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22 Cards in this Set
- Front
- Back
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Sickle cell trait - heterozygous
HbAs (more info) |
- FBE parameters will be normal
- Blood film will see normal + target cells - Positive sickling test - Molecular studies |
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HbSS - homozygous (more info)
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- anisocytosis
- poikilocytosis - polychromasia - sickle cells - nucleated RBC - Howell Jolie bodies, pappenheimer bodies - leucocytosis - HbS and HbF |
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HbC
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mild haemolysis
mild anaemia common in west africa increase in rigidity of RBS lower MCV normal or high MCHC |
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HbC
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target cells
microspherocytes possible migrates with HbA2 |
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What is the appearance of electrophoresis IFE on haemoglobinopathies
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**
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How is beta thalassaemia diagnosed>
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high or normal red cell counts
Normal or borderline Hb and Hct/PCV low MCV low MCH normal MCHC |
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What are the test results of beta thalassaemia
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iron studies are normal
HbEPP and High Performance Liquid Chromotography will show high levels of HbA and HbF HbH inclusion test is negative Should see high number of reticulocytes Family studies and molecular studies. |
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What is the Hb electrophoresis in Beta thalassaemia minor
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High A2 instead of A1,
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What is the electrophoresis panel for beta thal major
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What is the most common alpha thal?
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a-/aa (one gene deletion)
low top borderline Hb low to bordeline MCV, MCH, MCHC Normal or high RCC less severe than beta thal hypochromic/microcytic blood film |
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Describe HBH disease
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Moderate chronic haemolytic anaemia
Hb = 60 ‐ 100 g/L low MCV, MCH, MCHC ?nRBC reticulocytosis basophilic stippling uncommon |
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Describe film of HbH
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Describe the EPP of H barts
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Describe the diagnosis of alpha thalassaemia
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Describe the treatment and management of thalassaemias
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List 5 treatments of thalassaemia
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splenectomy
transfusion chelation therapy bone marrow transplant gene therapy |
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What are the iron studies results for IDA
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What are the iron studies results for thalassemia
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What are the iron studies results for Sideroblastic anaemia
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What are the iron studies results for ACD
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What are the iron studies results for lead poisoning
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Diagnose
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HbH
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