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4 Cards in this Set
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Thyroid/Antithyroid Drugs
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Hypothyroidism:
1) Thyroxine Hyperthyroidism 1) remove gland and replace T4 2) irradiate gland and replace T4 3) Inhibit Thyroperoxidase (Thyrourylenes) 4) Prevent peripheral deiodination of T4 (Sodium Iodide) 5) Interfere with SNS - facilitating action of T3 & T4 (b-blockers) |
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Thyroxine
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has 3x greater t1/2
slowly trickles T3 in adverse effects (hyperthyroid Sx) - sinus tachycardia, arrythmias, angina, restlessness, tremor |
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T3
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more rapidly effective
eliminated more rapidly immediate reversal of hypothyroid direct ligand needed for life threatening hypothyroidism in medical emergency |
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Thiourylenes
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Carbimazole and methimazole(not in Aus)
Propylthiouracil (which also inhibits deiodinases as well as peroxidases) very inconvienient |