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13 Cards in this Set
- Front
- Back
Name an example of an amine ergot alkaloid.
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Ergonovine
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Name an example of a peptide ergot alkaloid. (due to the cyclic peptide chemistry linked to its tetracyclic core ring system
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Ergotamine
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What is the name of the drug which is a synthetic congener of ergonovine and is abuse?
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LSD (lysergic acid diethylamide)
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What produces ergot alkaloids in nature?
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Claviceps pupurae, a fungus that infects grain and damp conditions. In humans, ingestion of this is a source of ergot poisoning.
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What are the two ergot alkaloid drugs which may be isolated from Claviceps purpurae?
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Amine alkaloids and peptide alkaloids
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How do ergot alkaloids function?
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They may function as agonist, partial agonist, and antagonist at alpha adrengeric receptors and serotonin receptors (mainly 5-HT1A and 5-HT1D), both centrally and peripherally
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Which ergot alkaloid has dopaminergic effects in the CNS and also inhibit the release of prolactin from pituitary cells?
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Bromocriptine
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Which drug causes prolonged and potent constriction of blood vessels?
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Ergotamine
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Ergotamine and Ergonovine
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Are partial agonist at both alpha-adrenergic receptors and 5-HT2 receptors.
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Ergot alkaloids stimulate or relax uterine smooth muscle?
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stimulate
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At lower doses, ergot alkaloids produce?
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rhythmic contraction and relaxation of the uterus
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At higher doses, ergot alkaloids cause
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forceful and prolonged contraction
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Which ergot alkaloid is the most selective for stimulation of uterine smooth muscle?
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Ergonovine
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