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22 Cards in this Set
- Front
- Back
ACEI |
renal damage |
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alkylating agents |
lack of digits multiple anomalies |
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aminoglycosides |
ototoxicity, vestibulotoxicity |
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antiepileptics |
neural tube defects, cardiac defects, cleft palate, skeletal abnormalitiets (phalanx/nail hypoplasia, facial dysmorphism) |
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diethylstilbestrol |
vaginal clear cell adenocarcinoma, congenital mullerian abnormalities |
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folate antagonists: trimethoprim, methotrexate, antiepileptics |
neural tube defects |
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isotretinoin |
multiple severe birth defects, pts must be on contraception to take this medication. |
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lithium |
ebstein anomaly (apical displacement of the tricuspid valve causing RHF) |
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methimazole |
aplasia cutis congentia |
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tetracyclines |
discolored teeth, inhibited bone growth |
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thalidomide |
limb defects (phocomelia, micromelia- flipper limbs) |
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warfarin |
bone deformities, fetal hemorrhage, abortion, ophthalmologic abnormalities. "Keep babbies heppy with heparin." |
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Fetal Alcohol Syndrome |
Cardiac (PDA, septal defects, tetralogy of fallot), microcephaly, facial abnormalities (smooth philtrum, thin vermillion border, small palpebral fissures), limb dislocation, developmental delays, intellectual disabilities. Severe: heart-lung fistulas and holoprosencephaly. All from cell migration failures. |
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Cocaine |
low birth weight, preterm birth, IUGR, placental abruption |
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Smoking |
Nicotine -> vasodilation, CO -> impaired O2 delivery. Low birth weight (#1 cause in developing countries), preterm labor, placental problems, IUGR, SIDS |
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iodine deficiency |
hypothyroidism (cretinism): pot-bellied, pale, puffy face, protruding umbilicus, protuberant tongue, short statue, poor brain development |
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maternal diabetes |
Macrosomia, hypoglycemia at birth, caudal regression syndrome (anal atresia to sirenomelia), cardiac (hypertrophic cardiomyopathy, transposition of the great vessels), neural tube defects |
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Methylmercury |
neurotoxicity. From seafood like swordfish, shark, tilefish, king mackerel. |
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Vitamin A excess |
high risk spontaneous abortions and birth defects (cleft palate, cardiac). |
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XR |
microcephaly, intellectual disability |
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Timing of teratogen exposure during gestation |
Most susceptible 3rd-8th weeks. <3wks all or none effect >8wks growth and function altered |
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chloramphenicol |
gray baby syndrome |