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459 Cards in this Set
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drug class, moa, brand name cyclophosphamide?
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Class: alkylating agent
MOA: forms strog bondds w/ DNA inhibiting replication & causing cell death BRAND: CYTOXAN |
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ADRs of cyclophosphamide (CYTOXAN)? PC?
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leukopenia, delayed N/V, alopecia, D, mucosititis
RARE: hemorrhagic cystitis, sterility PC-D |
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DFs cyclophosphamide (cytoxan)
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powder for inj 100, 200, 500 mgs, 1 & 2 g
25, 50 mg tablets |
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indications cyclophosphamide (cytotoxan)?
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oncologic: hodgkin's/non-hodgkin's, CLL, AML, AL, neuroblastoma, breast, testicular, ovarian, lung, BMT
non-oncologic: prophylaxis organ rej, RA, MS, nephrotic syndrome, hemolytic anemia, granulomatosis, myasthenia gravis |
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adult dose cyclophosphamide (cytoxan)
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PO 60-120 mg/m2/day up to 14 days
IV 500-1500mg/m2 Q 21-28 days HIGH DOSE: 1.8 g/m2/day x 4 days |
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dosage adj cyclophosphamide (cytoxan)?
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for crCL, high bili, high asT
don't administer with bili > 3mg/dl |
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D-D intrxns of cyclophosphamide (CYTOXAN)?
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phenobarb, pheytoin incr metabl of cytoxan: prolonged leukopenia w/ thiazide diuretics; activation inhibited w/ cimetidine; dig levels decr, prolonged succinylcholine act
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brand name, clas, moa of doxorubicin?
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ADRIAMYCIN, RUBEX
CLASS: anthracycline MOA; inhibition DNA/ RNA synt |
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DF, PC, CIs doxorubicin (Adriamycin, Rubex)?
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Df: 10, 20, 50,150 mg pow 4 inj
PC-D, absolute CI-congestive HF, sever hepatic dysfun |
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ADRs if doxorubicin (adriamycin, rubex)?
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leukopenia, mucosititis, N?V, alopeica, anemia
rare?severe- cardiotox, vesicant, radiation recall |
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indications of doxorubicin (adriamycin, rubex)?
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breast cancer, leukemias, lymphomas, multiple myeloma, sarcomas, testicular/bladder/uterine/head/neck/
tyroid/stomach cancers, neuroblastoma, mesotheliomas |
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dosing/dose adj for doxorubicin (adriamycin, rubex)?
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adult: 30-75 mg/m2 q 3-4 weeks;
20-30 mg/m2/day for 3 days q3-4 weeks; 30-60 mg/m2/day days 1 & 8 q 3-4 weeks bladder lavage: 30-100 mg/m2/week adj clcr<10, high bili don't give with bili>5 |
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d-d intrxns of doxirubicin ( adriamycin, rubex)?
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cyclosporine incr levels, paclitaxel reduces CL, dig & phemytion levels decr
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How do u treat extravasation of doxirubicn(adriamycin, rubex)?
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topical DMSO & cold compress
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brand, class, MOA 6-mercaptopurine (6-MP)?
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Brand: purinethol
class: antimetabolite (purine antag) MOA: acts as purine antag, incorp into DNA/RNA preventing replication |
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dfs, indications, dosing of 6-MP (PURINETHOL)?
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DFs: 50 mg tab
indications: ALL, non-hodgkin's induction: 2.5-5 mg/kg/day; 80-100 mg/m2/d mainten: 1.5-2.5 mg/kg/d RENAL ADJ |
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adrs, CIs, PC, of 6-MP (PURINETHOL)?
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leukopenia, THROMBOCYTOPENIA, anemia, HEPATOX,DRUG FEVER, HYPERPIGMENTATION, N
PC-d CI in severe liver DX |
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Drug intrxns of 6-mp (purinethol )?
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allopurinol incr 6mp level by 75%
warfarin effects inhib |
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drug class of cytoxan (cyclophphosphamide)?
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alkalating agent pc-d
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common adr of cyclophosphamide (cytoxan)?
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alopecia, mucositis, delayed N/V, leukopenia,
(severe hemorrhagic cystitis -rare) |
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Se of doxorubicn (adriamycin, rubex)?
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cardiotoxicity
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CI of doxorubicin (adriamycin, rubex)?
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CHF, severe hepatic dysfunction
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What to recommend if extravasation occurs w/ doxirubicin (adriamycin, rubex)?
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topical DMSO and cold compress
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DF of 6MP (purinethol)?
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50 mg tab
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ADR of 6MP (PURINETHOL)?
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leukopenia, thrombocytopenia, anemia, hepatotox, N, drug fever, hyperpigmentation
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What drug does 6MP have an effect on?
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warfarin
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Indication of methotrexate (FOLEX, RHEMATREX, MEXATE)?
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RA
(also psoriasis, glucocorticoid-dependent asthma, ectopic pregnancy, cancers:breast, lymphoma, ALL, head/neck,etc) |
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class of cisplatin (platinol)?
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platinum, bitches
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common adr of paclitaxel (TAXOL)?
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bradycarida, peripheral neuropathies, myalgias
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max dose of apap?
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4 g/day linit to 2g/d chronic alkies
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does ultram (tramadol) cause serotonin syndrome?
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Y
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does ultram (tramadol) cause serotonin syndrome with MAOI?
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YEP
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Brand name Fetanyl?
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DURAGESIC
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DF Fetanyl (duragesic)?
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25,50,75, 100 mcg/hr patch
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initial dose fentanyl (duragesic)?
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25 mcg/hr q 72 hrs
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absolute ci of oxycodone (oxycotin, roxicodone, oxy ir,, oxyfast)?
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acute or severe asthma, paralytic ileus
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Common ADR oxycodone?
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dizziness, constipation, N/V< SEVERE RESP DEPRESSION
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PC of oxycodone?
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b/d
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generic name of vicodin, lorcet, lortab, norco)?
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hydrocodone/apap
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DF of morphine (astramorph, oramorph, MS contin, kadian, avinza, roxanol, msir, duramorph)?
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tab: 15, 30 mg
tab cr: 15, 30, 60,100, 200 mg cap cr: 10,30,50, 60, 100 mg cap: 15, 30 mg |
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generic name of endocet, oxycet, percocet, toxicet, tylox?
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oxycodone/apap
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common adr of endocet?
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sedation, dizziness, constipation, N/V, xerostomia, pruritis
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drugs affecting oxycodone/apap?
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CNS depressants, TCAS
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indication of celebrex (celecoxib) COX-2 inhibitor?
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OA 200 mg/d
RA 100-200 mg BID |
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absolute CI of celebrex?
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hypersensitivity to sulfonamides, severe renal dx
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fluconazole increases the conc of celebrex?
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YES
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DF Of EXCEDRIN IB (ibuprofen)?
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OTC: 100, 200 mg tab &
100mg/ 5ml susp RX: 400, 600, 800 mg T & 40mg/ml drops |
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Indication of nabumetone (RELAFEN)?
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acute tmt of mild-mod pain, acute tmt gout, acute/chronic RA
|
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Maintenance & max dose nabumetone (RELAFEN)?
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1 g daily MAX 2 g daily
for all indications |
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Commonm ADR of nabumetone (RELAFEN)?
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GI upset, epigastric pain, rash, fluid retention, TINNITUS, ulceration
SEVERE: agranulocytosis, angioedema, CHF, hepatitis, SJS |
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What drugs worsen nephrotoxicty w/ nabumetone (RELAFEN)?
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CSA or TAC
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What is the initial & max dose of naproxen (NAPROSYN) for analgesia, fever, dysmenorrhea?
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initial: 500 mg daily, the 250 mg q 6-8 hours
max: 1200 mg/d |
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What antidiabetic agent decr hepatic glucose production, dec intestinal absorption of glucose and incr glucose uptake and utilization?
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metformin (GLUCOPHAGE)
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Severe ADR of metformin (GLUCOPHAGE)?
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lactic acidosis, megaloblastic anemia
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What is the initial and max dose of metformin (GLUCOPHAGE) for T1DM?
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INITIAL: 500 mg BID w/ AM & PM grub or 850 QD w/ am grub or
500 mg ER w/ PM grub MAX: 2550 mg/d (850 mg T) 2500 mg/d (500 mg T) |
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Absolute CI of Glucophage (metformin)?
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men Scr > 1.5
women Scr > 1.4 CHF, metabloic acidosis |
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What is METAGLIP?
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glipizide/ metformin )SU/BG
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What is GLUCOVANCE?
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glyburide/ metformin (SU/BG
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MOA of insulin?
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decreases BG by stimulating peripheral glucose uptake while decr hepatic glucose production
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Indication of Insulin?
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Type I, II DM, severe DKA, hyperkalemia tmt
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How to prevent lipodystrophy for using insulin?
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rotate inj site
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Initial dose of NPH for type I and II DM?
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0.5-1 unit/kg/day
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Draw regular insuling into syringe first and then add the NPH to the solution?
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YES
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Generic name of Humalog?
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LISPRO (0.5-1 unit/kg/d 15 min b4 meals)
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Dosage form of Amaryl (glimepiride)?
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1,2,4 mg tab
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Is AMARYL (glimepiride ) contraindicated in type 1 DM?
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Yes as are all SU
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Drugs affecting pioglitazone (ACTOS)?
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ETOH (hypoglycemia), CYP 3A4 inhibitors incr effect, ketoconazle incr effect, CYP 3A$ inducers decr effect, OC decr effectiveness of ACTOs
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Initial dose of AVANDIA (rosiglitazone)?
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4 mg/ day
max is 8 mg/d |
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Generic name of NEOSPORIN?
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neomycin/polymycin B
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Common ADR of INH (isoniazid, LANIAZID, NYDRAZID)?
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peripheral neuropathy, increase LFT, ab pain, HEPATITIS
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Is rifampin (RIFADIN, RIMACTANE) a broad spectrum enzyme inducer?
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YES (der!)
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Max dose of sildenafil (VIAGRA)?
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100 mg/day
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Sever AdR of sildenafil (VIAGRA)?
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priapism (painful erection)
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Absolute CI of sildenafil (VIAGRA)?
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concomitant nitrates
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Indication of cyclosporine (NEORAL, GENGRAF, SANDIMMUNE)?
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Prevent transplant rejection, RA, psoriasis
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Counseling pt about CSA?
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avoid GF juice as it incr CSA (NEORAL, GENGRAF, SANDIMMUNE) levels
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SANDIMMUNE & NEORAL BE?
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NO-NEORAL AND GENGRAF ARE
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verapamil and diltiazme incr cyclosporine blood levels?
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YES
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what effect does folic acid have on cyclosporine (sandimmune, neoral, gengraf)?
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decreases the effect of CSA
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Usual and max dose of loratadine (CLARITIN) for 2-6 Y) w/ allergic rhinitis, urticaria?
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5 mg QD for both usual and max
>6 YO 5-10 mg QD |
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Indication of Mupirocin (BACTROBAN) ointment?
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impetigo
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Indication of Metronidazole (METROGEL 0.75% topical gel?
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inflammatory papules & pustules of rosacea
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usual dose of DURAGESIC (Fentanyl)?
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25-400 mcg/hr q 72 hours
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SE of Duragesic (FENTANYL)?
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constipation, N/V, dizziness
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morphine ( ORAMORPH, MS CONTIN, KADIAN, AVINZA, MSIR) is CIII?
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NOOO
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SE of Morphine?
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constipation, N/V, dizziness, dry mouth
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Oxycontin is CIII ?
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noooooo
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Dose of Nabumetone (RELAFEN)?
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1000-2000 mg/day in divided doses (500 mg BID)
max is 2g/day |
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Nabumetone(RELAFEN) an NSAID?
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why, YESSSSS
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severe ADR OF metformin (GLUCOPHAGE)?
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lactic acidosis
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Dose of glyburide (DIABETA, MICRONASE)?
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2.5-5 mg/day
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Decreases hypoglycemic effect of insulin?
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antivirals, OCs, phenytoin
not ACEI |
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PC of OCs?
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X
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SE of OCs?
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edema, breast tenderness, HTN
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CI of OCs?
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MI, breast cancer, undiagnosed abnl genital bleeding
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|
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Prempro (Premphase) is?
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conjugated estrogen and medroxyprogesterone
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Prempro (premphase) SE?
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vaginal bleeding, breast tenderness, weight gain, HA,
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MOA of KEFLEX (cephalexin)?
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inhibits bacterial cell wall growth
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Dose of Claritin (loratidine)?
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10 mg/d (5-10 mg/d)
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Dose of dopamine (INOTROPIN) IV?
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1-5 mcg/kg/min
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indications of KLONOPIN (clonazepam)?
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PANIC DISORDER & ABSENCE SEIZURES
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Indication of BUSPAR (buspirone)?
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ARENT U GLAD ITS GAD!!
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Dose of ZERIT (stavudine)?
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> or = 60 kg 40 mg BID
<60 kg 30 mg BID |
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Dose of stavudine (ZERIT)?
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40 mg BID if at least 60 kg
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Indication of alteplase (ACTIVASE)?
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acute MI, stroke, pulmonary embolism
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trade name of itraconazole?
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SPORANAX
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Indication of Valacyclovir (VALTREX)?
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herpes zoster and genital herpes
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dose of bezapril (LOTENSIN) for HTN?
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10 mg/day
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dose of benzapril (LOTENSIN) for HTN?
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10 mg/d
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Initial & maintenance dose of losartan (COZAAR)?
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INITIAL 50 mg/d
MAINTENACE 25-100 mg/d in 1-2 div doses |
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losartan (COZAAR) absolutely CI in pregnancy?
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No, but recommend DC asap (PC-C 1st trim, D 2-3 trim)
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Common ADR of digoxin (LANOXIN, DIGITEK)?
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HA, N, D dizziness, anorexia
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Severe ADR of DIGITEK (LANOXIN, digoxin)?
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AV tach, AV disassociation, heart block, ventricular fib, anxiety, BLURRED OR YELLOW VISION, hallucination, gynecomastia
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Which drugs cause sig decline in glomerular filtration or tubular secretion w/ digoxin?
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aminoglycosides & amphotercin
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drugs that increase dig levels?
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AMIODARONE, CSA, CLARITHROMYCIN, ITRACONAZLE, & diazepam, indomethacin, propafenone, quinidine, tetracyclines, alpraz, verap, spironolactone
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When do you check dig levles?
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check serum levels just b4 the next dose or >=6-8 hours after the last dose (0.8-2ng/ml)
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Maintenance dose of TENORMIN (atenolol) for HTN?
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50-100 mg QD
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Max dose of metoprolol (LOPRESSOr) for HTN?
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450 mg/day
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Absolute CI of metoprolol (LOPRESSOR, TOPROL XL)?
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3rd degree AV block, sinus bradycardia, cardiogenic shock, overt cardiac failure
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Dosage form of diltiazem (TIAZAC, CARTIA XT, DILACOR XR, CARDIZEM (CD/SR)?
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tablets, capsules, injectables
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Common ADR of diltiazem (TIAZAC, CARTIA XT, DILACOR XR, CARDIZEM)?
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peripheral edema, hypotension, flushing, HA, bradycardia, asthenia (loss of strength)
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common ADR of furosemide (LASIX)?
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hyponatremia, hypokalemia, hypochloremic alkalosis, HA, D, orhtostasis
SEVERE: ototoxicity |
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Common ADR of IMDUR (ISMO, MONOKET, isosorbide mononitrate)?
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severe HA (also flushing, potural hypotension, lightheadedness, weakness, insomnia, tachycardia/palpitations, syncope)
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Absolute CI of IMDUR (ISMO, MONOKET, isosorbide mononitrate)?
|
cerebral hemorrhage, recent head trauma, pericardial tamponade, constrictive pericarditits
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Indication of IMDUR (MONOKET, ISMO, isosorbide mononitrate)?
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prophylaxis & long-term maintenance of angina
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IMDUR (MONOKET, ISMO, isosorbide mononitrate) effect on sildenafil?
|
YES-INCREASE HYPOTENSIVE EFFECT
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Common ADR of dopamine (INOTROPIN)?
|
hypotension (also ectopic beats, N,V, angina, dyspnea, HA, vasoconstriction)
|
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Absolute CI of dopamine (INOTROPIN)?
|
pheochromocytoma, uncorrected tacyarrhythmias, v fib
|
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Dopamine (INOTROPIN) decreases effectiveness of TCAs?
|
YES
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Max PO dose of sumatriptan (IMITREX)?
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200 mg QD
(inj is 12mg SC QD) |
|
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Common ADR of sumatriptan (IMITREX)?
|
parasthesias, hot/cold skin sensations, flushing, fatigue, somnolence, photosensitivity,( N, dry mouth HA)
|
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Absolute CI to IMITREX (sumatriptan)?
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ischemic heart dx, angina, CVA, TIA, MI, uncontrolled HTN, use of another 5HT1 agonist w/in 24 hr, ergotamine use, DO NOT USE MAOIS WITHIN 2 WEEKS OF IMITRREX TX
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Initial dose of XANAX (alprazolam) for GAD?
|
0.25-0.5 mg TID
|
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Maintenance dose of KLONOPIN (clonazepam) for panic disorder?
|
1-2 mg/day
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Initial dose of diazepam (VALIUM) for anxiety disorder?
|
6-15 mg/day
MAX dose 40 mg/day |
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Initial dose of BUSPAR (buspirone) for GAD?
|
10-15 mg/day in 2-3 divided doses
|
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Indication for carbamazepine (ATRETOL, CARBATROL, EPITOL, TEGRETOL (XR))?
|
seizures
|
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Treatment for reaction of amphotercin B?
|
benadryl and APAP (infuse over at least 2 hours)
|
|
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Initial & maintenance dose of gabapentin (NEURONTIN)?
|
initial 300 mg TID
maintenance 900-1800 mg QD adjusting for renal function |
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Common ADR of gabapentin (NEURONTIN)?
|
CNS: fatigue, somnolence, dizziness, NYSTAGMUS, ataxia
|
|
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Aluminum containing antacids decrease the bioavail of gabapentin?
|
YES BY UP TO 20%
|
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Dosage form of divalproex (valproic acid, DEPAKENE, DEPACON, DEPAKOTE/ER)?
|
tablet, er tablert, capsule (syrup & inj too)
|
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Mainten dose of mirtazapine (REMERON) for depression?
|
15-45 mg/day (max is 45 mg/day renal adj)
|
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Absolute CI to REMERON (mirtazapine)?
|
concomitant use of MAOi
|
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Severe ADR of nefazodone (SERZONE) for depression?
|
BB warning HEPATOTOX
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Common ADR of trazodone (DESYREL)for depression?
|
tachycardia at high doses (also seen w/ buproprion), sedation, dizziness, dry mouth (anticholinergic ses), (wt gain)
|
|
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Indication of fluoxetine (PROZAC, SARAFEM)?
|
depression, OCD, bulimia, PMDD
|
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max dose of SARAFEM (fluoxetine)?
|
80 mg/day
|
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common ADR of fluoxetine (SARAFEM, PROZAC)?
|
GI, sexual dysfuntion, insomnia, appetite suppression w/prozac, sedation or sleeplessness
(RARE/SEvere=hyponatremia & SIADH) |
|
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Initial dose of paroxetine (PAXIL)?
|
20 mg/day except for panic disorder 10 mg/day
|
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Indication of PAXIL (paroxetine 10, 20,30,40 mg t)?
|
depression, OCD, panic disorder, social anxiety disorder, GAD, PTSD
|
|
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Initial dose of ZOLOFT (sertraline) for OCD, depression?
|
50 mg/day
max dose 200 mg/day |
|
|
MOA of ZYPREXA (olanzapine) for schizophrenia, acute mania?
|
dopamine, 5HT2 max dose 30 mg/day
|
|
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SE of RISPERDAL (risperidone)?
|
may prolong QT interval, orhtostatic HTN, EPS, NMS
|
|
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Initial dose of donepezil (ARICEPT)?
|
5 mg PO Q HS
|
|
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Common ADR of donepezil (ARICEPT)?
|
well its a cholinesterase inhibitor for dementia so cholinergic ses: N/V/D, tachycardia, dizziness, headache
|
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Drugs affecting donepezil (ARICEPT)?
|
cholinergic agents additive effect; anticholinergics decrease effect
|
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MOA of BZPS?
|
FACILITATE GABA
|
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Temezepam's effect on other drugs?
|
CNS depressants additive CNS depression
|
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indication of cyclobenzaprine (FLEXERIL) and DF?
|
relief of muscle spasm
DF 10 mg tab |
|
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Cyclobezaprine (FLEXERIL) effect on drugs?
|
CNS depressants-additive CNS depression and MAOIs CNS rxn
|
|
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Dose of ADDERALL (amphetamine/dextroamphetamine?
|
>6 YO w/ ADD 5 mg/day (Increase 5 mg/day weeekly intervals)
|
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Indication of tamoxifen (NOLVADEX)?
|
reduction in breast cancer incidence in high risk women
|
|
|
Common ADR of tamoxifen (NOLVADEX)?
|
hot flashes, vaginal discharge, vaginal bleeding, menstrual irregularities
|
|
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indication of alendronate (FOSAMAX)?
|
treatment/ prevention of osteoporosis
|
|
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Dosing of alendronate (fosamax) for prevention & treatment of osteoporosis?
|
Prevention 5 mg/ day or 35 mg/week
tmt 10 mg/day or 70 mg/week |
|
|
DF of calcitonin (MIACALCIN)?
|
200 IU/activation nasal spray
|
|
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Common ADR of MIACALCIN (calcitonin)?
|
allergic rxn, nasal mucosal alteration, rhinitis
|
|
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DF of ESTRACE (estradiol)?
|
0.5, 1, 2 mg tablets
|
|
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Common ADR of ESTRACE (estradiol)?
|
breast tenderness, N/V, vaginal bleeding
|
|
|
DF of CLIMARA (VIVELLE, ESTRADERM, estradiol TDS)?
|
Vivelle & climara 0.025, 0.05, 0.075. 1 mg/day patch
(estraderm comes in 0.05 & ! mg patch only) |
|
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Indication of CLIMARA (VIVELLE, ESTRADERM, estradiol TDS)?
|
prevention of post-menopausal osteoporosis, tmt of vasomotor symptoms and vulvar/ vaginal atrophy
|
|
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Dose of PROVERA (CYCRIN, DEPO-PROVERA, medroxyprogesterone) for secondary amenorrhea?
|
5-10 mg/day for 5-10 days
|
|
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Dose of EVISTA (raloxifene) for prevention/tmt of postmenopausal osteoporosis?
|
60 mg/day
|
|
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DF, PC, Max dose of lovastatin (MEVACOR, ALTOCOR)?
|
10, 20, 40 mg tab
all HMGCoA inhibitors PC-X and max dose of all is 80 mg/day!!! |
|
|
Max dose of tolterodine (DETROL) for overactive bladder?
|
4 mg/day
|
|
|
MOA of cephalosporins?
|
prevents synthesis of bacterial cell wall
|
|
|
CEFZIL (cefprozil) is 2nd generation?
|
YES
|
|
|
Dose of CEFZIL (cefprozil) for secondary bacterial infection of acute bronchitis?
|
500 mg BID
|
|
|
What drug affects cefprozil (CEFZIL)?
|
probenicid results in a douubling of the cefprozil AUC
|
|
|
CEFTIN (cefuroxime) is 2nd gen?
|
YES
|
|
|
Inidication of CEFTIN (cefuroxime)?
|
pharyngitits/tonsillitis, acute bacterial otitis media, acute bacterial maxiallary sinusitis, acute bacterial exacerbation of COPD, uncomplicated skin & skin structure infection, uncomplicated UTI, uncomplicated gonorrhea, impetigo, early LYME dx-
is that all???!!! |
|
|
Cephalexin, (KEFLEX) indicated for genitourinary infection like acute prostatitis caused by E.coli, P, mirabellis, K. pneumo?
|
YES
|
|
|
Probenicid inhibits the excretion of cephalexin (KEFLEX)?
|
YES
|
|
|
CIPRO (ciprofloxacin) increases the concentration of theophylline by 33%?
|
YES
|
|
|
Dose of TEQUIN (gatifloxin)for acute bacterial exacerbation of chronic bronchitis?
|
400 mg/day x 7-10 days
|
|
|
Indication of PO solution or pulvules of vancomycin (LYPHOCIN, VANCOCIN)?
|
oral solution or pulvules for staphylococcal enterocolitis & antibiotic associated pseudomembranous colitis caused by C. difficile
|
|
|
Severe ADR of vancomycin (LYPHOCIN, VANCOCIN)?
|
nephrotox, ototox, BMS, hypersensitivity
|
|
|
Indication of CLEOCIN (clindamycin)?
|
treatment of serious infections caused by streptococci, pneumococci, & stapylococci (NOT INFLUENZA)
|
|
|
Severe ADR of CLEOCIN (clindamycin)?
|
pseudomembranous colitis (severe)
also hypersensitivity, jaundice, severe skin eruption |
|
|
What drugs does clindamycin (CLEOCIN) have an effect on?
|
neuromuscular blocking agents (enhanced NM block) & erythromycin (antagonistic effect on antibacterial activity)
|
|
|
Dose of Z-PACK (azithromycin)?
|
250 mg (6 tabs): 500mg on day 1, then 250 mg days 2-5
|
|
|
Common ADR of ZITHROMAX (azithromycin)?
|
N/D, ab pain, elevated LFTS
|
|
|
Dose of FLAGYL (metronidazole) for tmt of trichomoniasis?
|
2 g (2000 mg) single dose same as for bacterial vaginosis
|
|
|
Counsel pt about amoxicillin (AMOXIL)?
|
complete entire prescription, discard reconstituted suspension after 14 days, refrigeration is preferable but not required
|
|
|
MOA OF BACTRIM (SEPTRA, TMP-SMX)?
|
inhibit folate synthesis
|
|
|
Indication of SEPTRA (BACTRIM, TMP-SMX)?
|
UTI, acute otitis media, tmt or prophylaxis for pneumocystis carinii pneumonia (PCP), traveler's D by E. coli
|
|
|
common ADR for Bactrim (SEPTRA, TMP-SMX)?
|
N/V, anorexia, rash, urticaria, hyperkalemia, arthralgia, myalgia, hepatitis
|
|
|
Indication for nitrofurantoin (MACROBID, MACRODANTIN)?
|
UTI caused by E.coli, enterococci,
S. aureus, Klebsiella, and enterobacter |
|
|
CI of MACROBID (nitrofurantion)?
|
hypersensitivity rxn, estimated crcl <60 ml/min
|
|
|
Common ADR of amphotercin B (AMPHOCIN, FUNGIZONE)?
|
NEPHROTOX, ELECTROLYTE WASTING (ESP MG & K), ANEMIA, & INFUSION RXN (FEVER, CHILLS, N, FLUSHING, TACHYCARDIA, HYPOTENSION)
|
|
|
Dosage form of nystatin (MYCOSTATIN)?
|
PO suspension: 50, 150, 500 million units,
1, 2, 5 billion units (powder) 100,000 units/ml (mycostatin) 500,000 unit tablets |
|
|
Drugs increasing the concentration of intraconazole (SPORONAX)?
|
macrolide antibiotics (clarithromycin)
PIs: (indinavir, ritonavir) |
|
|
Absolute contraindication of ZIAGEN (abacavir)?
|
hypersensitivity rxn
|
|
|
Dose of ZERIT (stavudine) for HIV infection?
|
>= 60 kg 40 mg BID
|
|
|
Severe ADR of NORVIR (ritonavir)?
|
HYPERGLYCEMIA (borderline diabetic), hypersensivity, pancreatitis, redistribution/accumulation of body fat, increase total triglyceride or cholesterol
|
|
|
Ritonavir (NORVIR) decrease level of theophylline by 43%?
|
YES
|
|
|
Ritonavir increases the level of rifabutin (MYCOBUTIN)?
|
YES
|
|
|
Rfampin decreases ritonavir (NORVIR) AUC by 35%
|
Yes
|
|
|
Indication of CARDURA (doxazosin)?
|
treatment of HTN, BPH
|
|
|
Indication of HYTRIN (terazosin)?
|
HTN, BPH
|
|
|
Indication of FLOMAX (tamsulosin)?
|
BPH
|
|
|
Dosage form of tamsulosin (FLOMAX)?
|
0.4 mg tablet
0.4-0.8 mg/day |
|
|
What drug class are doxazosin (CARDURA) & terazosin (HYTRIN)?
|
ALPHA-1 BLOCKER
|
|
|
preganacy cat of clonidine (CATAPRES)?
|
C
|
|
|
Initial & Max dose of benazepril (LOTENSIN)?
|
INITIAL DOSE 10 MG/DAY
MAX DOSE 40 MG/DAY |
|
|
WHAT drug does benazepril (LOTENSIN) have an effect on?
|
digoxin, Li, K sparring diuretics, K supplements (all aceis effect these drugs)
|
|
|
Initial dose of captopril (CAPOTEN) for HTN?
|
25 mg BID-TID
|
|
|
DF of enalapril (VASOTEC)?
|
TABLETS & INJECTIONS
|
|
|
Indication of enalapril (VASOTEC)?
|
HTN, HF, LVD
|
|
|
Common ADR of quinapril (ACCUPRIL)?
|
hypotension, cough, hyperkalemia
ALL ACEIS HAVE THESE ADRS!! |
|
|
What is the therapeutic blood level of theophylline?
|
8-15 mcg/ml
|
|
|
Ipratropium (ATROVENT) worsens what disease states?
|
NARROW ANGLE GLAUCOMA
|
|
|
Dose of certirizine (ZYRTEC)?
|
2-6 YO 2.5 mg QD
>6 10 mg QD |
|
|
SE of certirizine (ZYRTEC)?
|
drowsiness, somnolence, dizziness, HA
|
|
|
Dose of TEQUIN ( gatifloxacin) for acute bacterial exacerbation of chronic bronchitis?
|
400 mg/day
|
|
|
Indication of oral solution or pulvules of vancomycin (LYPHOCIN)?
|
staphylococcal enterocolitis & pseudomembranous colitis caused by C. difficile
|
|
|
Severe ADR of vancomycin (LYPHOCIN, VANCOCIN)?
|
nephrotoxicity, ototoxicity, BMS, hypersensitivty
|
|
|
Indication of CLEOCIN (clindamycin)?`
|
Treatment of serious infections caused by streptococci, pneumococci, & stapylococci (NOT INFLUENZA)
|
|
|
severe ADR of CLEOCIN (clindamycin)?
|
pseudomebranous colitis (also severe skin eruptions, hypersensitivity & jaundice)
|
|
|
What drugs does clindamycin (CLEOCIN) have an effect on?
|
NM blocking agents & erythromycin
|
|
|
Dose of Z-PACK (azithromycin)?
|
250 mg (6 tabs): 500 mg on day 1, then 250 mg days 2-5
|
|
|
Common ADR OF ZITHROMAX (azithromycin)?
|
N,D, ab pain, rash, elevated LFTs
|
|
|
dose of FLAGYL (metronidazole) for tmt of trichomoniasis?
|
2g single dose (same tmt as bacterial vaginosis)
|
|
|
Counsel pt about pcn (AMOXIL)?
|
complete entire prescription, discard reconstituted suspension after 14 days, refrigeration is preferable but not required
|
|
|
Concentration of CILOXAN (ciprofloxacin) opthalmic?
|
0.3%
|
|
|
dose of DETROL (tolteradine)?
|
1-2 mg BID IR
4 mg daily ER |
|
|
max dose of pravastatin (LESCOL)?
|
80 MG/DAY
ALL HMG COA REDUCTASE INHIBITORS MAX 80 MG/DAY! |
|
|
Indication of TPA, alteplase (ACTIVASE)?
|
acute MI, ischemic stroke, PE
|
|
|
Dose of enoxaparin (LOVENOX) for hip replacement prophylaxis?
|
30 mg Q 12 SQ (with initial dose given 12-24 hrs post-op x 7-10 days)
or 40 mg SQ daily for high risk surgery |
|
|
which PO contraceptive is used to treat moderate acne vulgaris?
|
Ortho-Tri cyclen
|
|
|
Strength of PREMARIN (conjugated estrogens)?
|
0.3. 0.625, 0.9, 1.25. 2.5 mg tablets
|
|
|
ESTRACE DFs (estradiol)?
|
tablets
|
|
|
RISPERDAL (risperidone) dose adjustment?
|
in 1 week
|
|
|
abacavir (ZIAGEN) mechanism?
|
NRTI-indirect, competitive inhibition of reverse transcriptase-
guanosine analogue which is phophorylated to carbovir which interferes with HIV viral RNA |
|
|
INDERAL (propranolol) has a drug interaction with?
|
digoxin, VERAPAMIL, & diltiazem-enhanced decrease in AV node condution
|
|
|
PLENDIL (felodipine) max dose?
|
10 mg/d
|
|
|
NORVASC (amlodipine) max dose for angina?
|
10 mg/d (same as for HTN)
|
|
|
NORVASC (amlodipine) MOA?
|
directly decreases heart rate by inhibiting movement of Ca ions across the cell membrane
|
|
|
Triamcinolone (AZMACORT) directions for use?
|
2 puffs 3-4 times a day of 4 puffs twice daily
|
|
|
Most common ADRS of ACEi?
|
hypotension (esp 1st dose), cough, hyperkalemia
|
|
|
Most common ADR of BBs?
|
decrease sexual actvity, fatigue, (also hypotension, bradycardia, dizziness, lethargy)
|
|
|
Indication for PROVERA (medroxyprogesterone)?
|
secondary amenorrhea
|
|
|
Indication of NOLVADEX (tamoxifen)?
|
metastatic breast cancer
|
|
|
Dose of AVANDIA (rosiglitazone)?
|
4 mg/d
|
|
|
Class of glimepiride (AMARYL)?
|
sulfonylurea
|
|
|
Dose of clindamycin (CLEOCIN)?
|
150-450 mg PO QD or 600-2700 mg/day IV or IM
|
|
|
ZITHROMAX (azithromycin) caution?
|
pts w/ hepatic dysfunction
|
|
|
How does rifampin affect fluconazole (DIFLUCAN)?
|
rifampin increases the metabolism of fluconazle (decreasing the AUC)
|
|
|
AUGMENTIN (amoxicillin/clavulanate) treats what?
|
H. influenza, S.Aureus, M. catarrhalis
|
|
|
CI of cholestyramine (QUESTRAN)?
|
complete biliary obstruction
|
|
|
What spectrum does cephalexin (KEFLEX) cover?
|
streptococcus, staph, klebsiella, e.coli, p.mirabilis
|
|
|
CI for statins?
|
pregnancy, active liver dx, lactation
|
|
|
Which of the following is true about celebrex-avoid ASA, avoid NSAIDS, take without regard to meals, all of the above?
|
avoid ASA-combined increases risk of GI bleed
|
|
|
ingredients of VICODIN?
|
hydrocodone & APAPP
|
|
|
CI of ULTRAM (tramadol)?
|
use within 14 days of MAOI therapy, hypersensitivity to ultram of opioids
|
|
|
What is the infusion time for APAP?
|
over 4-6 hours
|
|
|
Generic name of SUSTIVA?
|
efavirenz
|
|
|
Generic of CEFTITIN?
|
cefuroxime
|
|
|
Brand name of bezapril?
|
LOTENSIN
|
|
|
Brand name of moxifloxacin?
|
AVELOX
|
|
|
DF of heparin?
|
IV & SQ
|
|
|
(T/F) PO dose of levofloxacin (LEVAQUIN) is increased by 20% of the IV dose to adjust the AUC by 80%?
|
T
|
|
|
Brand name of oxifloxacin?
|
FLOXIN & OCUFLUX
|
|
|
Brand name of nitrofurantoin?
|
MACROBID/MACRODANTIN/FURADANTIN
|
|
|
Spectrum of vancomycin (LYPHOCIN/VANCOCIN)?
|
gram +
|
|
|
Drug class of cisplatin (PLATINOL)?
|
platinum compound
|
|
|
Brand name of cyclophosphamide?
|
CYTOTOXAN
|
|
|
What would you not say to when counseling a pt about CYTOXAN (cyclophosphamide)?
|
Do NOT drink a lot of fluids (BECAUSE PTS ON CYTOXAN SHOULD DRINK LOTS OF FLUIDS)
|
|
|
Max dose of IMITREX (sumatriptan)?
|
PO 200 mg daily
SQ 12 mg/d |
|
|
What is caused by long term use of estrogens?
|
uterine cancer
|
|
|
generic name of ZYLOPRIM?
|
allopurinol
|
|
|
What is indicated for the treatment of BPH?
|
FLOMAX (tamsulosin)
HYTRIN (terazosin) CARDURA (doxazosin) PROSCAR (finasteride) AVODART (dutasteride) |
|
|
Which steroid is indicated to treat eczema?
|
mometasone (ELOCON)
|
|
|
COZAAR (losartan) starting dose?
|
50 mg/day
|
|
|
Generic name of PLENDIL?
|
felodipine
|
|
|
SE of PLENDIL (felodipine)?
|
Ha, flushing, edema, hypotension, dizziness/lightheadedness, asthenia, flushing
|
|
|
Toxicity of doxorubicin (ADRIAMYCIN)?
|
Cardiotoxicity
|
|
|
Max lifetime dose of doxorubicin (ADRIAMYCIN)?
|
550 mg/m2
|
|
|
Which SE is not seen in tamoxifen (NOLVADEX) therapy?
|
osteoporosis
SEs include hot flashes, vaginal disharge/bleeding, menstrual irreg rarely blood clots, hair loss bone pain |
|
|
What is not an FDA indication of propranolol (INDERAL)?
|
asthma (its an absolute CI)
inidcations include HTN, angina, MI, migraine prophylaxis, ventricular arrythmias, adjunctive management of pheochromocytom, essential tremors, hypertophic subaortic stenosis |
|
|
Brand name of propranolol?
|
INDERAL
|
|
|
Initial & max dose of propranolol for HTN?
|
initial 40 mg BID (80 mg QD long-acting tablets)
max 640 mg daily |
|
|
ses of propranolol?
|
hypotension, lethargy, dizziness, bradycardia, decreased sexual ability
rare/sever/imp hallucinations, heptatotox, leukpenia |
|
|
CI of propranolol?
|
decompensated heart failure, asthma, cardiogenic shock, hear block, sinus bradycardia
|
|
|
Mechanism of action of diltiazem (CARDIZEM, DILACOR, TIAZAC, CARTIA)?
|
inhibit movement of ca ions across cell membrane which relaxes coronay vascular smooth muscle & causes coronary vasodilation DECREASED HEART RATE
|
|
|
How do you counsel a pt on aledronate (FOSAMAX)?
|
Take tablet with 6-8 oz of plain water 1st thing in the morning. (Don't take with OJ or coffee)
|
|
|
Brand name of mecaptopurine?
|
PURINETHOL
|
|
|
What is an adjuntive treatment for H. pylori infection?
|
any PPI (except PROTONIX/pantoprazole)
NEXIUM/esomeprazole PREVACID/lansoprazole PRILOSEC/omeprazole ACIPHEX/rabeprazole |
|
|
Common ADRs of proton pump inhibitors?
|
HA, D, AB PAIN, N
|
|
|
CI of raloxifene (EVISTA)?
|
pregnancy, active of HX of venothromboembolic events, premenopausal women
|
|
|
Dose of raloxifene (evista) to prevent/treat postmenopausal osteoporosis?
|
60 mg daily
|
|
|
ADRs of raloxifene/EVISTA?
|
hot flashes, N
rare/severe: muscle aches, vaginal bleeding ab pain |
|
|
PC of raloxifene/EVISTA?
|
X
|
|
|
drug class of raloxifene/EVISTA?
|
SERM (selective estrogen receptor modulator that inhibits bone resorption and reduces biochemical markers of bone turnover)
|
|
|
Generic name of LOTEL?
|
amlodipine/benzapril
|
|
|
LOTREL (amlodipine/benzapril) pregnancy risk factor?
|
C in 2nd trim, D in 3rd
|
|
|
Celebrex has?
|
sulfur
|
|
|
drug inducers?
|
carbamazepine, phenytoin
|
|
|
What is the maintenance dose of ACIPHEX (rabeprazole)?
|
20 mg/day
|
|
|
pt counseling for NSAIDS?
|
take with food or milk
|
|
|
SE of warfarin (COUMADIN)?
|
alopecia, D, N, bleeding, fever
|
|
|
initial dose of warfarin?
|
5 mg
|
|
|
DFs of warfarin?
|
1, 2, 2.5, 3, 4, 5, 6, 7.5, 10mg
tablets 2mg/ml powder for inj |
|
|
starting & max dose of sertraline (ZOLOFT)?
|
50 mg/day initial
200 mg/day max |
|
|
indications of sertraline (ZOLOFT)?
|
DEPRESSION, OCD, PANIC DISORDER, PTSD
|
|
|
ADRS OF ZOLOFT?
|
GI, sexual dysfuntion, sedation or sleeplessness, WD syndromes
hyponatremia, SIADH (same for all SSRIs) |
|
|
Heparin loading dose for treatment of thromboembolism?
|
80 units/kg IV
|
|
|
LOVENOX (enoxaparin) initial dose?
|
30 mg q12 SC
|
|
|
antipsychotics like quetiapine (SEROQUEL) usually cause what SE?
|
tardive dyskinesia
|
|
|
Indication of buproprion (WELLBUTRIN)?
|
depression & smoking cessation
|
|
|
Allopurinol (ZYLOPRIM) dosing?
|
200-300 mg/d comes in 100 & 300 mg tab
|
|
|
Indication & dosing for metronidazole (FLAGYL)?
|
trichomoniasis 2 g po single dose
bacterial vaginosis 2 g po single dose or 500 mg BID for 7-14 days |
|
|
If a patient does not respond to the 1st dose of sumatriptan (IMITREX) how long must they wait before the 2nd dose?
|
PO or nasal spray more at least 2 hours
inj at least 1 hr |
|
|
Dose of ACIPHEX (rabeprazole)?
|
20 mg/d
|
|
|
Indication of raloxifene (EVISTA)?
|
osteoporosis 60 mg/d
|
|
|
Indication for trazodone (DESYREL)?
|
depression 300-500 mg/d
|
|
|
Dose CARDURA (doxazosin) treat class IV heart failure or HTN?
|
HTN
|
|
|
Indication for ondansetron (ZOFRAN)?
|
prevention of N & V (in chemo pts)
|
|
|
Dosage of REMERON (mirtazepine)?
|
depression 15-45 mg/d
|
|
|
Initial dose of nabumetone (RELAFEN)?
|
1000 mg a day in divided doses (500 mg BID)
|
|
|
SE of metformin (GLUCOPHAGE)?
|
rash, N,V,D,BMS/THROMBOCYTOPENIA (MEGABLASTIC ANEMIA)
|
|
|
When mixing insulin, should you draw regular insulin first or draw NPH first?
|
regular
|
|
|
What decreases hepatic production and absorption of glucose in GI? insulin, metformin, gyburide, glipizide
|
METFORMN
|
|
|
Dosage of ARICEPT (donepezil)?
|
Alzheimers: 5 mg PO QHS (5 & 10 mg tablets)
|
|
|
Indication for SOMA (carisoprodol)?
|
muscle relaxant 350 mg TID-QID
|
|
|
Duragesic (fentanyl) drug interactions?
|
sedative hypnotics, etoh, muscle relaxants, analgesics
|
|
|
Dosage of gatifloxacin (TEQUIN)?
|
400 mg capsules QD for 7-14 days. comes in 200 & 400 mg capsules
|
|
|
ZITHROMAX (azithromycin) drug interactions?
|
digoxin, cyclosporine, phenytoin
|
|
|
side effect of MEVACOR (lovastatin)?
|
GI upset (N,V) myalgias (muscle cramps) rarely-hepatotoxicity, myopathy, rhabdo
|
|
|
Dosage of PRILOSEC (omeprazole)?
|
GERD, duodenal ulcer 20 mg/day
forms 10, 20, 40 mg cap |
|
|
Warfarin's dosage range?
|
1, 2, 2.5, 3, 4, 5, 6, 7,5, 10 mg tablets
2mg/ml pow for inj |
|
|
initial dose of warfarin?
|
5 mg PO QD (maintenance 1-10 mg daily titrate based on INR)
|
|
|
CELEBREX (celecoxib) starting dose?
|
OA 200 MG DAILY
RA 100-200 MG BID |
|
|
Metformin's SE's?
|
lactic acidosis which can be fatal-also D, HA, flatulence, metallic taste, V, weight loss, dyspepsia, megaloblastic anemia
|
|
|
Forms of ZOLOFT (sertraline)?
|
25, 50, 100 mg tablets
(also PO concentrate 20 mg/ml) |
|
|
SE of warfarin?
|
alopecia, NVD, bleeding, rash, skin necrosis, purple toe syndrome
|
|
|
dosage form of IMDUR (isosorbide mononitrate)?
|
IMDUR is extended release & comes in 30, 60, 120 mg tablet
|
|
|
DF of MONOKET/ISMO (isorbide mononitrate IR)?
|
10, 20 mg tabs
|
|
|
indication for ZOCOR (simvastatin)?
|
hypercholesterolemia
|
|
|
LIPITOR (atorvastatin) primarily decreases which of the following-LDL, HDL, triglycerides, cholesterol?
|
LDL
|
|
|
DFS OF ALLEGRA (fexofenadine)?
|
30. 60, 180(ER), tab
60 mg cap |
|
|
dosing of ALLEGRA (fexofenadine)?
|
6-11 30 mg BID
>12 60 mg BID or 180 x 1 |
|
|
Starting dose of NAPROSYN (ANAPROX, ALEVE-OTC, narproxen?
|
250-500 mg BID
|
|
|
Metoprolol (LOPRESSOR, TOPROL XL) interacts with what?
|
verapamil ( also dig & dilt) enhanced decrease in AV node conduction
|
|
|
How long before exercising do you use salmeterol (SEREVENT)?
|
30 MIN PRIOR TO EXERCISE
|
|
|
DRUG class of salmeterol/serevent?
|
beta-2 agonist inhaled
|
|
|
ADRs of salmeterol/servent?
|
palpitations, tachycardia, tremor, HA, CNS stimulation
rare: hypokalemia, HTN |
|
|
Dosage for BIAXIN (clarithromycin) for pharyngitis & sinusitis?
|
Pharyngitis 250 mg BID x 10
sinusitis 500 mg BID x 14 |
|
|
Risperdal/risperidone MOA?
|
atypical antipsychotic that inhibits dopamine & antagonizes serotonin
|
|
|
ADRs of atypical antipsychotics like riperdal/risperidone & zyprexa/olanzapine?
|
sedation, HA, anticholinergic effects esp w/zyprexa/olanzapine, orthostasis esp w/risperdal, NMS, hyperglycemia, drug-induced DM, EPS, hepatotox
|
|
|
paroxetine (PAXIL) indication?
|
social anxiety disorder (and depression, OCD, panic disorder, , GAD, PTSD)
|
|
|
olanzapine (ZYPREXA) INDICATION?
|
antipsychotic indicated for schizophrenia & acute mania
|
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risperidone (riserdal) indication?
|
management of psychotic disorders
|
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venlafaxine (EFFEXOR) adult indication?
|
depression, GAD start 37.5 mg BID c food for depression
37.5 BID or 75 mg QD c food for GAD |
|
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Wellbutrin (BUPROPION) starting dose?
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depression 100 mg BID
smoking cessation 150 mg/d x 3 d |
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Indication and dosage of Pravachol/pravastatin?
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hypercholesterolemia 10-20 mg daily
|
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Mupirocin (BACTROBAN) starting dose?
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impetigo: apply OINTMENT TID FOR 3-5 DAYS
infected wounds: apply CREAM TID X 10 DAYS |
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lovastatin/MEVACOR DF, initial dose and SE?
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10, 20, 40 mg tab
10, 20, 40, 60 mg er tab 10-20 mg PO QD c PM meal GI, myalgias, hepatotox, myopathy, rhabdo |
|
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Indication for FLOMAX (tamsulosin) and dosing?
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BPH 0.4 mg daily 30 min after meal
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|
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initial dose of viagra/sildenafil?
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50 mg 30 min-4 hr b4 sexual activity
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adrs of VIAGRA/sildenafil?
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HA, FLUSHING, DYSPEPSIA, ABNORMAL VISION (BLUE/GREEN), NASAL CONGESTION, HYPOTENSION, PRIAPISM
|
|
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MOA OF VIAGRA/SILDENAFIL?
|
PDE5 INHIBITOR LEADING TO INCREASED LEVELS OF cGMP ENHANCING EFFECTS OF NO LEADING TO SMOOTH MUSCLE RELAXATION IN CORPUS CAVERNOSUM
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CI OF VIAGRA/SILDENAFIL?
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concomitant nitrates
|
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starting dose of DETROL (tolteradine)?
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1-2 mg PO BID for overactive bladder
|
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SE of rifampin
|
NV, rash, cramps
also: fever, drowsiness, elevated LFTs, hypersensitivity, hyperbilirubinemia, thrombocytopenia |
|
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MOA of venlafaxine (EFFEXOR)?
|
inhibitor of neural serotonin & NE reuptake
|
|
|
concentration of olofloxacin (FLOXIN) eye drops?
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0.3%
|
|
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Stavudine (ZERIT) dose?
|
>= 60 kg 40 mg BID
< 60 kg 30 mg BID |
|
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Ritonavir (NORVIR) MOA?
|
inhibits HIV protease
|
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Levofloxacin (LEVAQUIN) MOA?
|
inhbits DNA gyrase
|
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NSAIDs interact with what?
|
methotrexate
also Li, CSA, TAC, ACEI, thiazides, lasix |
|
|
indication of diltiazem (CARDIZEM, DILACOR, TIAZAC, CARTIA)?
|
angina, HTN decrease heart rate
|
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IS fluoxetine (PROZAC) used and approved for depression and OCD?
|
Y
|
|
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Dopamine trade name?
|
INTROPIN
|
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VIAGRA SHOULD NOT BE TAKEN WITH WHAT?
|
NITRATES-FOOL!
|
|
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HOW DO YOU TAKE VIAGRA?
|
1 HR PRIOR TO SEXUAL HEALING!
|
|
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TRADE NAME OF PRAVASTATIN?
|
PRAVACHOL
|
|
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TRADE NAME OF LOSARTAN?
|
COZAAR
|
|
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WHICH OF THE FOLLOWING IS TRUE ABOUT CLONAZEPAM? ITS A BENZO, BINDS TO GABA, TRADE NAME IS KLONOPIN
|
ALL ARE TRUE!!!
|
|
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What flavor does AUGMENTIN COME IN?
|
orange (250 mg)
banana (125 mg) |
|
|
which sulfonylurea is in glucovance?
|
glyburide (diabeta, micronase)
|
|
|
fluconazole is indicated to kill what organism?
|
candida
|
|
|
itraconazole (SPORANOX) pt counseling?
|
Don't take with antacids
|
|
|
What should a pt do when missing a dose of OC?
|
take ASAP or take 2 pills the next day
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|
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CYCRIN contains what?
|
medroxyprogesterone
|
|
|
Proper counseling for eye drops?
|
wash hands thoroughly
|
|
|
brand name for lantanoprost?
|
XALANTAN 0.005%
|
|
|
SE for ondansetron (ZOFRAN)?
|
malaise, fatigue, HA, drowsiness, D, elevated LFTs, constipation, pruritus/rash
|
|
|
Phnergan (promethazine) may cause?
|
HTN, tachycardia, hyperglycemia
|
|
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What dose range for CEFZIL (cefprozil) for secondary bacterial infection?
|
500 mg BID x 10 days
|
|
|
max dose of motrin/advil/midol/nuprin/haltran/excedrin IB/ ibuprofen?
|
3.2 g/day
|
|
|
What is the reason why we don't give children doxycycline/VIBRAMYCIN?
|
b/c their teeth can be permanently discolored
|
|
|
What does CLIMARA contain?
|
estradiol
|
|
|
Provera (medroxyprogesterone) is used in women with (indications)?
|
secondary amenorrhea,
abnormal uterine bleeding due to hormonal imbalance, decrease of endometrial hyperplasia in post-menopausal women |
|
|
what ingredient is in oral contraceptives?
|
norgestrel, norethindrone, desogestrel
|
|
|
Percocet is not class III b/c?
|
its class II contains oxycodone
|
|
|
Trade name of glipizide?
|
GLUCOTROL
|
|
|
WHAT (antidiabetic) agent comes is 2, 4, 8 mg?
|
AVANDIA (rosiglitazone)
|
|
|
dose for metformin (glucophage XR)SR?
|
500 mg ER c am meal
|
|
|
What drugs interact with Climara (estradiol)?
|
rifampin, hydrocortisone
|
|
|
PREMARIN IS?
|
conjugated estrogen
|
|
|
indication for VASOTEC (enalapril)?
|
HTN & CHF
|
|
|
Duragesic/fetanyl maintenace dose?
|
25-400 mcg/hr, change q 72 hours
|
|
|
Vicodin contains what?
|
hydrocodone & APAP
|
|
|
Which of the following does not contain APAP?
LORCET, VICOPROFEN, PERCOCET, PERCODAN? |
vicoprofen (hydrocodone & ibuprofen) & percodan (oxycodone and aspirin)
|
|
|
Nabumetone is what class of drugs?
|
NSAIDS
|
|
|
metformin (GLUCOPHAGE) contraindicated in what?
|
CHF, metabloic acidosis, renal dx (men SCR >1.5, women scr >1.4)
|
|
|
AE of metformin (GLUCOPHAGE)?
|
lactic acidosis, megaloblastic anemia (also weight loss, anorexia, dyspepsia, NV, flatulence, metallic taste)
|
|
|
When is insulin 0.5-1 UNIT/kg administered?
|
30 minutes to 1 hour before meals
|
|
|
NOVOLIN 70/30 is?
|
70% NPH
30% REGULAR |
|
|
pioglitazone (ACTOS) interacts with?
|
ketoconazole and etoh
|
|
|
Pioglitazone ACTOS monitoring?
|
liver enzymes (transaminases)
|
|
|
Which is not a 5th generation cephalosporin?
|
there are no 5th generation cephalosporins
|
|
|
Vancomycin (LYPHOCIN/VANCOCIN)?
|
staph & enterocolitis caused by C. difficile
|
|
|
Clindamycin (CLEOCIN) interacts with what other drugs?
|
neuromuscular blocking agents-enhanced NM block
|
|
|
erythromycin (ERY-TAB, ERYPED, E-MYCIN, EES, ILOSONE) SE?
|
hepatotoxicity (estolate base) & ototoxicity high dose 250 mg QID
|
|
|
metronidazle (FLAGYL) indication?
|
trichomoniasis
|
|
|
B-lactam portion of augmentin is?
|
clavulanate
|
|
|
AE of BACTRIM (tmp-smx)?
|
TEN, hepatic necrosis, agranulocytosis, aplastic anemia and more commonly NV, anorexia, rash, urticaria, hyperkalemia, arthralgias, myalgias, hepatitis
|
|
|
SE of doxycycline (VIBRAMYCIN)?
|
disorder of teeth in children
|
|
|
minocycline (MINOCIN) should not be given concurrently with?
|
aluminum, Ca, Mg, Fe
|
|
|
MACROBID/MACRODANTIN/nitrofuranoin
covers which organism? |
KLEBSIELLA, E.COLI, S. AUREUS, ENTEROCOCCI
|
|
|
SUSTIVA (efavirenz) indicated to treat what?
|
hiv
|
|
|
Stavudine (ZERIT) dosing for >= 60 kg pts?
|
40 mg BID if less thatn 60 kg give 30 mg BID
|
|
|
Ritonavir/NORVIR interacts with what?
|
rifabutin, ketoconazole, clarithromycin
|
|
|
Cyclophosphamide (CYTOXAN) SES?
|
leukopenia, alopecia, mucositis, hemorrhagic cystitis
|
|
|
Dose of mercaptopurine (PURINETHOL)?
|
50 mg tablets (1.5-2.5 mg/kg/day)
|
|
|
mercaptopurine (6MP/PURINETHOL) is what drug class?
|
antimetabolite
|
|
|
Mercaptopurine is affected by?
|
allopurinol
|
|
|
cisplatin/PLATINOL is used to treat?
|
malignancies
|
|
|
Terazosin/HYTRIN is part of which class?
|
alpha-1 blocker
|
|
|
enalapril/VASOTEC is indicated to treat what?
|
HTN, CHF (2.5 mg/d for HF & 5 mg/day HTN initial max for both is 40 mg/d)
|
|
|
fosinopril/MONOPRIL initial dose for HTN?
|
10 mg/day
|
|
|
digoxin/LANOXIN/DIGITEK indicated for?
|
atrial fibrillation and CHF
|
|
|
atenolol/TENORMIN initial dose?
|
50 mg/day
|
|
|
AE of beta-blockers?
|
bradycardia (and hypotension, decreased libido, lethargy, dizziness)
|
|
|
Diltiazem available in?
|
tablets, capsules and inj
|
|
|
Imdur (ismo/monoket/isosorbide mononitrate) AE?
|
HA, flushing, rebound HTN, A fib
|
|
|
NITROQUICK (nitrostat/nitroglycerin) SL dose?
|
0.3-0.6 mg repeated at 5 min intervals
|
|
|
Triamterene?HCTZ (DIAZIDE/MAXIDE) inidcation
|
this combo is NOT indicated for initial therapy of edema of HTN EXCEPT in pts WITH HYPOKALEMIA
|
|
|
OC components?
|
levonorgestrel, ethinyl estradiol, norethindrone
|
|
|
Cycrin (medroxyprogesterone) indication?
|
secondary amenorrhea (also abnl uterine bleeding due to hormonal imbalance, reduction of endometrial hyperplasia...)
|
|
|
other names for Provera?
|
cycrin, depo-provera, medroxyprogesterone
|
|
|
Raloxifene/EVISTA is indicated for what?
|
prevention and treatment of postmenopausal osteoporosis
|
|
|
Prednisone (DELTASONE) available in what dosage forms?
|
1, 2.5, 5, 10, 20, 50 mg tablets and PO solution
|
|
|
levothyroid (LEVOXYL,levothyroxine) is indicated for?
|
hypothyroidism, myxedema coma
|
|
|
ZANTAC/ranitidine is indicated for?
|
GERD, erosive esophagitis, hypersecretory conditions
|
|
|
Cimetidine (tagamet) contraindications?
|
hypersensitivity to cimetidine
|
