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8 Cards in this Set

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Sickle Cell Anemia:

- genetic disease that affects red blood cells in the body due to a mutation on the Hb gene


- Hb codes for a polypeptide of 146 amino acids which is a part of haemoglobin

Haemoglobin

- important protein component in red blood cells

Normal Gene vs. Mutated Gene: Codon

GAG GTG

Normal Gene vs. Mutated Gene: Transcription

GAG on mRNA GUG on mRNA

Normal Gene vs. Mutated Gene: Translation

Anticodon on CUC and amino acid glutamic acid on tRNA




Anticodon on CAC and amino acid valine on tRNA



Normal Gene vs. Mutated Gene: Haemoglobin

Hb^A Hb^S

Normal Gene vs. Mutated Gene: Phenotype

- normal donut shaped red blood cells


- sickle cell shaped red blood cells

Normal Gene vs. Mutated Gene: Effects

- carry oxygen efficiently but are affected by malaria




- do not carry oxygen efficiently but give resistance to malaria