Thomas First Aid Repro Pharm

Front 1

Prostate Cancer treatment (2)

Back 1

Leuprolide (continuous)
Flutamide (inhibits androgens binding receptor)

Front 2

Leuprolide mech, uses (2), toxicities

Back 2

GnRH analog

uses- infertility (pulsatile), prostate cancer (continuous), uterine fibroids

toxicities- N/V, antiandrogen

Front 3

use what to stimulate anabolism to promote recovery after burn/injury

Back 3

testosterone

Front 4

testosterone effect on:
epiphyseal plates
LDL
HDL

Back 4

can be converted in estrogen by body, can prematurely cloes epiphyseal plates with exogenous use

opposite of estrogen:
increase LDL, decrease HDL

Front 5

Flutamide mech

Back 5

competitive inhibitor of androgens at testosterone receptor

Front 6

ketokonazole mech for antiandrogen effects

Back 6

inhibits desmolase (produces androstenedione)

Front 7

spironolactone mech for antiandrogen effects

Back 7

inhibits steroid binding

Front 8

2 drugs that can be used for hirsutism in polycystic ovarian syndrome

Back 8

ketoconazole, spironolactone

Front 9

4 estrogen administration complications

2 contrindications

Back 9

complications- risk of clots, endometrial carcinoma, clear cell adenoarcinoma of vagina (DES in utero), postmenopausal bleeding

Her-2 positive cancer, history of DVTs

Front 10

Clomiphene mech, 2 uses

Back 10

partial estrogen agonist, prevents normal inhibition of LH and FSH at hypothalamus--> stimulates ovulation

used for infertility, PCOS

Front 11

2 hormone replacement indications?

additive?

Back 11

menopause
osteoporosis

add progesterone to avoid endometrial carcinoma

possible increased CV risk

Front 12

Anastrozole

Back 12

aromatase inhibitor (for postmenopasual breast cancer)

Front 13

Exemestane

Back 13

aromatase inhibitor (for post-menopausal breast cancer)

Front 14

2 uses for progestins

Back 14

endometrial cancer, abnormal uterine bleeding

Front 15

Mifepristone mech, use, toxicites (3)

Back 15

progesterone antagonist

for abortion (with misoprostol)

GI effects, abdominal pain, heavy bleeding

Front 16

OCPs decrease incidence of what 3 things?

Back 16

endometrial cancer, ovarian cancer, pelvic infections

Front 17

5 side effects of OCPs

Back 17

high TGs, depression, weight gain, HTN, nausea, hypercoagulable state

Front 18

3 contraindications for OCP

Back 18

smoker over 35
history of thromboembolism
estrogen-dependent tumor

Front 19

Dinoprostone mech, use

Back 19

PGE2 analog, induces labor

Front 20

Ritodrine mech, use

Back 20

B2 agonist

relax uterus to prevent premature contractions

"Ritodrine allow fetus to return to dreams"

Front 21

Terbutaline mech, use

Back 21

B2 agonist

relaxes uterus, tocolytic

Front 22

Tamulosin receptor action

Back 22

alpha 1(a,d) receptor specific (for prostate)

1b is for peripheral vasoconstriction

Front 23

Sildenafil/Vardenafil

4 toxicities

1 contraindication

Back 23

toxicities - headache, peptic distress, flushing, impaired blue-green color vision

"Hot and sweaty, but then Headache, Heartburn, Hypotension"

DON'T take with Nitrates- severe hypotension