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5 Cards in this Set
- Front
- Back
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Draw Glycolysis and GNG
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Glycolysis aside GNG
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Malonate is a competitive inhibitor of succinate in the succinate dehydrogenase reaction. Why can this be overcome by raising the oxaloacetate concentration.
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Assuming a sufficient supply of acetyl-CoA raiseing the oxaloacetate concentration has the effect of raiseing all the Citric Acid Cycle intermediates including succinate. Since malonate is a competitive inhibitor this can be overcome by increasing succinate
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Which of the following metabolites undergoes a net oxidation a-ketoglutarate, succinate, citrate, acetyl-CoA?
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Only acetyl-CoA under goes a net oxidation all the others are regenerated in one turn of the CAC.
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Why is the oxidation of succinate to fumarate only associated with the production of two (2) ATPs, while oxidation of malate to oxaloacetate produces three (3) ATP?
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The oxidation of succinate to fumarate catalyzed by succinate dehydrogenase involves the reduction of FAD to FADH2. Electrons from FADH2 enter the Electron Transport Chain at CoQ missing Complex I which pumps H+ as a result. Malate to Oxaloacetate catalyzed by malate dehydrogenase involves the reduction of NAD+ to NADH. The NADH electrons enter the ETC at complex I and therefore store more energy to make ATP by pumping H+.
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Why are people on a high protein diet instructed to drink lots of water?
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The nitrogen in from a high protein diet must be disposed of as urea. Since urea is excreted in relatively dilute amounts the diet must be accommpanied by sufficient water intake.
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