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13 Cards in this Set
- Front
- Back
SLE
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-multi-system AT disease of unknown etiology
-a "connective tissue" dz |
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typical lupus pt
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1. female
2. 15-45 3. F>M 4. can occur at any age 5. blacks and hispanics 2-4x more frequent |
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SLE classification criteria
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1. malar rash- rash across bridge of nose, raised or flat, do not effect nasolabial fold
2. discoid rash-raised patches 3. photosensitivity 4. oral ulcers 5. arthritis 6. serositis 7. renal disorder 8. neuro disorder 9. hematologic disorder 10. immunologic disorder 11. ANA |
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lab hallmark of SLE
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-ANA
->98% of pts with SLE have elevated serum levels of ANA -test is not specific for SLE -if ANA is +: 1. dsDNA 2. anti-SM 3. anti-histone 4. folow pts with LUPUS complement C3 and C4 |
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Labs
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1. CBC
2. ESR 3. U/A 4. RF 5. ANA 6. CPK 7. Chemscreen 8. thyroid functions |
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most common courses of death in lupus pts
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1. infx
2. lupus nephritis and renal failure 3. CV dz 4. CNA lupus -sever lupus is uncommon! |
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Anti phospholipid syndrome (APLS)
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-venous thrombosis
-arterial thrombosis -recurrent feta loss -thrombocytopenia |
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organ involvement in SLE
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1. joints- 90%
2. skin 3. serositis 4. kidney 5. raynauds 6. mucosa 7. CNA |
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raynauds phenomenon
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-must be 2 or 3 fold
-blue, red, white |
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CNS
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1. seizures
2. hemiparesis 3. CN lesions 4. stem/cord lesions 5. aseptic meningitis 6 transverse myelitis |
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PNS
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1. peripheral neuropathies
2. myasthenia gravis 3. mononeuritis multiplex- vasculitis assoc with lupus, causes and infarct |
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Psychiatric
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1. organic and non organic
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treatment
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1. NSAIDs
2. PLaquentil 3. Methotrexate 4. Steroids 5. Assess osteoporosis 6. sunscreens 7. immunizations |