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24 Cards in this Set
- Front
- Back
FSH
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stimulates growth of follicles (FSH receptors on granulosa cells --> stimulates primary follicles --> stimulates aromatiziing enzymes to make estradiol --> estradiol increases FSH receptors --> oocyte grows and completes M1)
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LH
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induces ovulation 36 hrs after release/24 hrs after peak (continuation of meiosis, luteinization of granulosa cells, prostaglandin synthesis for digestion of follicular wall); stimulates steroid synthesis in ovary (C-27 cholesterol to C19 androgen, androstenedione)
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Estradiol (E2)
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negative feedback to pituitary to suppress FSH release (low levels); stimulates release of LH (high levels); puberty (menarche, anovulatory cycles, corpus luteum devo); fertile life (prolif of endometrium, withdrawal bleed), pregnancy (sustained uterine growth, mammary gland devo), menopause (preceded by anovulatory cycles, vasomotor flashes), post menopause (maintenance of female sex organs, bone loss)
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Estrone (E1)
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other forms of estrogen (see estrogen fxns)
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Estriol (E3)
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other forms of estrogen (see estrogen fxns)
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Progesterone
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prepares endometrium for implantation (luteal), prevents maternal immune rejection of trophoblast (inhibits production of cytolytic cytokines), smooth muscle relaxant (constipation, GI reflux), uterine quiescence (prevents oxytocin receptors + gap junction formation until onset of labor), inhibits ovulation
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GnRH
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pulsative; causes pulsatile release of LH/FSH from pituitary
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hCG
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maintains corpus luteum; finds to LH/CG rectpro to activate adenylyl cyclase and leads to steroidogenesis, binds to TSH receptors
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Anti-Mullerian Hormone
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causes paramesonephric ducts to degenerate, causes a continuous duct system, makes Leydig cells make testosterone
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Prostaglandins
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mediator of labor; E/F, receptors in decidua/myometrium
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Oxytocin
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mediator of labor; potent uterine stimulant, receptors in myometrium, fetal membranes (amnion), decidua
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Other labor mediators
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progesterone (decrease allows increased levels of PGF2 alpha; reduced uterine levels may preceed labor), estrogen (myometrial hypertrophy, upregulates gap junctions + oxytocin receptors), cortisol (from fetus, may trigger labor)
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FSH
|
stimulates growth of follicles (FSH receptors on granulosa cells --> stimulates primary follicles --> stimulates aromatiziing enzymes to make estradiol --> estradiol increases FSH receptors --> oocyte grows and completes M1)
|
|
LH
|
induces ovulation 36 hrs after release/24 hrs after peak (continuation of meiosis, luteinization of granulosa cells, prostaglandin synthesis for digestion of follicular wall); stimulates steroid synthesis in ovary (C-27 cholesterol to C19 androgen, androstenedione)
|
|
Estradiol (E2)
|
negative feedback to pituitary to suppress FSH release (low levels); stimulates release of LH (high levels); puberty (menarche, anovulatory cycles, corpus luteum devo); fertile life (prolif of endometrium, withdrawal bleed), pregnancy (sustained uterine growth, mammary gland devo), menopause (preceded by anovulatory cycles, vasomotor flashes), post menopause (maintenance of female sex organs, bone loss)
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Estrone (E1)
|
other forms of estrogen (see estrogen fxns)
|
|
Estriol (E3)
|
other forms of estrogen (see estrogen fxns)
|
|
Progesterone
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prepares endometrium for implantation (luteal), prevents maternal immune rejection of trophoblast (inhibits production of cytolytic cytokines), smooth muscle relaxant (constipation, GI reflux), uterine quiescence (prevents oxytocin receptors + gap junction formation until onset of labor), inhibits ovulation
|
|
GnRH
|
pulsative; causes pulsatile release of LH/FSH from pituitary
|
|
hCG
|
maintains corpus luteum; finds to LH/CG rectpro to activate adenylyl cyclase and leads to steroidogenesis, binds to TSH receptors
|
|
Anti-Mullerian Hormone
|
causes paramesonephric ducts to degenerate, causes a continuous duct system, makes Leydig cells make testosterone
|
|
Prostaglandins
|
mediator of labor; E/F, receptors in decidua/myometrium
|
|
Oxytocin
|
mediator of labor; potent uterine stimulant, receptors in myometrium, fetal membranes (amnion), decidua
|
|
Other labor mediators
|
progesterone (decrease allows increased levels of PGF2 alpha; reduced uterine levels may preceed labor), estrogen (myometrial hypertrophy, upregulates gap junctions + oxytocin receptors), cortisol (from fetus, may trigger labor)
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