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18 Cards in this Set
- Front
- Back
plt disorder vs coag factors
manifestations |
plt = petechiae
coag = hemarthroses |
|
intrinsic path
measured by initiated by affected by which drug |
measure PTT
initiate = exposure to collagen after vascular trauma affected by heparin |
|
extrinsic path
measured by initiated by affected by which drug |
measure PT
initiate = tissue factor from endothelium affected by warfarin |
|
factors affected by warfarin
|
protein C, prot S (causes initial hypercoag'y)
vit K dependent 1972 = 10, 9, 7, 2 |
|
cryoprecipitate
contains? |
factor 8, 9
vWF fibrinogen fibronectin |
|
hemophilia C
|
factor 11 deficiency
ashk jews |
|
secondary eosinophilia
causes |
NAACP
neoplasm, allergy, asthma, collagen vasc dx (Churg-Straus) parasites |
|
eosinophilic
normal level? cytokines? |
normal < 350
cytokines IL3, 5, GM-CSF |
|
primary eosinophilia
causes |
hyper-eosinophilic syndrome
hereditary eosinophilia eosinophilia - myalgia syndrome (abn tryptophan metab) |
|
elevated eosinophils
why analyze CSF? |
infection
coccidio-mycosis helminth |
|
hematuria with eosinophilia suggests?
|
schisto-somiasis
|
|
autologous transplant
allogenic syngeneic |
pt to self
donor to genetically diff pt btw identical twins |
|
matching with allogenic transplant
|
ABO
HLA |
|
pathomech for the 3 types of transplant rejection
|
hyperacute = immed = preformed ab's
acute = days - months = t-cell mediated chronic = months - years = chronic immune rxn --> fibrosis |
|
GVHD
graft vs host dx cause? presentation? |
allogenic transplant
donor T-cells attack host tissues presents with skin changes, cholestatic liver dysfn, obstructive lung dx, GI prob |
|
graft-vs- leukemic effect
|
leukemic pt, allogenic bone marrow transplant
signif lower relapse than those with autologous transplant due to rxn of donor Tcells against leukemic cells |
|
hemophilia
presentations |
spontaneous hemmorrhage
joints and tissues intracerebral retroperitoneal |
|
hemophilia
lab studies |
PT normal
PTT prolonged bleeding time normal thrombin time, fibrinogen norm factor assays (7, 8, 9, 11, 12) mixing studies - PTT returns to normal if hemophilia |