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8 Cards in this Set
- Front
- Back
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Sickle Cell Anemia: |
- genetic disease that affects red blood cells in the body due to a mutation on the Hb gene - Hb codes for a polypeptide of 146 amino acids which is a part of haemoglobin |
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Haemoglobin |
- important protein component in red blood cells |
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Normal Gene vs. Mutated Gene: Codon |
GAG GTG
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Normal Gene vs. Mutated Gene: Transcription |
GAG on mRNA GUG on mRNA |
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Normal Gene vs. Mutated Gene: Translation |
Anticodon on CUC and amino acid glutamic acid on tRNA Anticodon on CAC and amino acid valine on tRNA |
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Normal Gene vs. Mutated Gene: Haemoglobin |
Hb^A Hb^S |
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Normal Gene vs. Mutated Gene: Phenotype |
- normal donut shaped red blood cells - sickle cell shaped red blood cells |
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Normal Gene vs. Mutated Gene: Effects |
- carry oxygen efficiently but are affected by malaria - do not carry oxygen efficiently but give resistance to malaria |
