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30 Cards in this Set
- Front
- Back
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What do endothelial cells of peritubular capillaries synthesize and secrete?
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Erythropoietin
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What part of the nephron is involved in hydroxylation of 25-OH vitamin D3 to 1,25 OH2 D3
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proximal tubules
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What cell type may be used to resist cahnges in volume and prssure?
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Mofibroblasts
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90-95% of the blood passing through the kidney can be found where?
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corex
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What is a nephron?
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Renal corpuscle and all its ducts
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Are the renal columns of Bertin part of the cortex or the medulla?
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They are extensions of the cortex in between the pyramids, but since they're in the medulla area, they are part ofthe medulla.
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Is lobulation obvious in adult kidneys?
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No, only in fetal and then disappears in adult
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Right before the collecting duct reaches the papilla of the medulla, what does the name change to?
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Papillary duct (of Bellini)
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Area cribrosa is the perforated part of the papilla where the collecting ducts come out into the minor calyx
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What is the primary component of the filtration barrier?
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Glomerular basal lamina
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What part of the filtration apparatus can be stained with PAS?
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glomerular basal lamina
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What is the space in between neighboring pedicles called?
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Slits. This is where blood leaks out into the urinary space.
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podocytes
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What helps regulate the size of the filtration slits?
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Actin filaments of the podocytes
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How does ultrafiltrate (blood) reach the slits?
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The capillaries are highly fenestrated so it leaks through their into slits into urinary space.
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3 components of filtration apparatus
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lacis cells
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mesangial cells that are outside of the corpuscle. part of the juxtaglomerular appartatus
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Macula densa: cells in the wall of the distal tubule
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JG cells: modified cells in AFFERENT arterioles. Contain secretory granules full of renin.
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Blood pressure regulation
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How does the PCT reabsorb amino acids and sugars?
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Microville have ATPAses, peptidases and disacchardases which breakdown the peptids and sugars and then they get reabsorbed using ATPases.
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What kind of nephrons have the longest loops?
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Justamedullary nephorns
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Nephorns with shortest loops?
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Cortial nephrons
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Cell types vary according to length of loop in the thin part.
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Reabsorption and secretion
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collecting duct
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what type of cells in collecting tubules use ATP dependnt pumps to secrete H+ into the lumen?
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alpha intercalated cells (type of dark cell)
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What type of aquaporin do light cells use that is responsible for H20 permeability?
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AQP2
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Where does the vasa recta lie?
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medulla
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Mesangial cells outside of the renal corpuscle along the vascular pole
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lacis cells. form part of the juxtaglomerular apparatus
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