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12 Cards in this Set
- Front
- Back
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What are the main functions of T cells? |
To help B cells, kill virally infected cells, secrete cytokines, regulate immune responses
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What is the function of CD4 and 8? |
Help determine which MHC type a T cell receptor interacts with
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How do CD4+ helper T cells work? |
Secrete cytokines
Mainly against bacterial infections |
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How do CD8+ helper T cells work? |
Directly kill infected self
Mainly against viral infections |
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What is the interaction between TCR and MHC dependent on? |
Peptide dependent
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Difference between Ab and TCR? |
Ab recognise 3D structures on exposed surfaces
T cell receptors recognise small linear sequences on buried peptides |
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Draw the structure of a T cell receptor (TCR)
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Describe the structure of TCR |
2 pp chains - a (50 kD) and b (39 kD)
Constant and variable regions - MHC-antigenic binding site Gene rearrangement during development No somatic hypermutation |
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In gene rearrangement, how do alpha and beta segments differ? |
b chains have diversity segments |
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Comparing the TCR and BCR diversity |
More junctional and total diversity in TCR |
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What coreceptor is required for TCR? |
CD3 - gamma, delta, 2 epsilons and 2 zeta chains Transduces signal received by TCR and is comparable with Igab co-receptor on the B cell |
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What are the protein chains in TCRs? |
Humans, 95% ab, 5% gamma and delta |
