Step 1 Drug Suffixes

Front 1

-conazole

Back 1

Antifungal

e.g. Ketoconazole

BUT closely related: metronidazole is an abx, and mebendazole is a microtubule inhibitor for worms.

Hint 1

Antimicrobial

Front 2

-cillin

Back 2

PCN

e.g. Methicillin, Ampicillin

Hint 2

Antimicrobial

Front 3

-cycline

Back 3

Antibiotic, protein-synthesis inhibitor.

e.g. Tetracycline, Doxycycline.

Hint 3

Antimicrobial

Front 4

-navir

Back 4

Protease inhibitor

e.g. Saquinavir, Ritonavir

Hint 4

Antimicrobial

Front 5

-triptan

Back 5

5-HT 1b/1d agonists (migraine)

e.g. Sumatriptan (Imitrex)

Hint 5

CNS

Front 6

-ane

Back 6

Inhaled general anesthetic

e.g. Halothane

Hint 6

CNS

Front 7

-caine

Back 7

Local anesthetic

e.g. Lidocaine, Tetracaine

Hint 7

CNS

Front 8

-operidol

Back 8

Butyrophenone (neuroleptic)

e.g. Haloperidol

Hint 8

CNS

Front 9

-azine

Back 9

Phenothiazine (neuroleptic, antiemetic)

e.g. Chlorpromazine, Thorazine

(atypical antipsychotic)

Hint 9

CNS

All atypical zines

Front 10

-barbital

Back 10

Barbituate

e.g. Phenobarbital

Hint 10

CNS

Front 11

-zolam

Back 11

Benzodiazepine

e.g. Alprazolan, Midazolam, Triazolam

Hint 11

CNS

Front 12

-azepam

Back 12

Benzodiazepine

e.g. Diazepam, Lorazepam

Hint 12

CNS

Front 13

-etine

Back 13

SSRI

e.g. Fluoxetine, Paroxetine

Hint 13

CNS

Front 14

-ipramine

Back 14

TCA

e.g. Imipramine, Tranylcipramine

Hint 14

CNS

Front 15

-triptyline

Back 15

TCA

e.g. Amitryptyline, Nortriptyline

Hint 15

CNS

Front 16

-olol

Back 16

ß-antagonist

e.g. Propranolol, Atenolol

EXCEPT cavedilol and labetalol, which also block alpha receptors.

Hint 16

Autonomic

Front 17

-terol

Back 17

ß2-agonist

e.g. Albuterol, Salmeterol

Hint 17

Autonomic

Front 18

-zosin

Back 18

alpha-1 antagonist

e.g. Prazosin, Doxazosin, Terazosin

Hint 18

Autonomic

Front 19

-oxin

Back 19

Cardiac glycoside (inotropic agent)

e.g. Digoxin

Hint 19

Cardiovascular

Front 20

-pril

Back 20

ACE inhibitor

e.g. Captopril, Lisinopril

Hint 20

Cardiovascular

Front 21

-afil

Back 21

Erectil dysfunction

phosphodiesterase inhibitor --> vasodilation.

e.g. Sildenafil, TADAlefil

Hint 21

Cardiovascular

Front 22

-tropin

Back 22

Pituitary hormone

e.g. Somatotropin

Hint 22

Other

Front 23

-tidine

Back 23

H2 antagonist

e.g. Cimetidine, Rimetidine

Hint 23

Other

Front 24

-bendazole

Back 24

Benzimidazole

e.g. Mebendazole, Albendazole

Hint 24

Helminths

Front 25

-chol

Back 25

Muscarinic agonist

e.g. Bethanechol, carbachol

Front 26

-curium

Back 26

Nondepolarizing neuromuscular blocker

e.g. Atracurium

Front 27

-curonium

Back 27

Non-polarizing neuromuscular blocker

e.g. Vecuronium, Rockuronium

Front 28

-dipine

Back 28

Dihydropyridine Ca2+ channel blocker

e.g. Nifedipine, Amlodipine

Front 29

-dronate

Back 29

Bisphosphonate
-osteoporosis

e.g. Alendronate

Front 30

-glitazone

Back 30

Thiazdidinedione (TZD)
- diabetes
- increase insulin sensitivity by binding to PPAR gamma receptor to increase gene transcription

e.g. pioglitazone, rosiglitazone (increased risk of MI).

Front 31

-mab

Back 31

Monoclonal Antibody

e.g. Infliximab

Front 32

-mustine

Back 32

Nitrosourea
- Nitrogen musctard
- brain cancer

e.g. lomustine

Front 33

-phylline

Back 33

Methylxanthine

e.g. theophylline, aminophylline

Front 34

-prost

Back 34

Prostaglandin analog
-glaucoma

e.g. Latanoprost, Travaprost

Front 35

-sartan

Back 35

ARB (Angiotensin-receptor blocker)

e.g. Losartan

Front 36

-statin

Back 36

HMG-CoA reductase inhibitor

e.g. Atorvastatin, Simvastatin

Front 37

-stigmine

Back 37

Anticholinesterase

e.g. Neostigmine, Physostigmine, Pyridostigmine.