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8 Cards in this Set
- Front
- Back
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3 drugs to avoid using with Mycophenolate |
Antacids (use H2 and PPI) Cholestyramine Calcium Polycarbophil |
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What metabolise Cyclosporine, Tacrolimus,Sirolimus and Everolimus |
All are substrate for 3A and P-GP Except Everolimus, they also inhibits 3A and P-gO |
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What 2 azoles should not be used with sirolimus? |
Ketoconazole, Voriconazole Increase AUC of sirolimus by 11 fold |
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How to adjust the dose of CNI with Voriconazole? |
Decrease cyclosporine dose by 50% Decrease tacrolimus dose by 67% |
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How to adjust the dose of CNI with Intraconazole? |
Decrease cyclosporine and tacrolimus dose by50% |
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2 notes about fluconazole with CNI |
Dose-dependent interactions 100 mg/day: minimal to no effect oncyclosporine concentrations >100: 1.4 fold 200: 3.1 fold Intravenous fluconazole has less interactionthan oral fluconazole |
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What to avoid with Azathioprine |
Allopurinol |
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What vaccine to avoid with Immunosuppressives |
Live vaccines |
