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260 Cards in this Set
- Front
- Back
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What are the teeth findings in hypomelanosis of Ito?
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Anodontia
Also see: marble-cake hypopigmentation epilepsy alopecia scoliosis mental/motor retardation |
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What is the MCC of diabetes-related yeast infections?
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C. albicans
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What two forms of GA have been implicated in diabetes? (although controversial)
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Generalized
Perforating |
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What is the MOA of cimetidine?
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competitively inhibits DHTat the androgen receptor site
Anti-androgen effects: loss of libido, gynecomastia |
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What are the major components of anchoring filaments?
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Laminin 5
BP180 |
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UVB acts on what compound to form pre-vitamin D3?
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UVB converts 7-dehydrocholesterol in the skin to pre-Vitamin D3, which then thermally isomerizes to form Vitamin D3.
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How long is the life cycle of the scabies mite?
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1 month
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Which diseases is the human body louse a vector for?
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Trench fever
epidemic typhus relapsing fever |
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What medications cause blue-gray pigmentation on sun-exposed areas but not sclerae, lunulae, or mucous membranes?
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Amiodarone
chlorpromazine tricyclic antidepressants |
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What are 3 types of melanoma-associated leukoderma?
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1) Analogous to halo nevus
2) Remote leukoderma distant from the primary lesion 3) vitiligo like leukoderma Hypomelanosis portends better prognosis |
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What is the major function of urocanic acid?
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Urocanic acid is a by product of filaggrin degradation
Has peak absorbtion of 345nm Functions as major UVA filter |
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What are features associated with atopic dermatitis?
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pityriasis alba
white dermatographism delayed blanch reponse anterior subcapsular cataracts keratoconus |
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What do Dermacentor variabilis ticks transmit?
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RMSF
Tularemia |
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What is the venom of the honeybee (Hymenoptera)?
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Phospholipase A
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What organism causes erosio interdigitalis blastomycetica?
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C. albicans
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Balanitis circinata presents as sharply demarcated, serpiginous ulcers or plaques on the penile head.
Balanitis circinata is usually seen in Reiter's syndrome which has a classic triad of arthritis, urethritis, and conjunctivitis. The syndrome typically occurs post-infection of the GI or urinary tract. |
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Which is the most common site for abdominal carcinoid tumors causing the classic carcinoid syndrome?
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Ileum
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What medications are associated with xerosis?
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HMG coA reductase inhibitors
Niacin Alter the lipid composition of the epidermis & SC Impair the normal barrier function of the skin |
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What is the MC photoallergen?
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Oxybenzone
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When do atypical mycobacterial infections typically occur after cosmetic procedures?
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4-14 weeks
Present as firm nodules at the treatment site or dehiscence of a previously healed wound |
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What retinoid targets RXR receptors?
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Bexarotene
Side effects: central hypothyroidism & hyperlipidemia Treat with: synthroid, lipitor, fenofibrate |
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What is the dermoscopic finding of hemangiomas?
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maroon lagoon or red sacculae appearance
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What are Odland bodies?
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Odland bodies (AKA lamellar granules)
Lamellated bodies containing ceramide Found intercellularly in upper level keratinocytes Discharge contents into the extracellular space at the junction of the granular and horny layers Barrier to water loss With filaggrin mediate stratum corneum adhesion Type of secretory granule with features of lysosomes |
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What phenotype results from a low activity of double stranded RNA adenosine deaminase?
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Dyschromatosis symmetrica hereditaria (or acropigmentation symmetrica of Dohi) is an autosomal dominant disease with hypo and hyper pigmented macules and patches on the dorsal hands and feet associated with a low activity of double stranded RNA adenosine deaminase
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Which vector transmits Borrelia duttonii?
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Causes relapsing fever
Transmitted by Ornithodoros moubata |
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What is a recently reported side effect of diode laser therapy?
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Reticulate erythema
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What wavelength range most effectively induces cutaneous immunosuppression?
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UVB: 290-320nm
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Acquired progressive kinking of the hair is associated with which medication?
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Retinoids
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What is the MCC eumycotic mycetoma in the USA?
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Scedosporium apiospermum (asexual stage)
Pseudallescheria boydii (sexual stage) |
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What is the primary component of human sebum?
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Triglycerides
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Distal subungual onychomycomycosis with associated paronychia is due to what?
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Scytalidium dimidiatum
Mold More often in fingernails than toenails |
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What causes black hairy tongue?
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Poor oral hygiene
Antibiotics HIV Tobacco Alcohol Radiation |
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Which antifungal does not require an acid environment and can work even when pt is on antacids?
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Fluconazole
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Which antihistamine has suppressor T cell inhibitory activity?
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Cimetidine
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Which cytokine is predominantly responsible for the Jarish-Herxheimer reaction?
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TNF alpha
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What vitamin deficiency is associated with scrotal dermatitis sparing the midline and extending to the thighs?
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vitamin B2 (riboflavin)
MC in alcoholics Oral-ocular-genital syndrome Also: angular cheilitis, atrophic glossitis (magenta), seborrheic-like dermatitis around the nose, photophobia, and blepharitis. |
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What malignancies are associated with EGR?
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Lung (MC)
Also: breast, cervical, bowel, and bladder cancer |
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When does tissue contraction occur in wound healing?
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During 2nd week
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When does hair follicle development begin in the embryo?
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3rd month
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Where are unbound corticosteroid receptors found in the cell?
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Cytoplasm
Estrogen receptors: nucleus Progesterone receptors: both the nucleus & cytoplasm |
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MCC death in DKC?
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Pancytopenia
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What is the treatment for glanders?
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Surgical excision of the lesion followed by streptomycin + tetracycline
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What causes glanders?
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gram-negative rod, Burkholderia mallei
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Multiple clear cell acanthoma are associated with what?
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Ichthyosis
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What syndromes are associated with poromas?
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Clouston's
Schopf-Schultz-Passarge |
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What benign adnexal neoplasm can cause necrosis en masse?
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Poroma
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Which B cell receptor is involved in Ig isotype switching?
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CD40
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Which syndrome is associated with a defect in the CD40 ligand?
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Hyper IgM
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What is the TOC for ENL?
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thalidomide
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What is the gene defect of hypohidrotic ectodermal dysplasia with immune deficiency ?
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NEMO
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Which type of epidermolysis bullosa has the greatest risk of developing squamous cell carcinomas?
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RDEB-HS type
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Which genodermatosis is associated with increased desmosine? decreased desmosine?
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Increased desmosine: Buschke-Ollendorf
Decreased desmosine: cutis laxa |
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Maple leaf-like structures seen on dermoscopy are characteristic of which lesion?
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pigmented BCC
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What type of UV rays are associated with immediate pigment darkening?
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UVA and visible light
Due to photo-oxidation of pre-existing melanin |
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What are Mee's lines?
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transverse white lines that affect all nails, grow out with nail growth
arsenic poisoning, rheumatic fever, CHF, leprosy, significant systemic disease |
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What lab abnormality is associated with mixed cryoglobulinemia associated with HCV?
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elevated rheumatoid factor
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What underlying malignancy is MC with hypetrichosis lanuginosa acquisita?
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Lung carcinoma
Abrupt onset of downy, soft, non-pigmented hair of the face, trunk, and extremities +/- glossitis |
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Hyperkeratotic follicular nasal papules have been described as a paraneoplastic sign in the setting of which neoplasm?
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Multiple myeloma
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What conditions are more commonly associated with Crohn's?
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Oral disease
Fissures and fistulae cutaneous metastatic disease PAN |
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What conditions are more commonly associated with UC?
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EN
pyoderma gangrenosum pyoderma vegetans |
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What meds cause photoonycholysis?
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Tetracyclines
Quinolones Psoralens Quinine |
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Gene defect in Mafucci's syndrome
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PTH receptor protein
Inceased risk of chondrosarcoma |
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Etiology of bullous tinea pedis
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T mentagrophytes
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Ananas comosus causes an irritant dermatitis attributed to which irritant?
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Bromelin
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Components of keratohyaline granules?
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Profillagrin
Loricrin |
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Toll-like receptor activated by P. acnes?
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TLR-2
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What determines differences in skin color?
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# and size of melanosomes
(# of melanocytes is same in all skin types) |
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Septate hyphae with 90� branching and thick walled barrel shaped arthroconidia alternating with empty cells best describes the microscopic morphology of?
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Coccidioides immitis
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Hutchinson's teeth are a feature of which stage of syphilis
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late congenital
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Plummer's nails associated with what disease?
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hypothyroidism
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MC cancer in Cowden's?
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breast cancer
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Main deterrent to staphylococcal infection of the skin ?
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neutrophils
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What type of amyloid loses birefrigence with potassium permanganate?
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Secondary systemic amyloid (AA) loses its birefringence after treatment with potassium permanganate
Not sure for amyloid in primary and localized forms |
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An infant with failure to thrive has multiple xanthomas on skin exam and foamy histiocytes on bone marrow biopsy--diagnosis?
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Neimann-Pick Type A
AR, sphingomyelin phosphodiesterase 1 |
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Palmoplantar keratoderma with deafness is caused by a defect in which gene?
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mitochondrial serine transferase RNA
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Defect in Papillon-lefevre and another disease with same defect
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cathepsin C lysososomal papain like cysteine proteinase
Haim-Munk |
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Cause of acrodermatitis chronica atrophicans?
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Borrelia afzelii
Transmitted by Ixodes ricinus |
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The main cytokine secreted by Th1 CD8+ effector T-cells
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IFN-gamma
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Which cytokine is the main macrophage-activating cytokine?
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ifn-gamma
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HLA associated with chronic idiopathic urticaria
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HLA -DR4, -DRB4 53, and -DQ8
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HLA associated w/ herpes simplex virus-related erythema multiforme?
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HLA-B15
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What is a chloroma?
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Granulocytic sarcoma
tumor of immature granulocytic cells Greenish discoloration due to MPO production |
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MC location for chloroma?
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Bone
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MC associated condition in chloroma?
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AML
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Risk factors for acquiring sporotrichosis?
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animal handling
alcoholism |
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Genetic disease associated with pretibial hyperpigmentation?
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Wilson's disease
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Surgical margin for Merkel cell carcinoma
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3cm
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A 43 year-old man with uncontrolled HIV disease presents with yellowish, red papules, draining sinuses and ulcers perianally and periurethrally. Which histopathological or immunohistochemical stain may aid in diagnosis?
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Von Kossa
Describes malakoplakia; Michaelis-Gutman bodies (calcified laminated intracytoplasmic bodies) |
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The first site in body that shows yellowish pigmentation in carotenoderma is?
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face
(Carotene is excreted by sebaceous glands and in sweat) |
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Psoriatic nail changes involving nail bed?
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salmon spots
oil spots onycholysis subungual hyperkeratosis splinter hemorrhages |
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Psoriatic nail changes involving nail matrix?
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pits
leukonychia |
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The proteins that make up the cornified cell envelope are synthesized in the:
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Spinous and granular layer
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MOA of denileukin diftitox?
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diphtheria fusion toxin that targets the IL-2 receptor
Systemic tx alternative for recalcitrant CTCL |
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Patients with x-linked icthyosis are more prone to getting which two malignancies?
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Testicular cancer
ALL |
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Which genetic defect could explain cutaneous findings in addition to abnormal immunoglobulin levels, recurrent respiratory infections, hypogonadism, and an increased risk of leukemia and lymphoma?
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RecQL3
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The most common laboratory abnormality in patients treated with isotretinoin is:
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hypertriglycerides
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A patient with Klinefelter Syndrome may be expected to experience which of the following:
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Recurrent leg ulcers (due to numerous varicosities)
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Which immunosuppressive drug binds iron and thereby significantly prevents absorption?
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mycophenolate mofetil
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Medications associated with IUD failure?
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NSAIDs
azathioprine |
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Receptor expressed by naive T cells?
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CD45RA
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Characteristics of XLR inheritance?
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Sons of carriers: 50% risk of being affected
Daughters of carriers have a 50% risk of being carriers. http:// |
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Characteristics of XLD inheritance?
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If father has disease, 100% of his daughters and 0% of his sons will have it
If mother has disease, 50% of sons and daughters will have it |
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What is the Weil-Felix test and which Ricketsial disease will be negative?
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Cross-reaction between antigens from the gram-negative Proteus vulgaris species and Rickettsia spp
Negative in Ricketssial pox |
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MC causative agent for ecthyma?
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GABHS
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How long after cutaneous infiltration of lidocaine with epinephrine is maximal vasoconstriction achieved?
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Vasoconstrictive effects of epinephrine:15 minutes to fully develop
Anesthetic properties of lidocaine: effect within minutes |
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A whitish, heaped and convoluted colony with growth submerged into the agar and a colorless reverse was isolated from the scalp of a 35-year-old male. The organism did not produce any conidia. The diagnosis most likely is:
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T. schonlenii
Produces a white cerebriform colony lacking any conidia |
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Which of the antiviral agents is NOT phosphorylated by viral thymidine kinase?
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cidofovir
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Primary cytokine that medidates Jarisch Herxheimer reaction?
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TNF alpha
Drug-induced effect caused by bacterial endotoxins or microbial antigens liberated by destruction of micoorganisms |
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Two subsets of subcutaneous panniculitis-like T cell lymphoma?
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1) CD8+, indolent course, alpha/beta TCR +
2) CD56+, gamma/delta TCR+, systemic hemophagocytosis, high mortality |
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Path finding in subctuaneous panniculitis-like T cell lymphoma?
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Bean bag cells
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Goblet cells are seen in which type of cyst?
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bronchogenic cyst
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Staging for SCC?
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T0: in situ
T1: <2cm T2: 2-4cm T3: > 4cm in diameter T4: invasive of muscle, cartilage, or bone |
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HPV type associated with periungual SCC?
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HPV 16
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Slimy, mucoid colony that produces urease?
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Cryptococcus neoformans
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Shoulder pad sign?
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Systemic amyloidosis (due to direction deposition of amyloid in deltoid muscles)
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Associations with Terry's nails?
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Diabetes
CHF cirrhosis |
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Genodermatosis associated with trichorrhexis nodosa and red fluorescence of the hair?
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Arininosuccinic aciduria
MR, physical retardation, convulsions, liver enlargement |
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sesquiterpene lactone is found in which plants?
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ragweed, pyrethrum, chrysanthemum, weeds, feverfew, and artichoke
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What does fillagrin break down into?
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Urocanic acid & Pyrrolidone carboxylic acid
Both hydrate the stratum corneum & block UV radiation (Major UVA filter, max absorption at 345nm) |
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What does this mutation in cystathionine beta-synthetase cause other than an accumulation of homocystine?
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abnormal crosslinking of collagen
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Itch is most commonly transmitted by which type of nerve fibers?
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C-polymodal nociceptor class nerves
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Which element is necessary for melanin production?
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copper
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Cutaneous warts in renal transplant recipients show increased expression of which keratin?
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K13
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The hair follicle is the site of production or conversion of which hormones?
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Testosterone to DHT via 5-alpha reductase
Cleaves proopiomelanocortin to ACTH, alpha-MSH, & B-endorphin via prohormone convertase Secretes CRH, prolactin |
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The finding on DIF that reflects binding of the Ro and La antigens in subacute cutaneous lupus erythematosus is:
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Granular fluorescence throughout the cytoplasm and nucleus of basal keratinocytes
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What is responsible for maintaining a barrier to water loss in the stratum corneum?
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Odland bodies
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Embryologically, epidermal stratification occurs at approximately what estimated gestational age?
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8 weeks
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On what cell type is CD14 expressed?
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Monocytes & macrophages
LPS binds to LPS binding protein and complexes with CD14 CD14 interacts w/ TLR4, which then activates NFkB |
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Type VII collagen in found in anchoring fibrils and also in:
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amnion
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Which signaling molecule mediates the transition of hair cycling from telogen to anagen phase?
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sonic hedgehog
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The formation of granulation tissue depends on the presence of? type of collagen making up granulation tissue?
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fibronectin
collagen III |
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When do melanocytes begin to synthesize melanin?
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3rd month of gestation
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The main permeability barrier in the lamina densa is?
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heparan sulfate proteoglycan
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Once a keratinocyte leaves the basal cell layer, the normal transit time to stratum corneum is at least?
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14 days
Then another 14 days transit time thru SC to desquamation |
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At what estimated gestational age are all layers of the keratinized epidermis identifiable?
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24 weeks
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On electron microscopy, which cell demonstrates cytoplasmic projections and secretory granules?
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mast cell
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All mononuclear phagocytic cells in the dermis express?
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CD6, CD11c
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free nerve endings found at the orifice of the hair follicle and particularly sensitive to cold?
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Papillary nerve endings
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mucocutaneous receptors found on the glans penis, clitoris, labia minora, perianal area, and vermillion border of the lips?
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Krause end bulbs
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The proteins that make up the cornified cell envelope are synthesized in what layer?
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spinous and granular cell layer
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What is the major component of lamellar granules of the keratinocytes?
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ceramides
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During embryogenesis, periderm cells of the fetus contain which of the following substances?
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glycogen
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Human sebum is distinguished from lipids of internal organs by the presence of?
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wax esters
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Retinoids upregulate transcription of which types of collagen?
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1 and 7
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The greatest density of mast cells is found in the?
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papillary dermis
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Meds that induce or exacerbate psoriasis?
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lithium, B-Blockers, antimalarials, and interferon
terbinafine, calcium channel blockers (nicardipine, nifedipine, nisoldipine, verapamil, and diltiazem), captopril, glyburide, and lipi-lowering drugs such as gemfibrozil |
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Children/adolescents with DLE are more or less likely to develop SLE?
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More likely
Also increased incidence of renal involvement |
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Which cytokine has been imnplicated in the etiology of dermatomyositis?
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TNF-alpha
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Ab associated with penicillamine-induced lupus?
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anti-dsDNA
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Which vascular disorder is characterized by facial vascular malformation and ipsilateral intracranial and retinal arteriovenous malformations(AVMs)?
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Bonnet Dechaune Blanc syndrome
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Eponym for cutis marmorata telangectasia congenita?
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Von Lohuizen's disease
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Inheritance and gene defect in orofaciodigital syndrome?
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XLD, CXORF5 gene
Malformations of the face, oral cavity, and digits Associated with polycystic kidney disease and variable CNS involvement (40%) |
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Which disease is found more commonly in mothers of patients with chronic granulomatous disease?
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discoid lupus, infections and apthous stomatitis
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Clinical features of Riley Day?
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hyperhidrosis, decreased corneal sensation and tear flow, hypersalivation, gastroesophageal reflux, decreased deep tendon reflexes, lack of pain sensation, absent fungiform papillae
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Gene defect in Beare-Stevenson cutis gyrata syndrome?
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Fibroblast growth factor receptor 2
craniosynostosis, ciutis gyrata, acanthosis nigricans, anogenital anomalies, skin tags, prominent umbilical stump, furrowed palms and soles |
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Gene defect in lymphedema-ptosis syndrome?
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MFH1
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MC ocular finding in CMTC?
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glaucoma
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The development of which malignancy is most commonly associated with lymphomatoid papulosis?
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mycosis fungoides, a CD30-positive large T-cell lymphoma or Hodgkin's disease
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Gene defect in Christ-Siemens-Tourraine syndrome?
|
Aka: anhydrotic ectodermal dysplasia
Ectodysplasin A |
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Palmoplantar keratoderma with deafness is caused by a defect in which gene?
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mitochondrial serine transferase RNA
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Cancers associated with Birt-Hogg-Dube?
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Renal cell carcinoma
Medullary thyroid carcinoma Colon carcinoma |
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The syndrome characterized by generalized mild hyperkeratosis, erythematous keratotic plaques, palmoplantar keratoderma, non-progressive sensorineural deafness, progressive bilateral keratitis with secondary blindness is:
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KID syndrome
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Hypoplasia of the breast can be seen in which disease?
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anhidrotic ectodermal dysplasia
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What nail change is seen in patients with Mal de Meleda Syndrome?
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subungual hyperkeratosis, koilonychia
|
|
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MC eye abnormality in Rothmund-Thomson syndrome?
|
40-50% of patients will develop juvenile cataracts before puberty
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Systemic complications in Hermansky-Pudlak?
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Bleeding diathesis
Pulmonary fibrosis Granulomatous colitis Cardiomyopathy Latter 3 due to accumulation of ceroid lipofuscin in macrophages |
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What are the 3 P's associated with Wiskott-Aldrich?
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Pruritus (atopic dermatitis), Purpura (thrombocytopenia leading to purpura and other bleeding) and pyogenic infections
|
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Which of the following syndromes is characterized by follicular atrophoderma, hypohidrosis, hypotrichosis and multiple basal cell carcinomas?
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Bazex syndrome
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MC malignancy associated with Li-Fraumeni syndrome?
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soft tissue sarcomas (among MC), breast caner, brain tumors, acute leukemia, and adrenal cortical carcinoma
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MCC tinea versicolor?
|
M. globosa
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Cause of positive blood culture in neutropenic patient with onychomycosis
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Fusarium
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Cause of tinea corporis gladiotorum
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T. Tonsurans
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Candida species likely to cause disseminated Candida with cutaneous lesions
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C. tropicalis
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Three causes of favus?
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T. schonlenii
T. violaceum M. gypseum |
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Organism responsible for bullous tinea pedis?
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T. mentagrophytes
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Amblyomma americanum (Lone Star Tick) associated with which diseases?
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RMSF, Tularemia, human monocytic ehrlichiosis
|
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Dermacentor spp. (Rocky Mountain Wood Tick) vector for which diseases
|
RMSF, Colorado Tick Fever (caused by an RNA arbovirus), Q fever, Tularemia, Ehrlichiosis & tick paralysis
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Ixodes scapularis--vector for what?
|
Lyme
Babesiosis Human granulocytic ehrlichiosis |
|
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Vector for Borrelia duttoni (relapsing fever)
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Ornithodoros spp
Can cause tick paralysis |
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Diseases carried by hedgehogs?
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T. mentag
Salmonella MAI, M. marinum |
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Diseases carried by flying squirrel?
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T. gondii
Staph Rickettsia prowasekii |
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Diseases carried by iguana?
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Serratia marcescens
Herpes type virus Salmonella |
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Diseases associated with chinchilla?
|
Colonized with:
Trichophyton mentagrophytes Microsporum gypseum Carriers of: Klebsiella pneumoniae Pseudomonas aeruginosa Immunocompromised esp. susceptible |
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Cockatoo transmits which disease?
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cryptococcus
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Sea cucumber toxin causing conjuctivitis?
|
holothurin
|
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Allergen in lichen?
|
D-usnic acid
|
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Vector for borrelia duttoni (relapsing fver)
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Ornithodoros
|
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MCC dermatitis in florists?
|
calcium oxalate (Narcissus, daffodil)
|
|
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Mechanism of blister formation after cantharidin?
|
disruption of keratinocyte-keratinocyte adhesion
|
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vector for babesia microti?
|
Ixodes dammini
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Medication associated with acquired brachial dyschromatosis?
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ACEI
Gray-brown patches with geographic borders, occasionally interspersed with hypopigmented macules |
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What is the difference between podophyllin and podophyllotoxin?
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Podophyllin, which has the same mechanism of action, contains kaempero and quercetin which are potent mutagens
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Primarily UVB blockers
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Salicylates, PABA, Padimate O, and cinnamates
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The endothelial ligand for cutaneous lymphocyte antigen (CLA) is?
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E-selectin
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cytokine responsible for woronoff ring?
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prostaglandin E2
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Main cytokine secreted by Th1 CD8+ effector T-cells
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ifn-gamma
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cytokine involved in isotype switching from IgM to IgE
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IL-13
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Cause of chromhidrosis?
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lipofusin
chromhidrosis = secretion of pigmented sweat, most commonly yellow, green or black Reflects lipofuschin content of apocrine sweat. |
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MC site of involvement of CP?
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Oral mucosa
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Best screening test for hemochromatosis?
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ferritin
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Three progestins with low androgenic potential
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Desogestril, norgestimate and gestodone
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Severe adverse reaction besides cardiotoxicity associated with phenol peel?
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laryngeal edema
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Which of the following is the major antioxidant in the human epidermis?
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alpha-tocopherol
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MC bacterial cause of purpura fulminans?
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GAS
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Culture medium for Leishmaniasis
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Novy-MacNeal-Nicolle (NNN) medium
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Cause of gastroenteritis after consuming contaminated seafood or shellfish
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Vibrio parahemolyticus
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IHC stains in DFSP
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nestin +, tenascin and stromolyesin negative
Opposite in DF |
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Two fungal infections associated with PEH
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blastomycosis, coccidiodomycosis
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Stain for inclusions in infantile digital fibroma
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Trichrome: stains red
PTAH NOT PAS |
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Ddx for Grenz zone
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Acroderm chronica
GF Lepromatous leprosy]Leukemia/lymphoma Colloid milium |
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Stains for AFX
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vimentin, CD99, procollagen, CD10
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HLA associated with pemphigus
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HLA-DRw6
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3 beta hydroxysteroid dehydrogenase mutated in what?
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CHILD
3 beta hydroxysteroid isomerase (EBP) in Conradi-Hunnerman |
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Gene defect in XLR chondrodysplasia punctata
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aryl sulfatase E
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What gene defect would you expect to find in a child with white forelock, dystopia canthorum, and upper limb abnormalities
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WS type 3
PAX3 |
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Subcutaneous panniculitis-like T-cell lymphoma with an indolent course is positive for which of the following?
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1) Indolent: CD8, alpha-beta TCR
2) Agressive: sometimes with evidence of systemic hemophagocytosis and high mortality. CD56-positive, gamma-delta T-cell receptor. |
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Histologic examination of cutaneous metastases from breast cancer is likely to demonstrate:
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tumor cells in the lymphatics
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An increased number of miniaturized hairs are seen in
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alopecia areata
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Which marker helps to differentiate extranodal NK-T cell lymphoma from cutaneous gamma delta lymphoma?
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Both cutaneous gamma delta lymphoma and extranodal NK-T cell lymphoma are CD56+. However, only extranodal NK-T cell lymphoma is EBV + while cutaneous gamma delta lymphoma is EBV negative.
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Intermittent sun exposure with painful sunburns is a predisposing factor for the development of:
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atypical nevi and melanoma
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The keratoacanthoma variant characterized by the sudden appearance during childhood or adolescence of multiple KAs is called:
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Ferguson-Smith
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What organism produces round thick walled spiny macroconidia and pear shaped microconidia?
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Histoplasma capsulatum
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The most sensitive microscopic test for fungal infection is:
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calcofluor white: glucan specific immunofluorescent stain
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Causes of relapsing fever
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Tick borne: Borrelia duttoni (Ornithodoros)
Louse-borne: Borrelia recurrentis (Pediculus humanis corporis) |
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Where do you see Gamma-Favre bodies
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LGV
Chlamydia trachomatis L1-3 Tx: doxy x 3 wks |
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A 43 year-old man with uncontrolled HIV disease presents with yellowish, red papules, draining sinuses and ulcers perianally and periurethrally. Which histopathological or immunohistochemical stain may aid in diagnosis?
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Von Kossa
Dx: malakoplakia Due to S. aureus, P. aeruginosa, or E. coli; characterized by Michelis-Gutmann bodies (foamy eosinophilic macrophages containing calcified, laminated, intracytoplasmic bodies) |
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Pili Annulati is associated with which syndrome?
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alopecia areata
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Proximal white subungual onychomycosis with polydactylous involvement needs at least one laboratory test
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HIV: means CD4 count is less than 450
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What do "oriental" and "bavarian" tiger balms react with respectively
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Oriental: Balsam of peru
Bavarian: rosin |
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A 47 year old park ranger developed a diffuse, erythematous, eczematous eruption after fighting a forest fire. What is the most likely allergen causing this airborn contact dermatitis?
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Lichen causes airborne allergic contact dermatitis in lumberjacks, forest workers, and people exposed to firewood, funeral wreaths, and masculine fragrances. The primary allergen is d-usnic acid.
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MCC ecthyma
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GABHS
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TOC for DFSP
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Mohs
WLE with 3cm margins |
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Gene defect in PAPA
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CD2 binding protein
pyogenic arthritis, pyoderma gangrenosum, acne |
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Cutaneous finding seen with thiotepa?
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hyperpigmentation in occluded areas, like axilla
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Chemo agents most likely to cause intense flushing
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dacarbazine and carmustine
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Chemo agent causing hyperpigmentation of the teeth with discoloration of the gingival margins
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cyclophosphamide
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Class of medications associated with acquired brachial dyschromatosis?
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ACEI
asymptomatic, gray-brown patches with geographic borders, occ w/ interspersed hypopigmented macules, on dorsal forearms, mostly bilaterally, in middle aged women. Epidermal atrophy, basal layer hyperpigmentation, elastosis and angiectases were histopathologic features. |
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Topical antibiotic that inhibits bacterial cell wall synthesis by complexing with the carrier protein C55-prenol pyrophosphatase.
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bacitracin
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Formation of granulation tissue depends on presence of what?
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fibronectin
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Frequent causes of anagen effluvium (chemo agents)
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doxorubicin, nitrosureas, cyclophosphamide
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most common genetic alteration seen in mucosal melanomas?
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KIT
seen in acral melanomas as well |
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Topical med associated with eruptive epidermoid cysts
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imiquimod
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Filler contraindicated in pt with h/o anaphylaxis or severe drug allergies?
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restylane
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Which topical antiseptic works via denaturation of proteins
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alcohol
Chlorhexidine, hexachlorophene, and triclosan disrupt the microbial cell membrane. Iodine and iodophores work via oxidation/substitution for elemental form of iodine, thereby precipitating proteins. |
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Paradoxical darkening has been associated with Q-switched ruby, Q-switched alexandrite, Q-switched Nd:Yag treatment of which tattoo color?
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white, red, flesh colored
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Which potential complications is seen exclusively with phenol peels
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laryngeal edema
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Criteria with worst prognosis for a patient with a squamous cell carcinoma?
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depth of invasion >4 mm and size > 2cm demonstrate the greatest risk for metastasis.
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Which anesthetic has the shortest duration of action?
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procaine
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Which of the following is the major antioxidant in the human epidermis?
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alpha tocopherol
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A patient undergoing Mohs surgery undergoes a rotation flap from the lateral canthus/cheek to close an infraorbital defect. What is the name of this flap?
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mustarde flap
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Which of the following is a complication of Thermage treatment?
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lipoatrophy
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Which organism causes peliosis?
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Peliosis hepatitis are seen in bacillary angiomatosis caused by Bartonella henselae which usually occurs in patients with AIDS.
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Cantharidin creates a vesicle by which of the following mechanisms
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isruption of keratinocyte-keratinocyte adhesion
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MC internal manifestation of systemic sclerosis
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esophageal dysmotility
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9-year-old boy presents with calcinosis cutis, periorbital violaceous erythema, and periungual telangiectasias. Which substance is most likely to be elevated in this patient?
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thrombospondin 1
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Antigen in LP pemphigoides
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BPAg2
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Maternal and fetal risk with impetigo herpetiformis
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Placental insufficiency
Mom: renal or cardiac failure |
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Presence of what sways melanin pathway towards pheomelanin
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cysteine
|
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Risk factors for post-transplant CTCL?
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renal transplant, cyclosporine, tacrolimus, and male sex.
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Dermatomyositis drug like reaction
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hydroxyurea
d-penicillamine phenytoni alfuzosin statins |
