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21 Cards in this Set
- Front
- Back
t/f pharyngitis can be dx clinically
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false
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giving a pt antibiotics with pharyngitis will relieve their symptoms right/
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nooooo
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Clinical manifestations of strep pharyngitis
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abrupt onset of sore throat
nausea vomitting and above 102.5 fever red edematous pharynx, tonsils small focal or confleunt areas of yellow/gray exudate |
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define scarlet fever
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grp a strep lyosgenized with bacteriophage that induces production of erythogenic toxin
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3 characteristics of scarlet fever
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strawberry tongue
diffuse erythmatous rash desquamation of skin 1 wk after onset |
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the two post strept sequelae
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acute rheumatic fever
acute glomerulonephritis autoimmune pathogensis |
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s pyogenes, characteristics
gram ferment glucose to ___ catalase ___ sensitive to ____ |
gram negative cocci chains
facultative anaerobes glucose to lactose catalase neg sensitive to bacotracin |
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SpyCEP does---
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inactivates IL-8, soluble virulence factor of strep pyogenes
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Describe the pathogensis of strep pyogenes
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Encounter----Spread-----Damage
direct contact or inhale nuclei attach to mucosal epithelial cells by fibrils or M protein/ lipteichoic acid resist phag (capsule and M protein) invade tissue (enzymes) intense inflammatroy respones hemolysins and enzymes |
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Lab DX for s pyogenes
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plate specimen on SBA
apply bacitracin, look for inhibition remember! 5% resistant to bacitracin |
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Tx for s pyogenes/strep pharyngitis
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Penicillin G or V for 10 days
Macrolides (erythromycin) or cephalosporins |
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Can early tx be counterproductive in strep pharyngitis?
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yes, less time for develop antibodies and less tissue penetration with antiboitics
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Diptheria is transmitted via
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droplet nuclie
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"bull neck" is seen in
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Diptheria
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sx for diptheria
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sore throat, fever-- pallor, listlessness, tachycardia
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Characteristics of C. diphteriae
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club-shaped or Chinese letters
stain with methylene blue, beaded appearnce, garlic odor in culture |
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c. diphteriae is stained with
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methylene blue
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"chinese letters"
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corynebacterium diptheriae
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exotoxin in c. diptheriae is due to
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lysogenic beta phage with tox+ gene
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MOA of toxin in C. diptheriae
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B fragment binds to receptors, endocytosis
toxin cleaved by protease A fragment enters cytoplasm blocks protein synthesis by ADP ribosylating elongation factor 2` |
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TX and prevention for diptheriae
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passive immune with antitoxin
penicilin immune with toxoids |