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28 Cards in this Set
- Front
- Back
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What enzyme takes ATP to cyclic AMP
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adenylyl cyclase
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What enzyme converts cAMP to AMP?
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cyclic AMP phosphodiesterase
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What does cyclic AMP activate?
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protein kinase A
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what are the properties of protein kinase A
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2 regulatory subunits, 2 catalytic subunits, when 4 cAMP molecules bind, catalytic subunits are activated and dissociate
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Gq
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activatest phospholipase c-beta and cleaves P14phospahte into IP3 and DAG DAG activates protein kinase C
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What are the two channels responsible for Ca balance in the cell and where are they
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Calcium/Na exchanger, 3 Na in for 1 Ca out Ca pump-requires ATP
can be pumped into ER, or mitochondria( H Ca symport) also calcium binding proteins |
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alpha 1 adrenergic receptor
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Gs and causes vasoconstriction
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alpha 2 adrenergic receptor
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Gi vasoconstriction
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beta
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Gq causes vasodilation
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What is the molecule that induces NO production?
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bradykinin
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Mitochondrial targeting
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string of positively charged residues every 3 residues so form an amphipathic helix
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ER retention signal
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KDEL on C terminus
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ER import
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string of nonpolar aa near N terminus
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nuclear import
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string of basic amino acids
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peroxisome import
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SKL on carboxy terminus
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Ran form in nucleus
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GTP bound
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Ran form in cytosol
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GDP bound
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glycolysis production
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2NADH
2ATP |
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Fatty acid degredation
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1 acetyl coA
1NADH 1FADH2 |
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Citric Acid Cycle
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3NADH
1FADH2 1GTP |
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Prader Willi
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15q11
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Angelman
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15q11
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Down Syndrome
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trisomy 21
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Patau Syndrome
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Trisomy 13
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Edwards Syndrome
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Trisomy 18
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Cri du Chat
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partial deletion of p arm 5
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DiGeorge, Velocardial-facial syndrome and Sprintzen syndrome
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22q11 deletion
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Cat eye syndrome
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4 copies of 22q11
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