inhibits DNA polymerase to compete w/ dCTP

use?

(3) AE

Back 14

Cytarabine (ARA-C)

use: AML

AE:
Leukopenia,
Thrombocytopenia,
Megaloblastic anemia

Front 15

Alkylating agent covalently x-link DNA at guanine N-7

use (3)

AE

Back 15

Cyclophosphamide

use:
Non-Hodgkins lymphomas,
Breast CA,
Ovarian CA

AE:
hemorrhagic CYSTITIS

Front 16

Alkylating agent class that crosses BBB

name drugs (2)

AE

Back 16

Nitrosoureas

drugs:
"-MUSTINE"
Streptozocin

AE:
CNS toxicity (dizzy, ataxia)

Front 17

(2) anti-cancer drugs that act like Alkylating agents and form free radicals; they cause AE of Ototoxicity and Nephrotoxicity

use (4)

Back 17

Cisplatin, Carboplatin

use (BOLT):
Bladder CA,
Ovarian CA,
Lung CA,
Testicular CA,

[BOLT ON the PLAnTation]

Front 18

Alkalaying agent of DNA used as DOC for CML

(2) AE

Back 18

Busulfan

AE:
Pulmonary fibrosis,
hyperpigmentation

Front 19

(2) anti-cancers that generates free radicals and noncovalently intercalate in DNA (breaking strands); AE include cardiotoxicity

(2) uses

another AE

Back 19

Doxorubicin (Adriamycin),
Danorubicin

use:
Hodgkins (A in ABVD combo)
solid tumors

AE:
Alopecia

Front 20

another name for:

Doxorubicin

Back 20

Adriamycin

Front 21

what anti-cancer drug that intercalates in DNA, is used for childhood tumors?

Back 21

ACTinomycin-D

[children ACT out]

Front 22

drug that induces formation of free radicals to cause breaks in DNA; AE is pulmonary fibrosis

(2) uses

Back 22

Bleomycin

use:
Testicular CA,
Hodgkins (B in ABVD combo)

Front 23

G2-specific agent that inhibits Topoisomerase-II

(3) uses

Back 23

EToPoSide (VP-16)

uses:
T: Testicular CA,
P: Prostate CA,
S: Small cell CA of lung

Front 24

MC glucocorticoid in cancer therapy

(2) uses

aside from usual corticoid AE (cushings, osteoporosis) what other AE?

Back 24

Prednisone

use:
Hodgkins (P in MOPP combo)
CLL

AE:
cataracts

Front 25

monoclonal Ab against HER-2 (erb-B2)--Breast CA

AE

Back 25

Trastuzumab (HERceptin)

AE:
Cardiotoxicity

Front 26

monoclonal Ab against the Philadelphia chromosome brc-abl tyrosine kinase

Back 26

Gleecec (Imatinib)

Front 27

M-phase specific alkaloids that bind to tubulin and block polymerization of microtubules so that spindle fibers cannot form

use (3)

AE (2)

Back 27

Vincristine ("Oncovin"); Vinblastine

use:
Hodgkins (O in MOPP combo),
Wilm's Tumor,
Choriocarcinoma

AE:
Vincristine - Neurotoxicity
Vinblastine - BLASTs bone marrow

Front 28

M-phase specific that bind to tubulin and hyperstabilize polymerized microtubules so that spindle fibers cannot breakdown (anaphase cant occur)

use (2)

AE (2)

Back 28

Taxols (Paclitaxel)

use:
Ovarian CA
Breast CA

AE:
myelosuppression,
Hypersensitivity

Front 29

what are the drugs in the ABVD Hodgkins combo?

Back 29

Adriamycin (doxorubicin),
Bleomycin,
Vinblastine,
Dacarabazine

Front 30

what are the drugs in the MOPP Hodgkins combo?

Back 30

Mechlorethamine
Oncovoin (Vincristine)
Prednisone
Procarbazine

Front 31

DOC for CLL

Back 31

Prednisone

Front 32

DOC in CML
(2)

Back 32

Gleevac,

Busulfan

Front 33

DOC in AML

Back 33

Cytarabine

Front 34

anti-cancer drug that causes Pancreatitis

Back 34

Asparaginase

Front 35

anti-cancer drug that causes oral and GI ulcers

Back 35

5-FU

Front 36

which ant-cancer drugs are clasified as Alkylating agents?
(4)*

Back 36

"at NITe the CYCLOne picked-up the BUS and CAR"

NITrosureas,
CYCLOphosphamide,
BUSulfan,
CARboplatin, cisplatin

Hint 36

at NITe the CYCLOne picked-up the BUS and CAR

Front 37

what anti-cancer drug works in the G-0 phase?

Back 37

Busulfan

Front 38

which anti-cancer drugs generate free radicals?
(3)*

Back 38

BAD radicals:

Bleomycin,
Actinomycin-D,
Doxorubicin, Daunorubicin

Hint 38

BAD radicals

Front 39

(2) drugs that work in the G-2 phase

Back 39

Bleomycin,

Etoposide (VP-16)