Tag, Phospholipid, Cholesterol, And Steroid Synthesis

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Where does the branch point exist for TAG and phospholipids in the metabolic pathway from G3P?

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phosphatidic acid

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There is another pathway for phospholipids besides coming from phosphatidic acid, what is it?

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Where does the phosphate come from when a phospholipid is formed from a diacylgylcerol and an alcohol?

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CTP

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Synthesis of cholesterol require a __#__ stage process.

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4

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The production of cholesterol starts with 3 __________ molecules.

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The production of cholesterol starts with 3 acetate molecules.

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The production of cholesterol starts with ___ acetate molecules.

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The production of cholesterol starts with 3 acetate molecules.

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Formation of ____________ from 3 Acetyl-CoA begins similarly to ketone body synthesis.

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Formation of Mevalonate from 3 Acetyl-CoA begins similarly to ketone body synthesis.

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Formation of Mevalonate from _________________ begins similarly to ketone body synthesis.

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Formation of Mevalonate from 3 Acetyl-CoA begins similarly to ketone body synthesis.

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Formation of Mevalonate from 3 Acetyl-CoA begins similarly to _________ body synthesis.

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Formation of Mevalonate from 3 Acetyl-CoA begins similarly to ketone body synthesis.

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Formation of on activated _________ unit requires the input of 3 ATP.

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Formation of on activated isoprene unit requires the input of 3 ATP.

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Formation of on activated isoprene unit requires the input of ___________.

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Formation of on activated isoprene unit requires the input of 3 ATP.

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____________ is formed by the condensation of 6 activated isoprene units.

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Squalene is formed by the ___________ of _#_ activated isoprene units.

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Squalene is formed by the condensation of 6 activated __________ units.

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What is the metabolic cost of producing squalene from 6 activated isoprene units?

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_________ is cyclized to cholesterol.

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Squalene is __________ to cholesterol.

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Squalene is cyclized to ____________.

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.

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What is the metabolic cost of cyclizing squalene to cholesterol.

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What is the total metabolic cost to produce cholesterol from acetyl-CoA?

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4 NADPH and 3 ATP

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What is the metabolic cost to produce mevalonate from acetyl-CoA?

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Draw cholesterol backbone?

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Draw cholesterol backbone?

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What is the total metabolic cost to produce cholesterol from acetyl-CoA?

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4 NADPH and 3 ATP

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Steroids are made from what?

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Modifications to the cholesterol molecule.

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Steroids are made from what?

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Modifications to the cholesterol molecule.