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13 Cards in this Set
- Front
- Back
What are the 3 major steps in thyroid hormone synthesis?
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1. trapping (transport of iodide into thyroid cells)
2. organification (iodination of tyrosine on thyroglobulin) 3. coupling (making MIT or DIT) |
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What are the drug interactions that cause hypothyroidism?
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amiodarone--> inh deiodinase
lithium--> inh TH synthesis phenytoin,carbamezapine, rifampin--> increase met of TH |
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Levothyroxine:
CU, AR, Interactions |
CU: hypothyroidism
AR: few side effects Interactions: increase catabolism of Vit K dependent factors (enhance the action of anticoagulants) |
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PTU/Methimazole
MOA, CU, AR |
MOA: inh TPO
AR: skin rash, lupus like rxn, agranulocytosis, hepatitis PTU is 1st choice in pregnant women and children with hypothyroidism |
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Perchlorate, Pertechnate, Thiocyanate
MOA, CU, AR |
MOA: block uptake of iodide
CU: hyperthyroidism AR: perchlorate--> fatal anaplastic anemia |
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Iodides
CU |
give when someone has radioactive iodide treatment done
|
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Propanolol
CU |
treat symptoms of hyperthyroidism
|
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I-131
CU |
irradiate the thyroid for extreme cases of hyperthyroidism
DO NOT GIVE TO PREGNANT WOMEN |
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What are the Sx of hyperthyroidism?
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warm, moist skin, heat intolerance, tremors, increased HR, SOB, increased BMR
|
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What are the Sx of hypothyroidism?
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pale, cool skin, decreased HR, hypoventilate, dec BMR, lethargic, periorbital puffiness, delayed DTRs
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What is the difference b/w I-123 uptake in thyroiditis and Graves?
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Thyroiditis--> no uptake
Graves--> diffuse uptake |
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What are the possible explanations for a patient who is hypothyroid for many years and suddenly has a inc in TSH?
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1. other meds (change in weight)
2. switching brands 3. calcium or vit D supplements 4. estrogen or BC |
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What is the significance of T3RU?
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high T3RU=hyperthyroidism
low T3Ru=hypothyroidism |