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3 Cards in this Set
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- Back
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collagen 80-90% of collagen in the body consists of what type of collagen? what do fibrils aggregate into? how and where is collagen synthesized? what aa motif is characteristic of collagen? where does its strength come from? what cofactor is needed for hydroxylation? |
- fibrillar collagen (type I, II, III) - fibrils aggregate into fibers - collagen is first synthesized as collagen α chains (pro-alpha chains) by ribosomes attached to the ER - then becomes a triple-helical procollagen molecule --> removal of N-&C-terminal propeptides = collagen - Gly-X-Y - strength comes from hydroxylation modifications (lysine and hydroxylys side chains form aldehydes for x-links in adjacent molecules) - vitamin c |
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glycosaminoglycans (GAGs) and proteoglycans what are GAGs? what is their charge? |
GAGs are unbranched polysacch. chains with repeating disacch units (amino sugar + uronic acid) - usually highly negatively charged, most anionic molecules produced by animal cells |
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