Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
5 Cards in this Set
- Front
- Back
What is and ITAM?
|
immunoreceptor tyrosine base activation motif in cyctoplasmic domain of BCR and TCR signaling subunits
|
|
4 steps of BCR signal initiation?
|
1. ITAM phosporylation
2. recruitment of Src kinases and Syk 3. phosphorylation of adaptor proteins and scaffold proteins 4. Recruit SH2 domain signaling proteins |
|
5 steps of TCR signal initiation?
|
1. TCR engagement allows Fyn (Src kinase) to phosphorylate ITAMs
2. CD4/CD8 binding brings Lck, phosphorylates more ITAMs 3. ZAP-70 binds dually-phospd ITAMS 4. Lck phosphts ZAP-70 and increases it's kinase activity 5. ZAP-70 phosporylates adaptor proteins |
|
How many ITAMs does BCR IgA and IgB have?
|
2 total (one on each Ig)
|
|
How many ITAMs does TCR CD3 have and Zeta chains have?
|
3 on each Zeta chain. 1 on each CD3. Total of 10.
|