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9 Cards in this Set
- Front
- Back
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Methylated tetrahydrofolate |
"C" Sushi on a bed of 4 leaves Transferring "C" sushi - thymidylate synthase = makes conversion of THF --> DHF and dUMP to dTMP 2 Leaves on boat = DHF Adding 2 leaves to make THF = Dihydrofolate reductase Adding "C" sushi = THF is remethylated |
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Methotrexate |
Meat stix Blocked leaf chef = irreversibly block dihydrofolate reductase (inhibits THF synthesis) Build up of DHF Cracked cancer crab = treats many cancers Emptying uterus bag = Can be used as an abortifacient Ectopic key chain = Treats ectopic pregnancy Dumped mole = treats molar pregnancy, trophoblastic tumors, choriocarcinoma Silver scale kneepads = treats psoriasis Rheumatoid lantern = first line treatment for rhematoid arthritis Torn antibody lamps = good for immunosuppressive therapy |
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Target of these drugs |
Sushi Phase = S phase Ramen noodles held by chop sticks = Blocks DNA (thymidine synthesis) |
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Methotrexate side effects |
Falling foliage = can cause folate deficiency Large RBC lights = megaloblastic anemia (folate) Depleted bone pan = myelosuppression and pancytopenia Cane = immunosuppression Fibrotic lung bonsai = pulmonary fibrosis Liver stain = hepatotoxicity Bald guy = alopecia (baldness) Poking mouth = mucositis |
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Leocovorin |
Lucky feline statue = folonic acid Reverse toxic effects of methotrexate Displaces methotrexate from binding sites and restores folate stores |
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5-Fluorouracil |
Full guy binding carbon donor Inhibits thymidylate synthase (blocks thymidine production) Buildup of dumpling plates = Increased levels of dUMP |
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5-Fluorouracil side effects |
Stained pants on full guy = Can cause diarrhea Sensitive photos =photosensitivity and hyperpigmentation Depleted bone pan = myelosupprssion and pancytopenia Cane = immunosuppression Knocked over lucky feline = leucovorin has no effect |
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Ribonucleotide reductase |
Crossed out OXY (converts UDP --> deoxy-UDP) |
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Hydroxyurea |
Hydro-rock area (ribonucleotide reductase inhibitor) Inhibited wait list waitress = inhibited ribonucleotide reductase (blocked thymidine synthesis) Cracked crab = Especially useful in solid and hematologic malignancies (AML, CML, head and neck cancers) Zen sickle = reduces veno-occlusive crises in sickle cell anemia Raised baby with hemoglobin coin = increases fetal hemoglobin levels |
