Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
47 Cards in this Set
- Front
- Back
Name the Large Vessel Vasculitides
|
Takayasu's arteritis
Giant cell arteritis/polymyalgia rheumatica Aortitis associated with an underlying inflammatory disease such as spondyloarthropathy, relapsing polychondritis, or retroperitoneal fibrosis |
|
Name the Medium Vessel Vasculitides
|
Polyarteritis nodosa
Churg-Strauss syndrome Kawasaki disease |
|
Name the Small Vessel Vasculitides
|
Wegener's granulomatosis
Henoch-Schönlein purpura Leukocytoclastic vasculitis Microscopic polyangiitis Cryoglobulinemic vasculitis Primary angiitis of the central nervous system Vasculitis associated with connective tissue diseases |
|
T/F Pt's with antiphospholipid syndrome have a prolong PTT, therefore they have a tendency to clot
|
TRUE
They have a lupus antigen |
|
What is the treatment for vasculitides?
|
Steroids
DMARDS- immunosupressive drugs |
|
How do you diagnose vasculitis?
|
Angiograms- shows aneurysms
Biopsy |
|
a cutaneus finding with a fishnet-like appearance is suggestive of?
|
Livedo Reticularis
|
|
Name examples of Type I allergic reactions
|
Angioedema
Urticaria with erythema |
|
which type of hypersensitivity Rxn is antibody(IgG,IgM) mediated?
|
Type II
|
|
which type of hypersensitivity Rxn is cytotoxic, IgG, IgM, or complement mediated?
|
Type III
|
|
which type of hypersensitivity Rxn is a delay reaction T-cell mediated?
|
Type IV
|
|
Which viruses are assoc with Polyarteritis Nodosa
|
Hep B and C
|
|
What other diseases are assoc with vasculitis?
|
Infective endocarditis
Syphilis-meningial vascular syphilis Lupus Antiphospholipid syndrome |
|
MC type of systemic vasculitis?
|
Giant cell arteritis, AKA Temporal arteritis
|
|
Which population is at risk for GCA?
|
> 50 years
Females |
|
What are the symptoms of GCA?
|
Headaches
visual disturbance jaw pain arthralgias > ESR Anemia Fever |
|
What disease often coexist with GCA?
|
Polymyalgia rheumatica
|
|
Pain and stiffness of the shoulder and hip girdles and proximal extremities suggests?
|
Polymyalgia rheumatica
|
|
How is GCA confirmed?
|
Biopsy
|
|
How is GCA and PMR treated?
|
GCA-High dose steroids 6-12 mo
PMR-low dose steroids |
|
This disease results in stenosis of the aorta and its main branches, including involvement of the cerebral, brachiocephalic, renal, mesenteric, femoral, and coronary arteries
|
Takayasu's arteritis
|
|
What are the symptoms of Takayasu's arteritis?
|
Limb pain
Lightheadedness B symptoms: malaise, fever, arthralgias |
|
How do you diagnose Takayasu's?
|
Conventional angiography
|
|
How do you treat Takayasu's?
|
Glucocorticoids
Methotrexate Cyclophosphamide |
|
A medium vessel vasculitis involving segmental necrotizing lesions, often at arterial branch points, leading to stenoses, aneurysms, thromboses, infarction, or hemorrhage
|
Polyarteritis Nodosa
|
|
How do you treat PAN?
|
glucocorticoids
immunosuppressive agents antiviral therapy (pts with Hep B&C) |
|
This is a medium and small vessel vasculitis AKA allergic granulomatosis and angiitis
|
Churg-Strauss syndrome
|
|
What are the MC sites affected by Wegener's Granulomatosis?
|
sinuses
upper airway lungs kidneys |
|
IgA deposition in glomerular lesions is characteristic of this disease
|
Henoch-Sscholein Purpura
|
|
A middle-aged person with chronic asthma who develops pulmonary infiltrates, vasculitis, and eosinophilia. What's the likely diagnosis?
|
CSS
|
|
What are the S/Sx of Henoch-Schonlein purpura?
|
palpable purpura
arthritis abdominal pain fever glomerulonephritis |
|
What is the treatment of HSP?
|
Usually supportive and NSAIDS
Occasionally steroids and immunosuppressants |
|
What is the "gold standard" for the diagnosis of any vasculitis?
|
Biopsy
|
|
palpable purpura that can be seen in most of the medium and small vessel vasculitides
|
Leukocytoclastic vasculitis
|
|
How do you treat LCV?
|
Discontinue nonessential medications because many cases are drug induced
|
|
A biopsy from a pulmonary nodule shows granulomas with palisading histiocytes and giant cells. What is the diagnosis?
|
WEGENER'S GRANULOMATOSIS
|
|
What lab findings are useful in diagnosing vasculitis
|
UA- show RBC cast(glomerulonephritis)
ANCA eosinophilia elevated acute phase reactants |
|
ANCA is assoc. with which types of vasculitides?
|
Wegener's Granulomatosis
Microscopic polyangiitis CSS (allergic granulomatous vasculitis) |
|
What is a side effect of chronic steroid use?
|
Osteoporosis
|
|
Which population is most affected by Kawasaki's disease?
|
young children
|
|
What are the S/Sx of Kawasaki's?
|
Swollen hands, lips, mouth, conjunctivitis, and coronary aneurysms
|
|
What is the treatment for Kawasaki's?
|
IV gamma globulin
Aspirin |
|
Aortitis with older individuals suggests?
|
Takayasus's
|
|
What is the pathophysiology of Systemic scleroderma?
|
(1) a metabolic defect in fibroblast metabolism leading to overproduction of collagen and other matrix proteins
(2) vascular injury and obliteration (3) immune cell activation and autoimmunity |
|
Which type of scleroderma has skin thickening on just the fingers, toes, and the face.
|
limited scleroderma
|
|
Name examples of DMARDs
|
Gold Salts
Methotrexate Azathioprine Sulfasalazine Hydrochloroquine |
|
What are the side effects of DMARDs?
|
Bone marrow suppression
|