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11 Cards in this Set

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  • Back
After having an infection, a patient with Down's syndrome presents with increased WBC count (50,000) with increased neutrophils and a left shift, along with increased leukocyte alkaline phosphatase. What is the pathology?
Leukemoid reaction. 

Benign. A/W Down's, congenital heart malformation (tetrology of fallot), malignancy, or Kawasaki disease
Leukemoid reaction.

Benign. A/W Down's, congenital heart malformation (tetrology of fallot), malignancy, or Kawasaki disease
A 66 y/o male presented with a low grade fever, night sweats, weight loss, and nontender LAD which felt firm and rubbery. 

A biopsy was taken of a lymph node, and the above histology was noted. 

What is the diagnosis, and how does it spread ...
A 66 y/o male presented with a low grade fever, night sweats, weight loss, and nontender LAD which felt firm and rubbery.

A biopsy was taken of a lymph node, and the above histology was noted.

What is the diagnosis, and how does it spread in the body?
This is a Reed Sternberg cell, characteristic of Hodgkin's lymphoma.

It spreads in a CONTIGUOUS manner. First, it will be localized to a single group of lymph nodes. Especially common in neck and mediastinum.

Bimodal age distribution (1. Age 20, 2. Age 65)
A young child from Africa presents with a mandibular lesion. What is the translocation?
A young child from Africa presents with a mandibular lesion. What is the translocation?
This is the endemic form of Burkitt's lymphoma, which typically affects adolescents or young adults.
The sporadic form affects the pelvis and abdomen.

T(8:14) - c-myc (8) and Ig heavy chain (14)

A/W EBV.
A 17y/o M presents with enlarged inguinal lymph nodes. A biopsy was taken. What is the translocation?
A 17y/o M presents with enlarged inguinal lymph nodes. A biopsy was taken. What is the translocation?
This is the classic "starry sky" appearance of Burkitt's lymphoma.

In the LNs, macrophages phagocytose some of the malignant lymphocytes, and clear a small area around them among the sea of lymphocytes.
Which is the most common Adult Non-Hodgkin's lymphoma? What is the translocation?
Diffuse large B cell lymphoma. 

t(14:18) in 20% of cases.
Diffuse large B cell lymphoma.

t(14:18) in 20% of cases.
Mantle cell lymphoma translocation?
Mantle cell lymphoma translocation?
t(11:14) - cyclin D1 (11) and Ig Heavy chain (14)
Which NHL is a translocation of the c-myc oncogene and Ig heavy chain?
Burkitt's lymphoma.
Burkitt's lymphoma.
Which NHL is a translocation of the cyclin D1 gene and the Ig heavy chain gene?
Mantle cell lymphoma.
Mantle cell lymphoma.
Which NHL is the translocation of BCL-2 and Ig heavy chain?
Follicular lymphoma.
Follicular lymphoma.
An adult presents with a hard neck mass, with a translocation of 14:18 - what is the diagnosis?
An adult presents with a hard neck mass, with a translocation of 14:18 - what is the diagnosis?
Follicular lymphoma.

translocated Ig heavy chain (14) and BCL-2 (18), which inhibits apoptosis.

Difficult to cure, indolent course.
A 68 year old woman presents to the clinic with the following cutaneous patches/nodules. What is the diagnosis? What is the pathophysiology?
A 68 year old woman presents to the clinic with the following cutaneous patches/nodules. What is the diagnosis? What is the pathophysiology?
Dx: Mycosis fungoides/Sezary syndrome

Path: CD4+ T cells cutaneous proliferation.