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11 Cards in this Set
- Front
- Back
After having an infection, a patient with Down's syndrome presents with increased WBC count (50,000) with increased neutrophils and a left shift, along with increased leukocyte alkaline phosphatase. What is the pathology?
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Leukemoid reaction.
Benign. A/W Down's, congenital heart malformation (tetrology of fallot), malignancy, or Kawasaki disease |
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A 66 y/o male presented with a low grade fever, night sweats, weight loss, and nontender LAD which felt firm and rubbery.
A biopsy was taken of a lymph node, and the above histology was noted. What is the diagnosis, and how does it spread in the body? |
This is a Reed Sternberg cell, characteristic of Hodgkin's lymphoma.
It spreads in a CONTIGUOUS manner. First, it will be localized to a single group of lymph nodes. Especially common in neck and mediastinum. Bimodal age distribution (1. Age 20, 2. Age 65) |
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A young child from Africa presents with a mandibular lesion. What is the translocation?
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This is the endemic form of Burkitt's lymphoma, which typically affects adolescents or young adults.
The sporadic form affects the pelvis and abdomen. T(8:14) - c-myc (8) and Ig heavy chain (14) A/W EBV. |
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A 17y/o M presents with enlarged inguinal lymph nodes. A biopsy was taken. What is the translocation?
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This is the classic "starry sky" appearance of Burkitt's lymphoma.
In the LNs, macrophages phagocytose some of the malignant lymphocytes, and clear a small area around them among the sea of lymphocytes. |
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Which is the most common Adult Non-Hodgkin's lymphoma? What is the translocation?
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Diffuse large B cell lymphoma.
t(14:18) in 20% of cases. |
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Mantle cell lymphoma translocation?
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t(11:14) - cyclin D1 (11) and Ig Heavy chain (14)
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Which NHL is a translocation of the c-myc oncogene and Ig heavy chain?
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Burkitt's lymphoma.
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Which NHL is a translocation of the cyclin D1 gene and the Ig heavy chain gene?
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Mantle cell lymphoma.
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Which NHL is the translocation of BCL-2 and Ig heavy chain?
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Follicular lymphoma.
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An adult presents with a hard neck mass, with a translocation of 14:18 - what is the diagnosis?
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Follicular lymphoma.
translocated Ig heavy chain (14) and BCL-2 (18), which inhibits apoptosis. Difficult to cure, indolent course. |
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A 68 year old woman presents to the clinic with the following cutaneous patches/nodules. What is the diagnosis? What is the pathophysiology?
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Dx: Mycosis fungoides/Sezary syndrome
Path: CD4+ T cells cutaneous proliferation. |