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13 Cards in this Set
- Front
- Back
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5HT has been implicated in these disease states:
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Depression, anxiety, schizo, eating disorders, OCD, migraines, and panic disorders
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What are the major stores of 5HT? (4)
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Enterochromaffin cells, platelets, CNS (raphe nuclei), pineal gland
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How many 5HT receptor families are there?
What are 5HT 1,2, & 4-7? What is 5HT 3? |
7; Protein coupled. A 5HT gated ion channel
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About how many subtypes of each family are there?
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14
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What is the fxn of the 5HT1 receptors?
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They inhibit the release of 5HT
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What is the fxn of 5HT2 receptors?
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Vasoconstriction, dilates the heart muscle, CNS action
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What is the fxn of the 5HT3 receptors?
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They are present in the CNS vomiting center
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This 5HT-1 (one) partial agonist treats anxiety and depression?
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Buspir-ONE
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This 5HT1D agonist is used to to "Ma's" graine (migraine)?
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Sumatriptan
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This 5HT2A/2C antagonist is used for migraines, depression, and schizo
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Ketanserin
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This 5HT3 antagonist is used in chemo and induced vomiting?
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ondansetron
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This 5HT4 agonist is effective in nighttime acid reflux?
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Cisapride
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This 5HT transporter acts as an inhibitor. It is a common tx for depression, and OCD
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Fluoxetine
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