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8 Cards in this Set
- Front
- Back
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enterocromaffin-like cells |
-lie deep in the oxyntic glands -secrete histamine in response to gastrin -can also be stimulated by hormones secreted by the enteric nervous system |
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killing H pylori |
Triple therapy -PPI (omeprazole) -ampicillin -clarithromycin or metronidazole (if penicillin allergic the clarithomycin AND metronidazole |
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Histamine blockading drugs |
-reduce gastric acid by reducing the stimulation of oxyntic cells via the histamine pathway -permits ulcer healing -CIMETIDINE - first drug discovered -RANITIDINE - better safety profile |
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Cimetidine |
-H2 blocker -orally ->60% bioavailability -half life 2 hours -renal excretion -adverse effects: dizziness, cyt P450 inhibitor, affects hormone metab. leading to galactorrhea and gynaecomastia -interferes with tricyclines and serotonin reuptake inhibitors |
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Ranitidine |
-OCT, similar indications to cimetidine -well absorbed orally 50% -half life 2-25 h -renal excretion -adverse effects: malaise, dizziness, liver toxicity, INCREASED RISK OF GI INFECTION |
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Omeprazole |
inhibits K+/H+ pump by binding irreversibly adverse effects: -CNS:headache, dizziness -respiratory: Upper tract infections, cough -GI: abdominal pain, diarrea, nausea, constipation etc -neuromusuclar: back pain, weakness -dermatologic: rash |
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If previous exposure to and penicillin allergy |
PPI bismuth metronidazole tetracycline alternative antibiotics: fluoroquinolones |
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managing peptic ulcer disease |
-reducing damage to the mucosal surfaces: dietary advice, atacids, bismuth -killing H pylori -reducing gastric acids: PPI, H2 blockers |
