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20 Cards in this Set
- Front
- Back
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filaments composed of actin and associated proteins
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Thin filaments
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dark, narrow line in center of H band (best seen in EM). Contains protein ____ which binds myosin and keeps them aligned
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M line, myomesin
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forms lattice anchoring thick fliaments in Z lines. Large protein(~ 2500 kDa)
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Titan
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from the German "Heller" which means light. narrow light region in the center of A band. No thin filaments are present. Major component is ________, which form ATP from phospho-creatine and ADP. Shortens with contraction. It is a bare zone in the middle of filament (ie no head projections). Found in the center of the sarcomere and has one line within it
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H band, Creatine Kinase
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large dark band formed by thick and thin filaments (myosin complex with AF present in some regions). Maintains same width during contraction. Shared boundary of terminal cisterna
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A band
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large light band composed of only thin filaments. Adjacent to Z line. Shortens with contraction. shared boundary of terminal cisterna
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I band
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attached to z lines and helps anchor thin filaments; template for determining length of thin filament
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Nebulin
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bundles thin filaments into parallel arrays and anchors them @ Z line. Found on the positive end of actin filament. In smooth muscle, it is present in dense bodies
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alpha actinin
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binds myosin and keeps them aligned at M line
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myomesin
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binds to free portion of thin filament; regulates length of sarcomeric actin filaments
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tropomodulin
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IF; attaches sarcomeres to each other and plasma. Shows up in RhabdoSarcoma
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desmin
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links laminin to actin filaments; reinforces and stabilizes sarcolemma during muscle contraction
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Dytrophan
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narrow, dark line in center of I band. Contains alpha actinin, which anchors thin filaments there. It delineates the length of the sarcomere. They get closer together with contraction. In smooth muscle, dense bodies are present instead
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Z line (Z disk)
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thick filaments contain only myosin II, which is composed of...
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2 heavy chains and 4 light chains
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_____ end of actin filament extends toward M line and is capped by actin-cappin protein
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Negative
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______ end of actin filament is bound to Z line by alpha actinin
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Positive
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What are the 3 proteins of thin filaments
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F-actin, tropomyosin, and troponin
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Tropomyosin
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forms filaments that bind with F actin. Intacts with troponin complex (Troponin-C binds calcium; troponin-T binds tropomyosin, troponin-I binds actin, preventing interaction between actin and myosin
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At rest, ____ complex blocks the myosin-binding site of F-actin
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troponin-tropomyosin complex
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Myofilaments composed of myosin II
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thick filaments
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