Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
15 Cards in this Set
- Front
- Back
MHC Class II molecules interact with...
|
CD4 Cells
|
|
MHC Class I molecules interact with....
|
CD8 Cells
|
|
Which three signals are required for T-Cell activation?
|
- Interactions of MHC/Peptide with receptor
- Cd4/Cd8 stabilising - Co-stimulations |
|
Co-stimulatory Signals
|
- CD28 receptor on T-Cells
- Interacts with CD80/CD86 (or B7) on APCs. |
|
Dendrites
|
- Type of innate immune cell
- Long 'arms' increase S.A - Phagocytose - Stimulate T-Helper Cells - Process MHC Class II - Have lots of B7 molecules. |
|
Process of T-Cell Activation (From Dendritic Cells)
|
- Langerhan's Cells (dendrites in epidermal layers of the skin)
- Sit in a 'mesh-like' network. - Capture + pinocytose. - Process MHC Class II molecules. - Enter lymphatics and migrate to local lymph nodes. - Enter lymph node and become trapped. - Present MHC Class II to Naive T-Cells. - If correct T-Cell present --> Activation (remember lots of B7) |
|
What happens after T-Cells are activated?
|
Killers - will interact with MHC Class I and will undergo diapedesis and begin to kill infected cells.
Helpers: - Begin to secrete IL-2 (promotes T-Cell growth) and this has causes nearby similar T Cells to divide and also itself) = CLONAL SELECTION - Differentiate into T-Helper 1 or 2 Cells. |
|
T-Helper 1
|
- Intracellular bacteria and virus infections
- Activation is by IL-12 (produced by phagocytes, dsRNA detection, CpG island detection) |
|
T-Helper 2
|
- Extracellular toxins etc.
- Activation is by IL-4 (produced by Mast Cells) |
|
Cytokines of Th1
|
IFN Gamma
TNF alpha TNF beta IL-2 |
|
Cytokines of Th2
|
IL-4
IL-5 IL-10 |
|
IFN Gamma
|
Macrophage Activation
Class I and II Processing NK-Activation Complement |
|
TNF Alpha
|
Macrophage Activation
Extravasation |
|
TNF Beta
|
Macrophage Activation
Neutrophil Activation Tumor Killing |
|
IL-2
|
T Cell Growth
CTL Activation |