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44 Cards in this Set
- Front
- Back
Atopic (eczematous) dermatitis |
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Contact dermatitis |
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Acne vulgaris |
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Propionibacterium acnes infection |
Produces lipase's that break down sebum, releasing pro inflammatory fatty acids; results in in pustule or nodule formation |
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Psoriasis |
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Possible autoimmune etiology of psoriasis |
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What does histology show in psoriasis? |
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Treatment of psoriasis |
Corticosteroids, UV light with psoralen, or immune-modulating therapy |
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Lichen planus |
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Pemphigus vulgaris |
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What causes suprabasal blisters in pemphigus vulgaris? |
Acantholysis (separation) of stratum spinosum keratinocytes (normally connected by desmosomes) |
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What causes the 'tombstone' appearance in pemphigus vulgarism? |
Basal layer cells remain attached to basement membrane via hemidesmosomes |
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Nikolsky sign |
Thin-walled bullae rupture easily, leading to shallow erosions with dried crust in pemphigus vulgaris |
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Bullous pephigoid |
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Dermatitis herpetiformis |
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Erythema multiforme |
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What causes erythema multiforme? |
HSV infection; other associations include Mycoplasma infection, drugs (penicillin and sulfonamides), autoimmune disease (e.g. SLE) and malignancy |
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Stevens-Johnson syndrome |
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Seborrheic keratosis |
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Leser-Trelat sign |
The sudden onset of multiple seborrheic keratoses and suggests underlying carcinoma of GI tract |
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Acanthosis nigricans |
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Basal cell carcinoma |
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How does BCC present? |
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What does histology show in BCC? |
Nodules of basal cells with peripheral palisading |
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Squamous cell carcinoma |
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Risk factors for squamous cell carcinoma |
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Actinic keratosis |
Precursor lesion of squamous cell carcinoma and presents as hyperkeratotic, scaly plaque, often on face, back or neck |
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Keratoacanthoma |
Well-differentiated squamous cell carcinoma that develops rapidly and regresses spontaneously; presents as a cup-shaped tumor filled with keratin debris |
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Vitiligo |
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Albinism |
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Melasma |
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Growth phases of melanoma |
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Dysplastic nevus syndrome |
Autosomal dominant disorder characterized by formation of dysplastic nevi that may progress to melanoma |
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Superficial spreading melanoma |
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Lentigo maligna melanoma |
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Nodular melanoma |
Early vertical growth; poor prognosis |
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Acral lentiginous melanoma |
Arises on palms or soles, often in dark-skinned individuals; not related to UV light exposure |
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Impetigo |
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Cellulitis |
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Verruca (wart) |
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Molluscum contagiosum |
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Staphylococcal scalded skin syndrome |
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How is staphylococcal scalded skin syndrome distinguished histologically from toxic epidermal necrolysis? |
by level of skin separation; separation in TEN occurs at the dermal-epidermal junction |
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Freckles occur due to an increased number of ____________ |
Melanosomes (not melanocytes!) |