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29 Cards in this Set
- Front
- Back
Leukemoid Reaction
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Exaggerated WBC response to infection; usually due to infection
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Leukoerythroblastic Reaction
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Marrow infiltrative disease; peripheralizes myeloblasts/nucleated RBC
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Esosinophilia
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Type I hypersensitivity (penicillin reaction); invasive helminthic infection
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Helminths NOT producing eosinophilia
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Pin worms; adult worms in ascariasis
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Atypical lymphocytes
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Mononucleosis; CMV; toxoplasmosis; viral hepatitis; phenytoin
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Mononucleosis
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EBV; EBV attaches to CD21R on B cells
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Clinical findings mono
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Exudative tonsillitis; generalized lymphadenopathy; hepatosplenomegaly
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Lab findings mono
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Atypical lymphocytosis; IgM heterophile antibodies against horse RBCs
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Lymphopenia
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T cell deficiencies (HIV); combined B/T deficiency (adenine deaminase deficiency)
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Lymphocytosis causes
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Viral Infections, whooping cough
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Causes of leukoerythroblastic reaction
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Bone metastasis MCC; myelofibrosis
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Corticosteroids
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Lymphoenoia, eosinopenia, neutrophilia
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Chronid MPD
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Neoplastic stem cell disorder; splenomegaly; marrow fibrosis; risk for leukemia
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Examples of MPD
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Polycythemia vera, myelofibrosis and myeloid metaplasia
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Acute vs Chronic Leukemia
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Acute: blasts > 20% in BM or PB
Chronic: blasts < 10% in BM |
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Myelofibrosis myeloid metaplasia
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Marrow fibrosis; etramedullary hematopoisesis; splenomegaly
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Lab findings in myelofibrosis
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Tear drop RBCs; drop bone marrow aspirate (marrow fibrosis)
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Myelodysplastic Syndrome
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Severe anemia in elderly; 30% develop leukemia; ringed sideroblasts
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Benzene
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aplastic anemia; acute leukemia
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Leukemias by Age
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ALL: newborn-14
AML: 15-60 CML: 40-60 CLL: >60 |
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AML
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Auer rods in myeloblasts
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Acute Monocytic Leukemia
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Gum infiltration
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CML
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t(9;22) of bcr-abl; Philadelphia chromosome 22; decreased leukocyte alpkaline phosphatase score
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ALL
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early pre-B(80%); CALLA (CD10) and Tdt positive; CNS and testicle involvement
t(12;21) offers good prognosis |
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CLL
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B cell neoplasm; decreased gamma globulins; MCC generalized lymphadenopathy patients >60 yrs old
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Adult T cell Leukemia
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HTLV-1; CD4 T cells; skin infiltration; lytic bone lesions with hypercalcemia
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Stomach Cancer Metastasizes where
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Left supraclavicular nodes (Virchow node)
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Phenytoin
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Atypical lymphocytosis
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Cat scratch Disease
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Bartonella henselae; granulomatous microabscesses
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