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11 Cards in this Set
- Front
- Back
What kind of molecules are receptors? Where are they found?
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Protein molecules. Mostly on the plasma membrane, but also some in the nuclear membrane.
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What are the typical shapes of dose-response curves and log dose-response curves?
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A plateauing curve and sigmoidal, respectively.
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What is the ED50 of a drug?
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The dose that will produce a defined response in half of the population.
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What is the TD50 of a drug?
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The dose that will produce a defined toxic response in half the population.
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What is the problem with giving higher doses to overcome lower potency?
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Higher doses also provide a higher chemical load and toxicities.
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How do you calculate the therapeutic index of a drug?
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TI = TD50 / ED50.
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What are some different effects that can be had by an antagonist?
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Interaction with a receptor without stimulation or transduction, prevention of the effects of an agonist, and responses elicited due to preventing the action of an agonist.
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What is a full agonist? Do they all give the same curve?
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A drug that gives a maximal response (efficacy of 1). They can vary in affinity, though, shifting the curve right as affinity decreases.
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What does the curve of a partial agonist/antagonist look like compared to a full agonist?
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Shifted right and sloped more to the right.
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What is a competitive antagonist? What is its effect on the D/R curve?
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It combines with the same receptor as the agonist. It shift the curve right, but still parallel to the full agonist.
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What kind of shift of D/R curve does an irreversible agonist promote? What if the dose is increased?
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It shifts it right, and angling more to the right. This is increased when dosage is increased.
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