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5 Cards in this Set
- Front
- Back
TETRACYCLINES
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-Broad spectrum
-Obtained by fermentation with Streptomyces or by chemical transformations of natural products -Made of 4 annellated 6-member rings |
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MEDICAL USE: 9 Compounds
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TETRACYCLINE
CHLORTETRACYCLINE METHACYCLINE ROLITETRACYCLINE DEMECLOCYCLINE DOXYCYCLINE OXYTETRACYCLINE MECLOCYCLINE MINOCYCLINE |
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AMPHOTERIC
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-Salts will form with either acids or bases
-In neutral solution, they exist mainly as zwitterions |
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Salts used?
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1)KOH or NaOH- for salts of the acidic enol at C1,2,3. They are very soluble but unstable.
2)HCl- for oral use. Encapsulated bc bitter taste *Salt solutions must be stabilized with excess acid to prevent crystallization* |
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DRUG NAME=
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TETRACYCLINE
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