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17 Cards in this Set
- Front
- Back
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major opportunistic infxns in early posttransplant period (1-6 months)
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HPV, CMV, EBC, Hep A,B,C, HIV
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CMV
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EGD if epigastric pain in posttransplant
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Solid organ transplants long term consequence
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non-hodgkin's B cell lymphoma
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tacrolimus vs cyclosporine
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both nephrotoxic
tacrolimu superior for improving graft suvival but increased DM, GI AE and seizures |
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Mycophenolate mofetil
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blocks guanosine nucleotides required for DNA; inhibits B and T cell proliferation
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indications for splenectomy in ITP
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3-6 months of steroids to maintain plt >30,000
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Posttransplant lymphoproliferative disorder
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EBV
MC in SB & lung transplants highest incidence w/n 1st year fevers/night sweats/LAD |
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Treatment of PTLD
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rituximab (anti-CD 20Ab)
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Management of tertiary hyperPTH
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2-5% after renal transplant
fatigue, bone pain, osteo elevated Ca, PTH Tx subtotal parathyroidectomy or total with auto-transplant |
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Secondary hyperPTH
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develops in ESRD after HD
resolves w/n 1 year of transplantation |
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Acute rejection
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T-cell mediated
related to organ-host human leukocyte antigen disparity treatment can save graft in 90-95% a/w with increased risk of chronic rejection |
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Acute cellular rejection of solid organ transplants
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activation of recipient T lymphocytes by graft-derived antigens
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Acute rejection
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usually occurs between 1-6 weeks after transplantation
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Side effects of cyclosporine
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posttransplant DM
HTN nephropathy hyperlipidemia |
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Side effects of tacrolimus
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similar risk of of nephropathy
less risk of hyperlipidemia/HTN |
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Daclizumab
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against CD25 (IL 2 receptor alpha chain)
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mycophenolate mofetil
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inhibits purine synthesis (replaced azathioprine)
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