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6 Cards in this Set
- Front
- Back
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Phosphoribyl pyrophosphate (PRPP) |
Pentagon pedestal with 3 phosphate hammers (precursor to inosine monophosphate (IMP)) =precursor to AMP (grAMPs statue) and GMP(GrUMPy statue) |
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Azothioprine |
Aza-meralda (prodrug form of 6-mercaptopurine) Knocks over imp = blocks synthesis of IMP -->decreased purine nucleotide synthesis --> blocked DNA and RNA synthesis "Stairs out" = Blocks S phase Torn antibody lights = immunosuppressive therapy Rheumatoid lantern = Treats rheumatoid arthritis Inflamed colonic lanterns = treat inflmmatory bowel disease (crohn's and ulcerative cholitis) |
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6-mercaptopurine |
CAPTured gypsy Knocks over imp = blocks synthesis of IMP -->decreased purine nucleotide synthesis --> blocked DNA and RNA synthesis "Stairs out" = Blocks S phase Cracked archers, T knights, and crab = Treats hematologic malignancies (ALL in particular) Torn antibody lights = immunosuppressive therapy Rheumatoid lantern = Treats rheumatoid arthritis Inflamed colonic lanterns = treat inflmmatory bowel disease (crohn's and ulcerative cholitis) |
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Hypoxanthine - guanine phosphoribosyl transferase (HGPRT) |
HiGh PRiest prods captive = activates 6-MP |
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Side effects of AZA/6-MP/Mycophenolate mofetil |
Depleted birdseed on bone pan = Myelosuppression Cane = Immunosuppression Squeezed pancreas sponge = Pancreatitis Liver stain = Hepatitis Purine beads = inhibition of Xanthine oxidase increases levels of purine analogs causing increased risk of side effects due to allopurinol |
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Mycophenolate mofetil |
Quasi-mofetil (IMP dehydrogenase inhibitor) Topples GruMPy statue = inhibits IMP dehydrogenase --> decreased GMP synthesis --> decreased lymphocyte proliferation Torn antibody lantern = Useful for immunosuppressive therapy Rheumatoid lantern = Treat rheumatoid arthritis Nauseated hunchback = cause GI distress |
