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19 Cards in this Set
- Front
- Back
How is rheumatoid arthritis defined?
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A diffuse, chronic, systemic inflammation of connective tissue.
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Rheumatoid arthritis selectivity targets what tissue?
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Synovial tissue
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Rheumatoid arthritis may affect what other tissues?
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- Muscle
- Bone - Heart - Lungs - Blood vessels |
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Rheumatoid arthritis affects the joint unilaterally. True or False?
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False. It effects joints bilaterally.
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In 50-80% of patients, what joints are effected by Rheumatoid arthritis?
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- wrists
- elbows - ankles - knees - cervical spine |
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At what age is the onset of Rheumatoid arthritis most typical?
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20-60 years of age, with a peak between 40-50.
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What gender is 3x more likely to get Rheumatoid arthritis?
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Women
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When someone has Rheumatoid arthritis, what is happening on a cellular level?
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There is an inflammatory autoimmune reaction of the synovial tissue
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What antibody does the synovial fluid and blood of up to 70% of Rheumatoid arthritis patients contain?
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The antibody Rheumatoid Factor
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What is "pannus" tissue?
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Proliferating synovial tissue, where granulation tissue covers the normal surface of synovial tissue.
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What pathologic conditions occur in joints with Rheumatoid arthritis?
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- soft tissue swelling
- loss of joint space - bone erosion - osteoporosis |
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What clinical features are present in a patient with Rheumatoid arthritis?
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- Fatigue, malaise, general muscle weakness, low grade fever.
- insidious onset of pain - Morning stiffness - enlarged joints - tender joints - painful on motion of joints - warm and red joints - In chronic cases, joints are indurated and stiff |
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In a blood panel, what would the doctor find?
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The Anti-cyclic Citrullinated Peptide Antibody (ACCPA), which is 100% specific for Rheumatoid arthritis.
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On an x-ray, what pathologic changes would the doctor see?
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- soft tissue swelling
- marginal erosion - uniform loss of joint space - juxta-articular osteoporosis |
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In the hand, what joints are affected by Rheumatoid arthritis?
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The MCP joints, which cause ulnar deviation.
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In the wrist, what joints are affected by Rheumatoid arthritis?
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The carpals
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What other joints in the body are affected by Rheumatoid arthritis?
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- knees
- feet - cervical spine in 50-80% of chronic patients - Odontoid erosion, with damage to the transverse ligament, causing atlanto-axial instability. |
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If a doctor had a blood lab test peformed what would be found?
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- In 80% of patients, there would be a positive Rheumatoid Factor
- elevated erythrocyte sedimentation rate (ESR) in 90% of patients - Anemia in 80% of patients - +C Reactive Protein |
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What is the treatment for Rheumatoid arthritis?
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- Acute Stage: rest and anti-inflammatories
- In the non-inflammation state: manipulation and exercise - Improved diet |