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37 Cards in this Set
- Front
- Back
uterine aspriation
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electric/manual vacuum aspiriation;
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medical abortion
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abortion caused through medicines including mifepristone/misoprostol or methotrexate/misoprostol or misprostol alone
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mifepristone (RU486)
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anti-progestin (blocks progesterone as a type 2 antagonist; ligand binds to receptor --> complex binds to HRE --> recruits co-repressor --> no gene transcription); decidual necrosis, rhymic uterine contractions, cervical ripening --> detachment/expulsion
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misoprostol
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prostaglandin e1 analog; causes uterine contractions; softens + primes cervix, prevents/treats ulcers, can lead to nausea/vomitting, diarrhea, fever, and chiills
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methotrexate
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anti-folate --> blocks division of rapidly diving cells by inhibiting DNA synthesis --> affects cytotrophoblast ccells and impairs implantation
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Instillation
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instill fluid into uterus to increase in girth and lead to contractions
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Induction
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prostaglandins + oxytocin as needed; deliver intact fetus w/ procedure for extraction of placenta
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Dilation + Evacuation (D+E)
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cervical prep (osmotic dilators like laminaria japonica, lamicel, dilapan; exert gentle radial pressure on endocervical canal, increase release of prostaglandins, pharmacological agents like mifepristone + misoprostol); suction and extraction to remove pregnancy parts; feocidal techniques with injectons of Kcl or digoxin)
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PDE 5 Inhibitors
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cGMP phosphodiesterase inhibitors (stops breakdown); maintain vasodilator response (still need nerves to initiate)
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Ethinyl estradiol/mestranol
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estrogen
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equilin/equilenin
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estrogen
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raloxifene
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SERM (selective estrogen receptor modulator) type 3; SERM binds to ER --> complex binds to estrogen response element in the nucleus --> conformation of complex determines whether an activator or a repression
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tamoxifen
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SERM (selective estrogen receptor modulator) type 4
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letrozole, vorozole, arimidex
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aromatase inhibitor (anti-estrogen)
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norethindrone
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progestin
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17B-esters of testosterone
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ong acting, potent synthetic complete androgen
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17a-alkylated androgens
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less potent as androgens than B; anabolic
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cyproterone acetate
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steroidal androgen receptor antagonist
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flutamide
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non-steroidal androgen receptor antagonist
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finasteride (proscar)
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5-alpha reductase inhibitor type 2
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leuprolide/Zoladex
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LH-RH agonist
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Male Condom
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barrier (latex, polyurethane, sheep membrane)
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Spermicides
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chemical barrier, nnoxynol-9 + delivery base (surfactant that disrupts sperm membrane
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Cervical Cap
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plastic cap fit into cervix
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Copper IUD (Permaguard)
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alters membrane and prevents gametes from implanting
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fertility awareness based methods
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most likely to get pregnant 6 days before to 1 day after ovulation
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Yuzpe regimin
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emergency contraception; 2 doses of EE w/ norgestrel given 12 hrs apart; first dose w/i 120 hrs of unprotected intercourse
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Progestin-only pill/plan B/levonorgestrel
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emergency contraception; 1 doese of 1.5 mg EE w/i 120 hrs of unprotected sex
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Ulipristal acetate (ella)
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progesterone receptor modulator that's likely to inhibit or delay ovulation
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Estrogen + Progestin OC
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progestin (inhibits LH surge/ovulation, thickens cervical mucus, endometrial atrophy); estrogen (inhibits FSH surge, follicle devo, thins cervical mucus, increases endometrial proliferation); less androgen stimulation (less free T/DHT --> lower LH/FSH --> less AR stimulation --> decreased acne/hersitism
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Extended Cycle Pill (Seasonale)
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levonogestrel +EE
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365-day pill
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levonogestrel +EE
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contraceptive patch
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norgestimate + EE
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Vaginal Ring
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eonogestrel + EE
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Levonorgestrel IUD (Mirena)
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levonogestrel (progestin only IUD)
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Implanon
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etonogestrel in implant under arm (no estrogen)
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olaparib
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PARP inhibitor (PARP usually helps with base excision repair; lack of PARP allows normal cells to survive b/c of other repair mechanisms but potentially cancerous cells die b/c they can't repair their DNA)
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