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23 Cards in this Set
- Front
- Back
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hormones from anterior pituitary
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FLAT PiG
FSH LSH ACTH TSH Prolactin GH |
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GH functions
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anti-insulin
fat utilization at expense of protein |
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GH regulation
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stim by GHRH
inhib by somatostatin (also inhibits TSH) feedback inhibition & IGF inhibition synergistic w/TH affected by hypothal tumors |
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disorders involving GH
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hypothal tumor (defic)
gigantism & acromegaly (excess) |
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TSH subunit w/low specificity
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alpha subunit
shared by LH, FSH, HCG |
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hypothal stim of ACTH
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CRH
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production of cortisol
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CRH from Hypothal
ACTH from ant pit activate POMC pathway (also produce endorphins, lipotropin, melanocyte stim hormone) |
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hypothalamic regulation of prolactin
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DA inhibits
hypothal (GRH, TRH) & estrogen (systemic) stimulates |
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prolactin excess
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amenorrhea & galatorrhea in women
ED, impotence in men |
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hypothalamic regulation of LH & FSH
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(gonadotropins)
GnRH stims testost, estro & progest inhibit |
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functions of oxytocin
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milk letdown
uterine ctx maternal nurturing behaviors |
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regulation of oxytocin
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stim by nipple stim
inhib by catecholamines |
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hypothalamic peptides acting on pit
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GnRH
CRH TRH GHRH |
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severed stalk of pit will suppress...
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all ant pit hormones EXCEPT prolactin
"hypophysiotropic hormones" |
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hypophysiotropic hormones
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TSH, GH
LH, FSH, ACTH |
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stimulators of ADH
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osmoreceptors (hypothal)
baroreceptors (atrial & carotid) nausea nicotine, mophine AT II hypoxia, hypercapnea |
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acidophilic cells
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somatotroph (GH)
Lactotroph (prolactin) somatomammotroph (GH, Prolac) |
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basophilic cells
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corticotroph
gonadotroph (LH, FSH) thyrotroph |
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mech of stim of cortisol production
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CRH stim
ACTH causes cAMP activation of cortisol, aldosterone, androgens |
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somatomammotropins
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GH
prolactin placental lactogen |
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peptide hormone families
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somatomammotropins
(GH, Prolactin, Placental Lactogen) corticotropins (ACTH, MSH, LPH, endorphin) glycoproteins (TSH, LH, FSH, hCG) |
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tx for pit insuff
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essential hormones
-TSH -ADH -Cortisol QOL hormones -estrogen -testosterone |
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tx for pit adenomas
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prolactinomas
-Bromocriptine (DA agonist) GH & TSH -octreotide (somatostatin analog) surg, irrad |
