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12 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Clinical Manifestations |
Initial symptoms: low grade temp, weight loss, cough, fatigue, night sweats Cough (nonproductive/productive) - hemoptysis may occur Dyspnea and orthopnea |
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Isoniazid |
MOA: penetrates body cells and mycobacterium = inhibits formation of bacterial cell walls Inhibits growth of dormant organisms in macrophages and TB lesions |
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Isoniazid |
AE: damage to liver |
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Isoniazid |
BBW: severe and sometimes fatal hepatitis may occur within first 3 months or throughout therapy |
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Isoniazid |
Always given in combo with other anti-TB drugs for active TB |
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Isoniazid |
Risk of isoniazid-induced hepatitis worsens if patient consumes alcohol daily
Liver function tests MUST be done |
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Rifampin |
MOA w/ INH: eliminates TB bacilli from sputum produces clinical improvement the fastest (unless bacteria is resistant) |
Rifamycins |
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Rifampin |
HEPATOTOXICITY |
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Rifampin |
Use: latent TB or in combo for active TB |
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Rifampin |
Patient teaching: follow regimen exactly, take on empty stomach, avoid alcohol, take liver function tests, decrease effectiveness of BCP, and patient will feel better in 2-3 weeks for active TB |
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Rifampin |
Bactericidal for treatment of intracellular and extra cellular TB organisms |
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Rifampin |
Drug causes harmless red-orange discoloration in urine, sweat, tears, etc. |
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