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427 Cards in this Set

  • Front
  • Back
What is the specific heat of water? ***
high (meaning it retains thermal energy well)

4.19 J/g/C
What is the thermal conductivity of water? ***
good (meaning it conducts heat well)

(0.0014)
What is specific gravity? ***
the weight of a particular substance compared with the weight of an equal volume of water
What is the specific gravity of water? ***
1.0
How does specific gravity affect an object in water? ***
an object with a specific gravity
>1 will sink
<1 will float
What is the specific gravity of a human? ***
0.97
Does the human body tend to sink or float? ***
float (especially with higher fat content)

specific gravity is < 1 (0.97)
What is buoyancy? ***
a force experienced as an upward thrust on an object immersed in fluid
What is Archimedes' principle? ***
an immersed object will experience an upward thrust equal to the weight of the liquid displaced
How does water provide resistance? ***
its viscosity provides resistance to motion in water
What is the relationship between resistance and speed in water? ****
as speed increases, so does resistance

(they are directly proportional)
What is hydrostatic pressure? ***
the pressure exerted by a fluid on a body immersed therein
What does Pascal's law state? ***
- fluid exerts equal pressure on all surfaces of an immersed body at any given depth

- pressure increases as depth increases
What are some of the physiological effects of hydrotherapy (immersion)? ***
- cleansing (wound therapy)
- decreased weight bearing (aids exercise)
- strengthening (due to resistance)
- slowing of bone density loss
(when compared to doing no exercise at all; is not as effective as land-based, weight-bearing exercise in preventing bone density loss)
How does hydrotherapy affect fat loss? ***
less fat is lost in hydrotherapy (when compared to land-based exercise)
What are the physiological effects of hydrotherapy? ***
when compared to land-based exercise at the same rate of perceived exertion (RPE), there is a lesser increase in:
- heart rate
- systolic blood pressure, and
- VO2
Which is more efficient, land-based exercise, or hydrotherapy? ***
exercise on land is generally more efficient, IF the person is able to do so
What are some uses of hydrotherapy in PT? ***
- superficial heating or cooling
- pain control (RA, fibromyalgia)
- edema control (with cooler temperatures)
- wound care
- water exercise for:
----- neurological pts. (esp those at risk of falls)
----- cardiorespiratory fitness
----- pregnancy
----- asthma patients
----- older patients
In what ways is hydrotherapy used for edema control? ****
- cooler temp
- for venous or lymphatic insufficiency
- inflammation (cold)
For which patients might hydrotherapy in the form of water exercise be beneficial? ***
- neurological pts. (esp those at risk of falls)
- cardiorespiratory fitness
- pregnancy
- asthma patients
- older patients
How does water exercise help neurological patients? ***
- increases proprioceptive input
- gives weight relief
- reduces risk of falls
- allows greater movement exploration
- reduces spasticity
How does water exercise help patients with cardiological or respiratory issues? ***
allows them to exercise when they cannot tolerate land-based exercise
What is important to remember about patients with cardiological or respiratory issues during water exercise? ***
they must be monitored more closely
How does water exercise help pregnant patients? ***
- removes increased load from weight-bearing joints
- controls peripheral edema
- induces less of an increase in heart rate, blood pressure, and body temperature in comparison to land-based exercise, thus is safer for fetus

would also think more beneficial with respect to balance issues--less likely to fall due to the obvious shift of body's center of gravity
How does water exercise help asthma patients? ***
- eliminates airborne allergens
- increased humidity less likely to trigger symptoms
How does water exercise help older patients? ***
allows those who cannot tolerate land-based exercise to continue being active
What types of hydrotherapy are used in wound care? ***
- full immersion
- local immersion
- non-immersion
How is hydrotherapy used in wound care? ***
- cleansing
- hydration
- softening
- debridement
- increased circulation (especially with immersion)
What are the temperature ranges used in hydrotherapy? ***

Memorize those indicated by *
- cold (32-79F) *
- tepid (79-92F)
- neutral warm (92-96F)*
- mild warm (96-98F) *
- very hot (104-110)
What temperature range is used with hydrotherapy for inflammation? ***
cold (32-79 F)
What temperature range is used for hydrotherapeutic exercise? ***

(I guess this is general patient exercise, not those with other medical issues??)
tepid (79-92 F)
What temperature range is used for hydrotherapeutic exercise with medical patients? ***

(Those with other medical issues, such as cardio, pulmonary, etc.??)
neutral warm (92-96 F)
What temperature range is used for hydrotherapy for chronic conditions? ***
very hot (104-110F)
Convert F to C:
C = (F-32) * 5/9
Convert C to F:
F = 9/5 C + 32
What are some general contraindications/precautions for hydrotherapy? ***
- bleeding
- maceration (softening of skin around wound)
- recent skin graft
- infection in area (local immersion OK)
- impaired sensation/mentation
What are some contraindications/precautions for full immersion hydrotherapy? ***
CI
- cardiac instability
- neurological disorders
- mental disorders
- infection that may spread in water
- bowel incontinence

P
- medications
- respiratory problems (require more supervision)
- urinary incontinence
- limited strength, endurance, ROM
What are some contraindications/precautions for hot water, full immersion hydrotherapy? ***
- pregnancy
- multiple sclerosis
- poor thermal regulation
What are some potential adverse effects of hydrotherapy? ***
- hyponatremia (low sodium concentration--esp with burn patients)
- infection
- bleeding
- burns
- fainting
- aggravation of edema if temperature is warm
- chlorine (reactions to it?)
What needs to be done to the hydrotherapy tubs regularly? ***
they need to be cultured and checked regularly
What are some disadvantages of hydrotherapy? ***
- cost (money and time)
- use of large quantities of water
- limited size of tank
What does TENS stand for? ***
T - transcutaneous
E - electrical
N - nerve
S - stimulation
Describe a TENS unit. ***
- small, portable device
- battery operated (if it plugs in, it's not really TENS)

- asymmetrical, bi-phasic wave
- used for pain control
What two pain theories are used to explain the effects of TENS? ***
- gate control theory
- neurochemical basis of pain inhibition (a.k.a. Endorphin theory)
What type of wave does the TENS unit use? ***
- asymmetrical
- bi-phasic
What is the purpose of the TENS unit? ***
pain control only
What is the gate control pain theory? ***
gate (to allow pain to brain to be felt) is "opened" by:
- A-delta (lightly myelinated, small) fibers and
- C (unmyelinated, small) fibers

gate is "closed" by:
- A-beta (heavily myelinated, large) fibers
What neurochemicals, when stimulated, act to inhibit pain? ***
- enkephalins
- endorphins
What is the half-life of enkephalins? Of endorphins? ***
- 2 minutes
- 4 hours
List four modes of TENS application. ***
- conventional (high rate)
- acupuncture-like (low frequency)
- burst
- brief intense
What three parameters are common to all E-stim modalities?
- amplitude (or intensity)
- frequency (or pulse rate)
- pulse duration (or pulse width)
Parameters for conventional mode on TENS unit ***
amplitude/intensity - sub-motor, tingling (just above threshold; what patient finds comfortable)
frequency/pulse rate - 100-150 cps (high)
pulse duration/pulse width - 50-80 microsec (low)
time - as needed (up to 24 hours, usually in 30-min intervals)

rapid, narrow pulses = tingling
Uses for conventional mode on TENS unit ***
- both acute and chronic pain, but
- primarily acute

(the low pulse duration/pulse width and high frequency/pulse rate are more comfortable, especially in the acute phase, as they produce a tingle, not a prolonged contraction)
Parameters for low-frequency mode on TENS unit ***
amplitude/intensity - local motor contraction (twitch)
frequency/pulse rate - 2-10 cps (low)
pulse duration/pulse width - 200-300 microsec (high)
time - approximately 30 minutes

longer-lasting, less frequent pulses = contraction (twitch)
Uses for low-frequency mode on TENS unit ***
- both acute and chronic pain, but
- primarily chronic

(the high pulse duration/pulse width and low frequency/pulse rate produce a more prolonged contraction, which is better tolerated in the subacute/chronic state)
Parameters for burst mode on TENS unit ***
amplitude/intensity - local motor contraction (twitch)
frequency/pulse rate - 1-10 bps (low)
pulse duration/pulse width - 200-300 microsec (high)
time - approximately 30 minutes

similar to low-frequency, but numerous bursts within each wide pulse = contraction (twitch)
Uses for burst mode on TENS unit ***
- both acute and chronic pain, but
- primarily chronic

(the high pulse duration/pulse width and low frequency/pulse rate with bursts within each pulse, produce a more prolonged contraction, which is better tolerated in the subacute/chronic state)
Parameters for brief intense mode on TENS unit ***
amplitude/intensity - motor response (vermicular)
frequency/pulse rate - 110 pps (high)
pulse duration/pulse width - 250 microsec (high)
time - approximately 15 minutes

(longer, more frequent pulses = vermicular muscle movement (wormlike, more than twitching)
Uses for brief intense mode on TENS unit ***
- intense acute pain

(the high pulse duration/pulse width and high frequency/pulse rate produce a vermicular muscle movement, tolerated in the acute state; can fatigue muscle and break up spasm)
How is modulation used with TENS? ***
changes in
- amplitude
- pulse width/pulse duration, or
- frequency/pulse rate

either individually or in combination serve to decrease patient accommodation to treatment
How are TENS electrodes placed? ***
- on point of pain
- on referring nerve root
- on acupuncture point proximal or distal to pain
- transarthral (across/through the joint)
- bilateral
- in a crossed-pattern technique (need 4 electrodes in this case)
What is the isoelectric line?
the baseline above and below which the waveform travels (in a biphasic wave)
What is an asymmetrical, biphasic wave? ***
A wave that is not symmetrical above and below the isoelectric line
Why is frequency/pulse rate important in TENS setup?
because different frequency settings target different nerve groups and the setting will determine if the "Gate Theory" or "Endorphin Theory" of TENS will be in effect
Why is pulse duration/pulse width important in TENS setup?
in general, the higher the pulse width, the more "aggressive" the stimulation feels (and less comfortable)

eventually, if the pulse width is high enough, it will usually elicit a muscle contraction, which may not be the desired result

if the pulse width is too low, however, the patient may not perceive the stimulation
Simply put, amplitude in a TENS unit is
what you feel when you "turn the unit up"

it's what causes the "buzzing" sensation of the TENS to go higher or lower
Which TENS mode(s) work on the Gate Control theory?
conventional
(and to a degree, brief intense)

high frequency/pulse rate electrical activity is believed to block the pain by stimulating A-beta (large, heavily myelinated) fibers
Which TENS mode(s) work on the Endorphin theory?
low frequency
burst
(and to a degree, brief intense)

low frequency or short bursts of mild electrical activity is believed to cause the body to release its own pain erasers (beta endorphins)
TENS is used only for ***
pain control
Which fibers are believed to open pain gates?
A-delta (small, myelinated, acute) and
C (small, unmyelinated, chronic) fibers
Which fibers are believed to close pain gates?
A-beta (large, heavily myelinated)
How do the Gate Control and Endorphin theories affect pain with the application of TENS?
- Gate Control tends to only work for the duration of the application; that is, there is little carry-over effect (thus treatment time for conventional is up to 24 hours)

- Endorphin theory modes (low frequency and burst) tend to have a carry-over effect due to the half-lives of the endorphins released
Another name for low-frequency TENS?
acupuncture TENS
Brief intense mode of TENS may achieve rapid relief of intense acute pain, however:
some patients may find the stimulation to be too much and may not be able to tolerate it for the treatment time required to achieve the desired results
Through which pain control theory is brief intense TENS thought to work?
through both
- Gate Control and
- Endorphin theories

because the
pulse duration/pulse width is high - Endorphin, and
frequency/pulse rate is high - Gate Control
What tends to happen to patients that are mobile during TENS application?
they tend to lose the electrodes
What is the minimum number of electrodes needed for TENS application?
2

if you can treat with 2, do so
(she said this in lab, dunno why)
Contraindications for ES
- cancer
- phlebitis, thrombus, thrombophlebitis
- pacemaker, other internal electrical device
- arrhythmia
- over carotid sinus
- transcerebral
- transthoracic
- over fresh fracture
- hemorrhage
How far apart should TENS electrodes be placed?
- at least one inch
- ideally, the width of the electrode
When a twitch is produced by a TENS treatment, where does it appear?
may be
- under the electrodes
- between the electrodes
How does pulse duration/pulse width of TENS relate to comfort?
imagine it like a needle

narrower needle goes into arm more comfortably
wider needle hurts more
Electricity is a form of _______. ***
energy
Electric current is ***
the flow of charged particles
What charged particles flow in metal? ***
electrons
What charged particles flow in human tissue? ***
ions
What is a charge? ***
an excess or deficiency of electrons
What is the charge of an atom? ***
neutral
What is the charge of an ion? ***
either
positive - cation (electrons lost)
or
negative - anion (electrons gained)
What is an ion? ***
a particle with a charge (either positive or negative)
What is voltage? ***
the potential difference between two points in an electrical field

the force that causes charged particles to move
Electromotive force is measured in ______. ***
volts
What is current? ***
flow of charged particles

represented as I
How is current measured? ***
amperes (amps)
One ampere = ***
6 trillion electrons/sec
One coulomb =
1 ampere/sec

6 trillion electrons/sec
What is power (P)? ***
voltage * current

P=VI

measured in watts (W)
What is resistance? ***
opposition to movement by charged particles
How is resistance measured? ***
ohms
Resistance is directly proportional to: ***
length of conductor
Resistance is inversely proportional to: ***
cross-sectional area of conductor
What is Ohm's Law? ***
flow of current is directly proportional to EMF (current) and inversely proportional to resistance of circuit

V = IR
What is conductance? ***
ease of movement of charged particles (mhos) or (siemens)
What is a conductor? ***
a material through which electricity flows easily

(e.g., copper, water, nerve, muscle, blood)
What is an insulator? ***
a material through which electricity does not flow easily

(e.g., rubber, glass, wood, fat, bone, skin)
What is the best conductor in the body? Followed by....? ***
best conductor in body is nerves

then muscle, then anything with water (e.g., blood)
What is A.C.? ***
alternating current

bidirectional flow of charged particles
What is D.C.? ***
direct current

unidirectional flow of charged particles
Describe a DC and an AC waveform. ***
DC - unidirectional flow
AC - bidirectional flow
What is the conventional theory of current flow? ***
current flows from positive to negative pole

(surplus to shortage)
What is the electron theory of current flow? ***
current flows from negative to positive pole

(negative to positive)
What types of modes are available for E-stim? ***
- continuous
- pulsed (mono/bi/polyphasic)
- burst
- interrupted
What is burst mode? ***
a finite series of pulses delivered in a package or "envelope" as a single pulse at a defined frequency
What is interrupted mode? ***
current flows for at least one second and ceases to flow for at least one second

(usually with a hand-held electrode where one manually opens and closes the circuit)
For what is interrupted mode used? ***
- trigger points
- acupuncture points
What shapes may a waveform take? ***
may take any of the following shapes and with each may also be symmetrical or asymmetrical

- rectangular
- square
- spiked/twin spiked
- sine
What pulse types may the waveform take? ***
- monophasic (pulse deviates in one direction--DC)
- biphasic (pulse is bidirectional--AC)
- polyphasic (pulse has more than 2 phases--Russian, Interferential)
How does the TENS unit convert the DC charge from the 9V battery to AC (biphasic)?
via a transducer in the unit
What are the characteristics of a balanced biphasic wave? ***
- it has the same amount of charge both above and below the isoelectric line

- the positive and negative phases do not have to have the same shape/waveform, just the same amplitude
(e.g., may be +5 mA rectangular pulse above the isoelectric line and a -5 mA spiked pulse below the isoelectric line)
Can a biphasic wave be balanced without being symmetrical? ***
Yes

the waveforms above and below the line may differ from each other (asymmetrical) but as long as the amplitude is equal they are balanced
How is DC frequency measured? ***
in pulses per second (pps)
How is AC frequency measured? ***
in cycles per second (cps)

a.k.a. Hz
Pulse width is also known as: ***
pulse duration

(which is more correct, as we are discussing time)
Waveform of a TENS unit? ***
biphasic, asymmetrical
What are the three main parameters to remember with E-stim? ***
- Phase/pulse duration (width) - beginning to end of phase or pulse, usually measured in microseconds or milliseconds

- Amplitude - magnitude of current or voltage, measured in amps or volts

- Frequency (rate) - pps or cps

(Also phase or pulse charge - the charge within each phase or pulse)
What is the intrapulse (a.k.a. interphase) interval? ***
the time between two successive components of a pulse when no electrical activity occurs
What is the interpulse interval? ***
the time between pulses when no electrical activity occurs
What is rise time? ***
the time from baseline (0) to peak amplitude
What is decay time? ***
the time from peak amplitude back to baseline (0)
What is ramp time? ***
the time it takes to reach peak amplitude of a pulse train
What is total current? ***
current delivered to tissue/sec

= phase charge * number of phases/sec
How can one increase the total current delivered? ***
increase the
- intensity (amplitude),
- frequency (rate) and/or
- pulse duration (pulse width)
What is considered
- low volt?
- high volt? ***
- less than 100 volts

- 300 - 500 volts
What is considered
- low frequency?
- medium frequency?
- high frequency? ***
- up to 1,000 pps/cps/Hz
- 1,000 - 10,000 pps/cps/Hz
- > 10,000 pps/cps/Hz
How high does the frequency go in a TENS unit? ***
up to roughly 120 pps, which is considered "high" even though that rate places it in the "low frequency" category
What types of electrodes are used with E-stim? ***
- surface electrodes
----metal plate (need wet sponges)
----carbon impregnated
----self-adhering, reusable

- hand-held (wand; use gauze)

- invasive (implanted)
What are the considerations for electrode use? ***
- size should fit treatment area

- current density is inversely proportionate to electrode size (smaller electrode concentrates the energy)

- distance between electrodes affects penetration depth of energy (the further apart the electrodes are, the deeper the energy penetrates)
What are the lead types used with E-stim electrodes? ***
- banana (thicker than telephone/pin)
- telephone (pin)
- McIntosh (screw down)
- alligator (can wrap in foil and gauze and use in open wounds)
How can electrodes be placed to get deeper tissue penetration?
place them farther apart
Why does a smaller electrode deliver a higher current density?

How can the therapist use this to their advantage?
a smaller electrode is still conducting the same amount of current, therefore it will be concentrated in a smaller space

the therapist can place the smaller electrode on the target area to deliver more concentrated energy to that point
How does polarity affect treatment? ***

(DC only, as AC alternates being anode and cathode)
anode - positive pole
- repels positive ions
- sclerotic (toughening and desensitizing)
- analgesic effects

cathode - negative pole
- repels negative ions
- sclerolytic (softening)
- stimulating effect
What three types of electrode configurations can be used? ***
- monopolar - 1 active electrode (smaller) on the target, and 1 dispersive electrode

- bipolar - 2 equal-sized electrodes (spaced for needed depth)

- quadpolar - four same-size electrodes
What are the basic uses of ES? ***
- pain modulation (gate control/endogenous opiates)
- muscle relaxation (spasm reduction)
- muscle re-education (innervated muscle)
- stimulation of denervated muscle
- edema reduction
- wound healing
- peripheral circulation
- iontophoresis
How are endogenous opiates (Endorphin theory) produced by ES? ***
- low rate (1-5 pps)

- muscle contraction (high pulse duration/pulse width)
Breakdown of E-stim:
- AC variants
- DC variants ***
NM - neuromuscular
F - functional
M - muscular
Precautions for ES ***
- cardiac disease
- CVA
- over pregnant uterus (ex. possibly 3rd trimester/labor)
- decreased sensation/mentation
- obesity
- extreme osteoporosis
- skin irritation, open wound
- superficial metal
When considering in ES:
- pulse duration/pulse width
- amplitude
- frequency/rate
what is more comfortable to the patient?
generally speaking
- shorter pulse duration/width is more comfortable
- amplitude varies by patient tolerance
- higher frequency/rate is more comfortable
What is interference? ***
the superposition of 2 or more waves, resulting in a new wave pattern
What is IFC? ***
- use of 2 sinusoidal current sources of medium frequency (1,000-10,000 Hz), created by two separate generators

- the two currents are intersected at 90 degrees

- the results create an interference wave
What is constructive interference? ***
- two superimposed waves of the same frequency (exactly aligned)

- the effects add together in the interference wave

- final wave has twice the amplitude
What is destructive interference? ***
- two superimposed waves of different frequencies (out of sync)

- the effects detract from each other in the interference wave
Full field or amplitude summation IFC characteristics ***
- frequencies of both currents are equal
- interference is "constructive" or "summative"
- results in vector of twice the original amplitude
- stimulates both at the surface and within tissue
- as in above picture, third wave may be static or dynamic (scan on)
- with scan on the amplitude is modulated so patient feels it in different places (sweep is frequency modulation)
Frequency difference IFC characteristics ***
- the frequency of the two currents differs
- results in a clover-leaf vector (or beat frequency)
- produces polyphasic pulses
- interference is destructive
- primarily stimulation within tissue (deep)
Contrast frequency difference IFC with scan off and scan on
With scan off and scan on
What is the carrier frequency? Which is it in the picture? ***
it is the base frequency of the unit before modification (the slower/lower of the two currents when they differ)

In the picture, the blue waveform is the carrier frequency
Advantages of IFC ***
- medium frequency decreases skin impedance more effectively
- greater intensity can be used to drive current into underlying tissue, since less used to overcome skin impedance
- more comfortable

- in general, the higher the frequency, the more comfortable the sensation
What are the indications for IFC? ***
- pain
- inflammation
- muscle spasm
- edema
What are the contraindications for IFC? ***
same as for other ES:
- cancer
- phlebitis, thrombus, thrombophlebitis
- pacemaker, other internal electrical device
- arrhythmia
- over carotid sinus
- transcerebral
- transthoracic
- over fresh fracture
- hemorrhage
How many electrodes are required for true IFC? ***
four
Which tissue is more excitable, nerve or muscle? ***
nerve
Which tissue has higher capacitance, nerve or muscle? ***
muscle
What is an action potential? ***
- sequence of depolarization and repolarization of nerve (or muscle) in response to stimuli

- "the basic unit of nerve communciation" (Cameron)

- also occurs along muscle (Michlovitz)
What happens when nerve or muscle cell depolarizes? ***
- the cell at rest has a negative charge and there is a high concentration of sodium outside its membrane

- depolarization opens sodium channel, sodium rushes in and changes polarization of (depolarizes) the cell
What is the resting potential of the cell membrane? ***
inside cell is -60 to -90 mV

(average used -70 mV)
How does depolarization work? ***
- Na+ channels open rapidly
- K+ channels open slowly

- sodium rushes in and causes depolarization (Na+/K+ pump)
How does the depolarization affect polarity of the cell? ***
- reverse polarization

- influx of Na+ reverses membrane polarity

- inside becomes more positive (goes from -70 to +30 mV)
What brings about repolarization of the cell? ***
- once cell membrane potential reaches +30 mV, it becomes impermeable to Na+
- K+ channels rapidly open
- becomes more permeable to K+, allowing it to leave the cell and remove the positive charge inside
- membrane polarization returns to its resting state of approximately -70 mV
What does hyperpolarization initiate? ***
the refractory period (where the cell will temporarily not respond to additional stimulation)
Will a muscle cell membrane allow depolarization in response to ES if the nerve is not intact? ***
it may, if a pulse of long duration and adequate amplitude is applied
Contrast natural physiologcial contraction (NPC) of muscle with an ES contraction (ESC) of muscle. ***
NPC
- AP occurs only in one direction
- small-diameter, slow-twitch fibers activated first; then large-diameter, fast twitch fibers recruited
- small-diameter, slow-twitch fibers are more fatigue resistant
- less fatiguing to patient
- contractions are smoother

ESC
- AP may propagate in both directions
- large-diameter, fast-twitch fibers activated first; then small-diameter, slow-twitch fibers are recruited later
- large-diameter fibers fatigue more quickly
- more fatiguing to patient
- contractions are jerkier
ES can be used to facilitate action potential in:
- sensory nerves
- motor nerves
- denervated muscles

but require different amplitudes and durations
What is the relationship between strength and duration of ES application? ***
- they are inversely proportional

- the stronger the current, the shorter duration needed
What is rheobase? ***
- the intensity of amplitude, with long duration stimulus, required to produce an action potential

- essentially, "amplitude"
What is chronaxie? ***
- the duration of ES application required to stimulate tissue at 2X rheobase (amplitude)

- essentially, "duration"
Indications for NMES? ***
- decreased strength and endurance
- decreased ROM
- post injury or surgery
- muscle spasms
- edema reduction
- orthotic substitution and FES
- rehab post nerve injury (dennervated muscle) (EMS)
How is NMES used to treat decreased strength and endurance? ***
in conjunction with active exercise
How is NMES used to treat decreased ROM? ***
- to stimulate muscle groups that can increase ROM

(e.g., with elbow flexion contracture, stimulate the triceps; or, alternately, stimulate the agonist, then the antagonist)
How is NMES used post injury or surgery? ***
- assist in initiating movement in a muscle or muscle group
How is NMES used to treat muscle spasms? ***
- the involuntary contractions may fatigue the muscle and allow it to rest
- break the pain-spasm-pain cycle
How is NMES used for edema reduction? ***
- contractions can help pump fluid from the area
- if DC is used, place the negative electrode at the area to repel negatively charged proteins
How is NMES used for orthotic substitution and FES? ***
- ambulation assistance--(e.g., attachment with heel switch to counter foot drop)
- shoulder rehab post shoulder subluxation
Rehab post nerve injury (dennervated muscle) is more specifically referred to as: ***
EMS
What factors need to be considered when using NMES for rehabilitation? ***
- how to apply
- placement of electrodes
- parameters to use
- diagnosis and goals
- patient age, tolerance, muscle size
- equipment available
What three variations of electrode setup can be used with NMES? ***
- monopolar
- bipolar
- quadrapolar
What should be considered in electrode placement with NMES? ***
- try to put one electrode on a motor point
- place electrodes parallel to direction of muscle fibers
What is a motor point? ***
- where the nerve enters the muscle
- where electrical stimulus produces greatest contraction with least amount of stimulus
(see pp. 25-35)
What should be considered in electrode placement with NMES? ***
- try to put one electrode on a motor point
- place electrodes parallel to direction of muscle fibers
What is a motor point? ***
- where the nerve enters the muscle
- where electrical stimulus produces greatest contraction with least amount of stimulus
(see pp. 25-35)
NMES monopolar electrode setup ***
NMES bipolar electrode setup ***
NMES quadrapolar electrode setup ***
Parameters for Russian ***
- middle frequency
- AC
Frequency for NMES
- twitch
- vermicular
- tetanic contraction ***
- 5 pps
- between 5 and 35 pps
- over 35 pps
Pulse duration/width for NMES ***
- generally high (200-400 microsec)

- need to consider comfort
Duty cycle for NMES ***
on:off with "on" phase of about 6-10 sec
- early rehab 1:5
- progress to 1:3
- for spasm or edema 1:1 (2-5 sec)

- ramp up/down
Amplitude for NMES ***
enough to get contraction, but not cause pain
Things to consider for contraction of denervated muscle ***
- muscle cannot contract physiologically
- does not respond to AC
- may respond to DC with a long-duration pulse (usually with a manual switch)
- presently, is not the recommended treatment, although it was in the past
What happens to an injured nerve during the first 14 days or so? ***
reaction of degeneration
- anterograde/Wallerian degeneration - distal to injury site
- retrograde degeneration - proximal to injury site
How fast can nerve tissue regenerate? ***
IF the nerve regenerates, it heals
- approx. 1 mm/day, or
- 1 inch/month
What should the therapist remember to do before changing ES treatment parameters? ***
TURN THE INTENSITY DOWN!
In what forms may AC be delivered? DC? ***
both AC and DC may be delivered either continuously or pulsed
At what pulse duration/pulse width is DC considered to be continuous? ***
if the pulse is >= 1 second

< 1 second is pulsed
Which is more comfortable to the patient, AC or DC? ***
DC is less comfortable than AC

it stings a bit
By what mechanisms has in vivo/vitro research suggested ES (specifically DC) can assist wound healing? ***
- alters cell membrane function
- increases protein synthesis
- has antibacterial effects
- promotes blood flow
- improves tissue oxygenation
- induces galvanotaxis
What is galvanotaxis? ***
occurs when charged cells are attracted to an electric field

(e.g., negatively charged ions are attracted to a positive electrode)
Describe the electrical potential difference within the skin. ***
the epidermis is negatively charged relative to the dermis

------ Epidermis
+++ Dermis
What happens to the electrical potential difference across the skin when there is a soft tissue injury? ***
the wound and adjacent epidermis become positive relative to the uninjured tissue

this electrical potential difference steadily declines over time, returning to normal only after the wound closes

ES may accelerate tissue healing by replicating or enhancing this process
Current of injury
- the transcutaneous potential of intact skin can be measured at 40-80 mV, but as soon as a full-thickness incision is made, this disappears so that a voltage gradient forms between the wound and surrounding intact skin (Jaffe & Vanabe, 1984)

- a microcurrent will then flow from the area of higher potential (the intact skin) into the wound so that a current of injury is generated

- the voltage peaks immediately after injury and gradually decreases as the wound heals (McGinnis & Vanable, 1986), leading to the concept that current flows may be defective in chronic wounds, and that applying electrical currents to wounds may stimulate healing (Kloth, 1995)
How can ES (specifically DC) help with wound healing? ***
- if barrier is broken, a flow of positive polarity occurs within the wound

- placing a negative charge (cathode) in the wound also attracts positive ions and is thought to trigger wound healing.

- exogenous ES may mimic body’s own bioelectric currents, facilitating or reinitiating (in a chronic wound) the wound healing process
At what stage of healing should negative polarity be used? ***
negative polarity (cathode) should be used in the acute stage of healing (3-7 days)

(Kloth)
When should the therapist switch to treatment with positive polarity in wound healing? ***
change to positive polarity (anode) in proliferative phase to facilitate epithelial cell migration
When would the therapist continue with treatment with negative polarity after the acute stage? ***
continue with negative polarity (cathode) if infection and/or inflammation present
What treatment should be used if tissue necrosis without inflammation is noted? ***
use positive polarity (anode)
What do some other wound treatment protocols suggest? ***
alternating polarities every few days
Protocol for DC wound ES ***
- place one electrode in wound
(saline-soaked gauze, aluminum foil, attached to alligator clip)

- another option is to place the electrodes around (outside) the wound with the target electrode proximal

- place the larger, dispersive electrode at convenient site
(Prentice suggests anode should be placed proximally, while Michlovitz, Behrens suggest placement away from the wound where skin is intact)

- some argument as to whether better to place proximal or distal
(go with proximal)
Cathode

Anode
***
- negative, usually black

- positive, usually red
What physiological effects tend to occur under the cathode? ***
- sodium combines with water to form sodium hydroxide
- alkaline reaction
- can cause softening (sclerolysis) of tissues

- stimulating effect on nerves, muscles
- bacteriostatic or bacteriocidal effects
- attracts fibroblasts (evolve into collagen), mast cells, platelets
What physiological effects tend to occur under the anode? ***
- chloride combines with water to form hydrochloric acid
- acidic reaction
- can cause hardening (sclerosis) of tissues, especially skin.

- analgesic effect
- attract macrophages
What is the other use of DC ES? ***
- can be used to treat edema

- place cathode at site of swelling to repel negatively charged proteins
What is iontophoresis? ***
introduction of ionic substances into the body for therapeutic purposes by use of DC
Why is iontophoresis used? ***
most common uses:
- reduction of inflammation (most often)
- pain relief

- alternative to injection
- less chance of systemic side effect
What forms of medication are used in iontophoresis? ***
- aqueous solutions
- ointments
- creams
What are the two most common medications used in iontophoresis, and what are their polarities? ***
- Decadron (dexamethasone) - negative (-)

- Lidocaine - positive (+)
How deeply do medications delivered by iontophoresis typically penetrate? ***
3-20 mm
What are some other uses for iontophoresis? ***
- calcium deposits- acetic acid (-)
- scar tissue- sodium chloride (-)
- athlete’s foot- copper sulphate (+)
- plantar warts- salicylate (-)


(Need to know other indications; but do not need to know the polarity needed in treatment for these.)
Parameters for iontophoresis delivery ***
- current type is most commonly continuous DC

- dosage is written as mA.min (mA minutes, NOT mA per minute!!)

- current (mAmp)
- time (minutes)
What are the typical dosages for
- phoresor unit?
- patches? ***
Recommended dosage with a
- phoresor unit is 40 mA.min
- patches may be higher: 80 mA.min
How is the 40 mA-min dosage administered with the phoresor unit? ****
time X mA

- if amplitude is set at 4 mA, it would take 10 min. to complete tx.

- if amplitude is set at 2 mA, it would take 20 min. to complete tx.

(It all depends upon what level of mA the patient can tolerate.)
Electrode configuration for iontophoresis ***
- active electrode over pathology
- indifferent is proximal or distal, but nearby

- medication goes under active electrode

- meds with a negative charge go under cathode.
- meds with a positive charge go under anode

(Thus opposites repel and medication is driven into skin.)
Which electrode in DC/iontophoresis tends to be a bit more irritating? ***
the negative electrode (cathode)
What can be done to reduce skin irritation with DC/iontophoresis? ***
if skin irritation occurs, increase size of negative electrode, regardless of which is active

(because of alkaline reaction)
What are the contraindications and precautions for iontophoresis? ***
besides
- allergy to medication
- use with other modalities

the same as other ES
CONTRAINDICATIONS
- cancer
- phlebitis, thrombus, thrombophlebitis
- pacemaker, other internal electrical device
- arrhythmia
- over carotid sinus
- transcerebral
- transthoracic
- over fresh fracture
- hemorrhage

PRECAUTIONS
- cardiac disease
- CVA
- over pregnant uterus (ex. possibly 3rd trimester/labor)
- decreased sensation/mentation
- obesity
- extreme osteoporosis
- skin irritation, open wound
- superficial metal
An electrical current is:
a flow of charged particles (electrons or ions)
The effects of electrical currents include:
- nerve depolarization
- muscle depolarization
- ionic effects
Most uses of electrical stimulation are based on its ability to depolarize nerves to produce:
action potentials
Once an action potential is created by an electrical current, the body responds to it the same way:
as it does to an action potential generated physiologically
An electrically stimulated action potential can affect both:
- sensory nerves, producing a pleasant or painful sensation, or

- motor nerves, producing a muscle contraction
Sensations produced by electrically stimulated action potentials in sensory nerves can:
control pain
The muscle contractions produced by electrically stimulated action potentials in motor nerves can:
- strengthen muscles,
- increase muscle endurance,
- improve function,
- assist with joint positioning,
- decrease spasticity,
- increase circulation,
- control pain
- reduce edema due to poor circulation or lack of use
The ionic effects of electrical currents can be used to:
- facilitate tissue healing
- control the formation of inflammation-related edema
- promote transdermal drug penetration
What parameters must be considered for application of electrical stimulation?
- electrode placement
- waveform
- polarity
- current amplitude
- pulse duration
- pulse frequency
- on:off times
- ramp time
- treatment time
Another term for low-rate TENS
acupuncture-like TENS
Acupuncture-like or low-rate TENS is used for what type of pain?
acute or chronic, but mainly chronic


PD/PW = 200 – 300 microsec. (HIGH)
A = local motor contraction
F/R = 2-10 cps (LOW)
Time = approx. 30 min.

wide PD/PW is less comfortable

so this is continuous, unlike burst mode, which uses the same PD/PW and A, but F/R of 1-10 bps
The anode is the:
positive electrode
Burst mode TENS is used for what type of pain?
acute or chronic, but mainly chronic

PD/PW = 200 – 300 microsec. (HIGH)
A = local motor contraction
F/R = 1-10 bps (LOW)
Time = approx. 30 min.

wide PD/PW is less comfortable

so this is burst, unlike low-rate or acupuncture-like mode, which uses the same PD/PW and A, but F/R of 2-10 cps (thus continuous)
What is another name for conventional TENS?
high-rate TENS
Conventional or high-rate TENS is used for what type of pain?
acute and chronic, but primarily acute

PD/PW = 50 - 80 microsec (LOW)
A = sub-motor, tingling
F/R = 100 - 150 cps (HIGH)
Time = as needed up to 24 hrs.

narrower PD/PW is more comfortable for acute pain
The cathode is:
the negative electrode
Charge is:
one of the basic properties of matter (which is either neutral, negative, or positive)

it is noted as Q and measured in Coulombs (C)
Charge is equal to:
current X time

Q = It
What is current density? How can it be altered?
the amount of current delivered per unit area

a larger electrode reduces current density, a smaller electrode increases it
What is electrical current?
the movement or flow of charged particles though a conductor in response to an applied electrical field

noted as I and measured in amperes (A)
What is electrical muscle stimulation (EMS)?
application of an electrical current directly to muscle to produce a muscle contraction
What is functional electrical stimulation (FES)?
application of an electrical current to produce muscle contractions that are applied during a functional activity

(e.g., electrical stimulation of dorsiflexion in a patient with foot drop during the swing phase of gait)
What is galvanotaxis?
the attraction of cells to an electrical charge

specific cells, including neutrophils, macrophages, lymphocytes, and fibroblasts can be attracted to an injured healing area by an electrical charge because the cells themselves carry a charge
What is the gate control theory?
a theory of pain control and modulation that states pain is modulated at the spinal cord level by inhibitory effects of nonnoxious afferent input
What is impedance?
the total frequency-dependent opposition to current flow

noted by Z and measured in Ohms

for biological systems, impedance describes the ratio of voltage to current more accurately than resistance because it includes the effects of capacitance and resistance
What is iontophoresis?
the transcutaneous delivery of ions into the body for therapeutic purpose using an electrical current
What is a motor point?
the place in a muscle where electrical stimulation will produce the greatest contraction with the least amount of electricity

generally located over the middle of the muscle belly
What is neuromuscular electrical stimulation (NMES)?
application of an electrical current to motor nerves to produce contractions of the muscles they innervate
What is Ohm's law?
a mathematical expression of how voltage, current, and resistance relate where voltage equals current multiplied by resistance

V = IR
What is the overload principle?
a principle of strengthening muscle that states the greater the load placed on a muscle and the higher force contraction it produces, the more strength that muscle will gain
What is phase?
in pulsed current, the period from when current starts to flow in one direction to when it stops flowing or starts to flow in the other direction

a biphasic pulsed current is made up of two phases;
- the first phase begins when current starts to flow in one direction and ends when the current starts to flow in the other direction, which is also the beginning of the second phase
- the second phase ends when current stops flowing.
What is polarity?
the charge of an electrode that will be
- positive (the anode) or
- negative (the cathode)

with a direct or monophasic pulsed current and constantly changing with an alternating or biphasic pulsed current
What is pulse?
in pulsed current, the period when current is flowing in any direction
What is resistance?
a material's opposition to the flow of electrical current

noted as R and measured in Ohms
What is TENS?
transcutaneous electrical nerve stimulation

application of electrical current through the skin to modulate pain
What is voltage?
the force or pressure of electricity

the difference in electrical energy between two points that produces the electrical force capable of moving charged particles through a conductor between those two points

voltage is noted as V and is measured in volts (V); also called potential difference
Voltage is also known as:
potential difference
What is alternating current?
a continuous bidirectional flow of charged particles

AC has equal ion flow in each direction, and thus no pulse charge remains in the tissues

most commonly, AC is delivered as a sine wave

with AC, when the frequency increases, the cycle duration decreases and when the frequency decreases, the cycle duration increases
What is medium frequency AC?
an AC with a frequency between 1,000 and 10,000 Hz (1-10 kHz)

most medium frequency currents available on clinical units have a frequency of 2500 to 5000 Hz

medium frequency AC is rarely used alone therapeutically but two medium frequency ACs of different frequency may be applied together to produce an interferential current
What is continuous current?
a continuous flow of charged particles without interruptions or breaks

a continuous current that goes in one direction only is known as a direct current (DC)

a continuous current that goes back and forth in two directions is known as an alternating current (AC)
What is a direct current (DC)?
a continuous unidirectional flow of charged particles

it is used for
- iontophoresis
- stimulating contraction of denervated muscle
- occasionally to facilitate wound healing
What is interferential current?
interferential current is the waveform produced by the interference of two medium frequency (1,000 to 10,000 Hz) sinusoidal ACs of slightly different frequencies

these two waveforms are delivered through two sets of electrodes through separate channels in the same stimulator

the electrodes are configured on the skin so that the two ACs intersect

when the currents intersect, they interfere, producing a higher amplitude when both currents are in the same phase and a lower amplitude when the two currents are in opposite phases

this produces envelopes of pulses known as beats

the beat frequency is equal to the difference between the frequencies of the two original ACs

the frequency of the original AC is called the carrier frequency

(for example, when a carrier frequency of 5000 Hz interferes with a current with a frequency of 5100 Hz, a beat frequency of 100 Hz will be produced in the tissue)

typically, electrical stimulation units that produce interferential stimulation allow the clinician to set the beat frequency and some also allow the clinician to select the carrier frequency
Why is interferential current thought to be more comfortable?
it is proposed that interferential current is more comfortable than other waveforms because it allows a low-amplitude current to be delivered through the skin, where most discomfort is produced, while delivering a higher current amplitude to deeper tissues

interferential current also delivers more total current than pulsed waveforms and may stimulate a larger area than other waveforms

however, although a number of studies have found that interferential current can decrease pain associated with inflammation or ischemia in animals and humans, the few studies where biphasic pulsed currents (as typically used for TENS) have been compared with interferential current have not found one to be more effective than the other, although one study found that the effects of interferential current lasted longer
What is premodulated current?
an alternating current with a medium frequency and sequentially increasing and decreasing current amplitude, produced with a single circuit and only two electrodes

this current has the same form as an interferential current that is produced by the interference of two medium-frequency sinusoidal ACs that requires four electrodes

the advantages of interferential current, including a lower current amplitude being delivered to the skin and a larger area of stimulation, are not reproduced by premodulated current

("Fake" IFC)
What is pulsed current?
an interrupted flow of charged particles where the current flows in a series of pulses separated by periods when no current flows

the current may flow in one direction only or flow back and forth during each pulse

a series of pulses where the charged particles move only in one direction is known as a monophasic pulsed current

a series of pulses where the charged particles move in one direction and then in the opposite direction is known as a biphasic pulsed current
What is monophasic pulsed current?
monophasic pulsed currents may be used for any clinical application of electrical stimulation but are most commonly used in tissue healing and acute edema management applications

the most commonly encountered monophasic pulsed current is HVPC, (also known as pulsed galvanic current)

this waveform is made up of pulses composed of-a pair of short, exponentially decaying phases, both in the same direction
What is biphasic pulsed current?
a biphasic pulsed current may be symmetrical or asymmetrical, and if asymmetrical, may be balanced or unbalanced

with a symmetrical or a balanced asymmetrical biphasic pulsed current the charge of the phases are equal in amount and opposite in polarity, resulting in a net charge of zero

with an unbalanced asymmetrical biphasic current the charge of the phases are not equal, and there is a net charge

in general, the biphasic pulsed current waveforms available are balanced

although there is often little clinical difference in the effects of symmetrical and asymmetrical pulsed currents, one study found that subjects found asymmetrical biphasic waveforms to be more comfortable when used to produce contractions of smaller muscle groups, such as the wrist flexors or extensors, and symmetrical biphasic waveforms to be comfortable when used to produce contractions of larger muscle groups, such as the quadriceps
What is Russian protocol?
Russian protocol is a waveform with specific parameters intended for quadriceps muscle strengthening

this protocol was developed by Kots who was involved in the training of Russian Olympic athletes

it uses a medium frequency AC with a frequency of 2500 Hz delivered in 50 bursts/second

each burst is 10 ms long and is separated from the next burst by a 10 ms interburst interval

this type of current is also known as medium-frequency burst AC (MFburstAC), and when this term is used, the frequency of the medium-frequency current or the bursts may be different from the original protocol
What is frequency?
the number of cycles or pulses per second

frequency is measured in Hertz (Hz) for cycles or pulses per second (pps) for pulses
What is the interphase interval (intrapulse interval)?
the time between phases of a pulse
What is the interpulse interval?
the time between pulses
What is on:off time?
on time is the time during which a train of pulses occurs

off time is the time between trains of pulses when no current flows

on and off times are usually only used when electrical stimulation is used to produce muscle contractions

during the on time, the muscle contracts, and during the off time it relaxes

the off times are needed to reduce muscle fatigue during the stimulation session

the sequential on and off times also attempt to mimic the voluntary contract and relax phases of normal physiological exercise

the relationship of the on and off time is often expressed as a ratio, for example, if a muscle is stimulated for 10 seconds and then allowed to relax for 50 seconds, this may be written as a 10:50 second on:off time or a 1:5 on:off ratio
What is phase duration?
the duration of one phase of a pulse

phase duration is generally expressed in microseconds (μs = 10 -6 seconds) or milliseconds (ms = 10 -3 seconds)
What is pulse duration?
the time from the beginning of the first phase of a pulse to the end of the last phase of a pulse

pulse duration is generally expressed in microseconds (μs= 10 -6' seconds)
What is ramp up/ramp down time?
the ramp up time is the time it takes for the current amplitude to increase from zero, at the end of the off time, to its maximum amplitude during the on time

a current ramps up by having the amplitude of first few pulses of the on time gradually be sequentially higher than the amplitude of the previous pulse

the ramp down time is the time it takes for the current amplitude to decrease from its maximum amplitude during the on time back to zero
Why is ramp time used?
ramping is used to produce a "soft start," allowing patients to become accustomed to the stimulation as it increases to reach motor threshold

the ramp up time is generally included in the on time while the ramp down time is generally included in the off time

ramp up and ramp down time are different from rise and decay time; the latter describe the time for the current amplitude to increase and decrease during a phase.
What is rise time/decay time?
rise time is the time it takes for the current to increase from zero to its peak during any one phase

decay time is the time it takes for the current to decrease from its peak level to zero during any one phase

note that this is different from ramp up/ramp down time
What is wavelength?
the duration of 1 cycle of AC

a cycle lasts from the time the current departs from the isoelectric line (zero current amplitude) in one direction and then crosses the isoelectric line in the opposite direction to when it returns to the isoelectric line

the wavelength of alternating current is similar to the pulse duration of pulsed current
What is amplitude (intensity)?
the magnitude of current or voltage
What is amplitude modulation?
variation in peak current amplitude over time
What is burst mode?
a current composed of series of pulses delivered in groups known as bursts

the burst is generally delivered with a preset frequency and duration

burst duration is the time from the beginning to the end of the burst

the time between bursts is called the interburst interval

PD/PW = 200 – 300 microsec (HIGH)
A = local motor contraction
F/R = 1 – 10 bps (LOW)
Time = approx. 30 min.

for acute and chronic pain, but primarily chronic because producing a contraction and a long pulse duration would likely be too uncomfortable for acute pain
What is frequency modulation?
variation in the number of pulses or cycles per second delivered
What is modulation?
any pattern of variation in one or more of the stimulation parameters

modulation is used to limit neural adaptation to an electrical current and may be cyclic or random
What is phase duration or pulse duration modulation?
variation in the phase or pulse duration
What is scan?
amplitude modulation of an interferential current

amplitude modulation of an interferential current moves the effective field of stimulation, causing the patient to feel the focus of the stimulation in a different location

this may allow the clinician to target a specific area in soft tissue.
What is sweep?
the frequency modulation of an interferential current
What is the absolute refractory period?
the period of time immediately after nerve depolarization when no action potential can be generated and nerve cannot be further excited, regardless of strength of stimulus
What is accommodation?
a transient increase in threshold to nerve excitation
What is an action potential?
the rapid sequential depolarization and repolarization of a nerve that occurs in response to a stimulus and transmits along the axon
What is adaptation?
a decrease in the frequency of action potentials and a decrease in the subjective sensation of stimulation that occurs in response to electrical stimulation with unchanging characteristics
What is chronaxie?
the minimum DURATION an electrical current at twice rheobase intensity needs to be applied to produce an action potential
What is depolarization?
the reversal of the resting potential in excitable cell membranes, where the inside of the cell becomes positive relative to the outside
What is myelin?
a fatty tissue that surrounds the axons of neurons, allowing electrical signals to travel more quickly
What are Nodes of Ranvier?
small, unmyelinated gaps in the myelin sheath covering myelinated axons
What is propagation?
the movement of an action potential along a nerve axon

also called conduction
What is the relative refractory period?
the period after nerve depolarization in which the nerve membrane is hyperpolarized, and a greater stimulus than usual is required to produce an action potential
What is resting membrane potential?
the electrical difference between the inside of a neuron and the outside when the neuron is at rest, usually 60-90 mV, with the inside being negative relative to the outside
What is rheobase?
the minimum current amplitude, with a long pulse duration, required to produce an action potential
What is saltatory conduction?
the rapid propagation of an electrical signal along a myelinated nerve axon, with the signal appearing to jump from one node of Ranvier to the next
Clinical applications for electrical stimulation in rehabilitation
- muscle strengthening
- muscle reeducation
- pain control
- facilitating healing of recalcitrant wounds
- resolving edema and inflammatory reactions after injury or surgery
- enhancing transdermal drug delivery
What is the message unit of the nervous system?
the action potential
For most applications, how does electrical current exert physiological effects?
by depolarizing nerve membranes and producing action potentials
With sufficient amplitude (rheobase) and duration (chronaxie) will cause enough of a change in
nerve membrane potential to generate an action potential
How is resting membrane potential maintained?
by most of the sodium ions (Na+) being outside the cell and most of the potassium (K+) ions being inside the cell
Strength-duration curve (easiest to most resistant)
minimum combination of amplitude (rheobase) and pulse duration (chronaxie) needed to depolarize a nerve

- Aβ sensory
- motor
- Aδ sharp pain
- C dull pain
- denervated muscle
Average pulse duration for sensory stimulation? Muscle contraction?
short (less than 80 μsec)

longer (150 to 350 μsec, unless for smaller muscles or treating a child/frail elderly, then 125 to 250 μsec likely to be more comfortable and better tolerated)
By keeping pulse durations under 1 ms at all times, pain is minimized because
C fibers are not depolarized

(1.0 ms seems to be pulse duration threshold for depolarization of C fibers)
How much of a pulse duration is needed to produce contractions of denervated muscle where the stimulus directly depolarizes the muscle cell rather than the motor nerve?
about 10 ms or more
Why is stimulation of denervated muscle generally uncomfortable?
since the pulse duration for depolarization of denervated muscle is 10ms or more, you've already passed the thresholds for stimulating C fibers (1 ms) and Aδ fibers (150 μsec)
Will increasing the current amplitude or pulse duration beyond threshold to stimulate action potential have any effect?
no, action potentials are all-or-none

increasing a parameter produces the same action potential, it cannot become larger or longer
In addition to sufficient current amplitude and pulse duration, the current amplitude must rise quickly to produce an action potential. What can happen if it does not?
accommodation occurs due to the prolonged subthreshold stimulation
Contrast action potential propagation with electrical stimulation and natural physiological stimulation.
generally, with physiological stimulation, action potentials propagate in only one direction

with electrically stimulated action potentials propagation occurs in both directions from the site of stimulation, however, only those action potentials transmitted in the "usual" physiological direction actually have an effect
The speed of propagation of an action potential depends upon:
- diameter of the nerve (thicker = faster)

- myelination (myelinated = faster)
Does denervated muscle tissue accommodate to stimuli?
no
What types of currents produce a net charge in tissue?
- DC
- pulsed monophasic currents
- unbalanced biphasic waveforms
Contrast electrically stimulated muscle contractions with physiologically initiated muscle contractions.
electrically stimulated muscle contractions recruit larger, fast-twitch muscle fibers first; these fatigue rapidly and atrophy quickly with disuse; contractions are also jerkier because all motor units of a given size fire simultaneously when stimulated

physiologically initiated muscle contractions recruit smaller, slow-twitch muscle fibers first; these are more fatigue- and atrophy-resistant; contractions are also smoother because of asynchronous recruitment of motor units
What can patients do to optimize funcitonal integration of strength gains with electrical stimulation?
for best results, patients should conduct physiological contractions in conjunction with the electrical stimulation
What should also be included in therapy with electrical stimulation of muscle contractions?
long rest times, since the recruitment first of larger, fast-twitch muscle fibers is fatiguing
By what two mechanisms is electrical stimulation thought to strengthen muscles?
- overload principle

- specificity theory
With electrically stimulated muscle contractions, by what means is force primarily increased? What limits this increase?
- force is primarily increased by increasing the total amount of current

- this is limited by patient tolerance and fatigue
How does changing the on:off cycle affect force of muscle contraction?
stronger contractions are produced when longer off times are used
What does the specificity theory state?
because ES recruits larger, fast-twitch muscles that produce a greater level of force to contract, ES should have more effect on these fibers than the slow-twitch fibers

in weak patients in whom there is generally primarily fast-twitch muscle atrophy, early use of ES can result in more rapid functional recovery and greater strength gains than exercise alone
To produce strength gains in healthy muscle, force of stimulated contraction must be at least
50% of maximum voluntary isometric contraction (MVIC)
What MVIC level has been effective in injured patients?
10%

but the stronger the better; the greatest strength gains are seen with the maximally tolerated force of contraction
To increase strength

To increase endurance
- higher force contractions

- prolonged stimulation with more lower-force contractions
How can ES be used to help patients with CNS damage?
if peripheral motor nerves are intact, NMES of lower extremities can
- improve voluntary recruitment of motor units and gait
- increase ankle dorsiflexion torque
- reduce agonist:antagonist cocontraction
How can NMES help with joint positioning?
it can be used to reduce glenohumeral separation and shoulder subluxation in stroke patients with hemiplegia
Though traditionally ES has been used for limbs, what other uses is it finding?
- helping with dysphagia, particularly following stroke

- urinary incontinence associated with pelvic floor disfunction (but also stress, urge and mixed incontinence)

- improved circulation, reduction of DVT
What type of ES is used to provoke contraction in denervated muscle?
continuous DC (of 10 ms or more regulated manually)

although since there is controversy about whether this retards motor nerve regeneration, it is not currently recommended by most
Denervation causes muscles to
atrophy and fibrose
How are electrodes placed when ES is applied to produce muscle contraction?
- one electrode over motor point

- other placed on the muscle so the two electrodes are parallel to direction of muscle fibers

should be at least 2 inches apart to avoid them becoming too close (less than 1 inch apart) when the muscle contracts
What is the motor point?
the place where an electrical stimulus will produce the greatest contraction with the least amount of electricity

area of skin over which the motor nerve enters the muscle

generally, most motor points are over the middle of the muscle belly
What waveform should be used when ES is used to produce muscle contractions?
- pulsed biphasic waveform
or
- Russian protocol
When using ES to produce muscle contraction in innervated muscle, what should the pulse duration be?
between 150 and 350 μsec
Which do patients generally find more comfortable, longer or shorter pulse durations?
shorter for smaller muscles

longer for larger muscles

smaller people and children often find shorter durations more comfortable as well
What adjustments must be made when using a shorter pulse duration?
a greater amplitude is needed to achieve the same strength of contraction
How does the clinician decide on the best pulse duration and current amplitude for producing muscle contraction?
base on patient comfort and achievement of the desired outcome
Pulse frequency determines
type of response or muscle contraction produced
Low frequency of less than 30 pps will produce
twitch
As frequency increases, twitches move closer together, eventually producing smooth, tetanic contraction. What frequency is required?
35 to 50 pps
What happens when frequency is increased beyond 50-80 pps
greater muscle strengthening, but

also more rapid fatigue
On:off recommendation for muscle strengthening ES
on - 6-10 seconds
off - 50-120 seconds

start at 1:5 to minimize fatigue,
work to 1:4 or 1:3
On:off recommendation to reduce spasm or pump out edema
spasm - 2-5 seconds at 1:1 to fatigue the muscle and relax the spasm

edema - also 2-5 seconds at 1:1
Pulse frequency for
- muscle strengthening
- muscle reeducation
- muscle spasm reduction
- edema reduction using muscle pump
- 35-80 pps
- 35-50 pps
- 35-50 pps
- 35-50 pps
Pulse duration for
- muscle strengthening
- muscle reeducation
- muscle spasm reduction
- edema reduction using muscle pump
150-200 μsec for small muscles
200-350 μsec for large muscles

for all purposes
Amplitude for
- muscle strengthening
- muscle reeducation
- muscle spasm reduction
- edema reduction using muscle pump
- to >10% MVIC if injured; >50% if uninjured
- sufficient for functional activity
- to visible contraction
- to visible contraction
On:off times/ratios for
- muscle strengthening
- muscle reeducation
- muscle spasm reduction
- edema reduction using muscle pump
- 6-10 sec on; 50-120 sec off and ratio of 1:5, progressing to 1:4 or 1:3
- depends on functional activity
- 2-5 sec each in 1:1 ratio
- 2-5 sec each in 1:1 ratio
Ramp times for
- muscle strengthening
- muscle reeducation
- muscle spasm reduction
- edema reduction using muscle pump
- at least 2 seconds
- at least 2 seconds
- at least 1 second
- at least 1 second
Treatment time for
- muscle strengthening
- muscle reeducation
- muscle spasm reduction
- edema reduction using muscle pump
- 10-20 minutes to produce 10-20 reps
- depends on functional activity
- 10-30 minutes
- 30 minutes
Times per day tx for
- muscle strengthening
- muscle reeducation
- muscle spasm reduction
- edema reduction using muscle pump
- every 2-3 hours when awake
- NA
- every 2-3 hours until spasm relieved
- twice daily
A-beta nerves can be activated by both short- and long-duration electrical current pulses, but why are short-duration pulses better?
short-duration pulses (between 50-80 μsec) and a comfortable current amplitude selectively activate these nerves without activating motor nerves
How can conventional TENS interrupt the pain-spasm-pain cycle?
pain reduction continues (slightly) after treatment stops, this keeps spasms from returning, further reducing pain
Why is the stimulus used for conventional TENS generally modulated?
to limit adaptation

(decrease in the frequency of action potentials and decrease in subjective sensation of stimulation)

nerve membrane exhibits decreased excitability with repeated stimulation
How do endogenous opioids (endorphins and enkephalins) modulate pain perception?
- they work similarly to morphine

- they bind to opiate receptors in the brain and act as neurotransmitters and neuromodulators

- they activate descending inhibitory pathways that involve nonopioid (serotonin) systems
How can TENS be used to stimulate endogenous opiod production and release?
repetitive stimulation of motor or nociceptive A-delta nerves to produce repetitive muscle contractions or brief, sharp pain can stimulate their production and release

- use longer pulsed durations, higher amplitudes, and lower frequencies (2-10 pps) than those used for conventional TENS (Low-rate/acupuncture-like)
How long will low-rate/acupuncture-like TENS control pain after treatment?
4-5 hours after a 20-30 minute treatment
Why should low-rate/acupuncture-like TENS not be applied for more than 45 minutes?
it can result in delayed-onset muscle soreness (DOMS)
Electrode placement for ES for pain control
if 2 channels/4 electrodes
- surround pain
- may intersect channels to allow current to cross at area of pain
- may place channels parallel, either vertically or horizontally

if 1 channel/2 electrodes
- place around the painful area
- place over trigger or acupuncture points
- if can't place near or over painful area, place proximal to the site of pain along the pathway of the sensory nerves supplying the area
Waveform for ES for pain control
- pulsed biphasic (requires only 2 electrodes), or
- interferential (may be more comfortable, affect a larger area, and provide longer-lasting effects)
When using IFC for pain control, what pulse duration is used?
trick question!

IFC uses AC, so wavelength/frequency altered, not pulse

CF 2500 Hz - wavelength 400 μsec
CF 4000 Hz - wavelength 250 μsec
CF 5000 Hz - wavelength 200 μsec
What is the fixed carrier frequency for most IFC units?
4,000 or 5,000 Hz
Pulse frequency (or beat frequency for interferential) for
- conventional (high rate)
- acupuncture-like (low rate)
- burst mode
- 100-150 pps
- 2-10 pps
- generally preset in unit at 10 bursts
Pulse duration for
- conventional (high rate)
- acupuncture-like (low rate)
- burst mode
- 50-80 μsec
- 200-300 μsec
- generally preset and may have max of 100-300 μsec
Amplitude for
- conventional (high rate)
- acupuncture-like (low rate)
- burst mode
- to produce tingling
- to visible contraction
- to visible contraction
Modulation for
- conventional (high rate)
- acupuncture-like (low rate)
- burst mode
- use if available
- none
- generally not possible
Treatment time for
- conventional (high rate)
- acupuncture-like (low rate)
- burst mode
- may be worn 24 hours as needed for pain control
- 20-45 minutes every 4 hours
- 20-45 minutes every 4 hours
Possible mechanism of action for
- conventional (high rate)
- acupuncture-like (low rate)
- burst mode
- gating at spinal cord
- endorphin release
- endorphin release
ES aids wound healing, particularly in conjunction with
standard wound care
What mechanisms are proposed to explain how ES aids wound healing?
- increased protein synthesis and cell migration
- antibacterial effects
- increased blood flow
- improved tissue oxygenation
- attraction of appropriate cell types to area
- activation of these cells by altering cell membrane function
- modification of endogenous electrical potential of the tissue in concert with healing potentials
- reduction of edema
- enhancement of antimicrobial activity
- promotion of circulation
For what type of wound has ES been found to work best?
ES has been found most effective for accelerating healing of pressure ulcers
To which pole are the following attracted:
- activated neutrophils
- inactive neutrophils
- macrophages
- epidermal cells
- lymphocytes
- platelets
- mast cells
- keratinocytes
- fibroblasts
- activated neutrophils (-)
- inactive neutrophils (+)
- macrophages (+)
- epidermal cells(+)
- lymphocytes (-)
- platelets (-)
- mast cells (-)
- keratinocytes (-)
- fibroblasts (-)
What electrode is used to treat inflamed, infected or acute (first 3-7 days) wounds?
negative (cathode)
What electrode is used to treat wounds with necrosis without inflammation and during the proliferative stage of healing?
positive (anode)
What types of ES have been shown to kill bacteria?
- DC
- HVPC

(but it is likely that to inhibit bacterial growth, electrical currents must be applied either at much higher voltages or for much longer times than used in clinical settings)
Electrode placement for wound healing
- in or around the wound

- one electrode used if inside wound (saline-soaked gauze, surrounded by tin foil and hooked to alligator clip)

- two or more electrodes used if around wound
Specifications for size/placement of dispersive electrode for wound healing
large

opposite polarity to treatment electrode

placed on intact skin close to wound site
Waveform for wound healing ES
mainly HVPC

LIDC also found effective
Polarity for wound healing ES
- negative for infection/inflammation or first 3-7 days of treatment

- positive thereafter if no inflammation/infection

some recommend using negative for all treatments or switching polarity when treatment reaches a plateau
Recommended pulse duration for HVPC for wound healing
- 40-100 μsec (generally preset in device)
Recommended frequency for HVPC for wound healing
60-125 pps
On:off time for HVPC for wound healing
trick question

none, it's continuous
Current amplitude for HVPC for wound healing
to produce comfortable tingling without motor response
What can the clinician do to determine appropriate amplitude for HVPC treatment for wound healing if the individual has reduced sensation in the area of the wound?
find the appropriate amplitude by applying the electrode to another area with intact sensation (e.g., the other ankle)
Treatment time and frequency for HVPC for wound healing
45-60 minutes per day
at least 5 days per week
Types of edema for which ES may be used
- inflammation (red/hot) use negative electrode, submotor HVPC

- poor circulation (pale, cold) use motor level (need pump)
What can ES do for edema caused by inflammatory response
it can retard formation of edema, but cannot reduce the amount already present
Theories for ES/HVPC retardation of edema formation associated with inflammation
- negative charge repels negatively charged serum proteins
- decreases blood flow by reducing microvessel diameter
- reduction in pore size in microvessel walls, preventing large plasma protein from leaking through
Waveform used for ES treatment of edema associated with
- inflammation
- poor circulation, lack of motion
- HVPC
- pulsed biphasic (can use interferential if on:off time is available) or Russian protocol
Can ES be used to treat edema caused by kidney failure?
no

only for edema caused by inflammation or by poor circulation/lack of movement, not for other causes
Electrode placement for HVPC treatment for retarding formation of edema due to inflammation
- negative electrode directly over the edema

- dispersive electrode more proximal
Electrode placement for treating edema due to lack of muscle contraction/disuse
- place electrodes on the muscle around the main veins draining the area

- same way as recommended for muscle contractions
Polarity used for ES treatment of edema associated with
- inflammation
- poor circulation, lack of motion
- negative

- NA
Pulse frequency used for ES treatment of edema associated with
- inflammation
- poor circulation, lack of motion
- 100-120 pps

- 35-50 pps with 2-5 (1-2) second 1:1 on:off times
Pulse duration used for ES treatment of edema associated with
- inflammation
- poor circulation, lack of motion
- usually preset for HVPC at 40-100 μsec

- 150-350 μsec
Amplitude used for ES treatment of edema associated with
- inflammation
- poor circulation, lack of motion
- to produce comfortable tingling

- to visible contraction
Treatment time used for ES treatment of edema associated with
- inflammation
- poor circulation, lack of motion
- 20-30 minutes, may be used more than once per day

- 20-30 minutes, may be used more than once per day
Theories on how iontophoresis works
- like charges repel and drive medication through skin

- may increase permeability of stratum corneum, the main barrier to transdermal drug uptake
What causes declining drug concentration with distance?
possibly clearance from the site of application by skin's microcirculation, resulting in systemic uptake of the drug
What is required to facilitate transdermal drug penetration?
the current must be at least sufficient to overcome the combined resistance of the skin and electrode being used
What is the most common iontohoresis treatment (mA-min)?
40 mA-min

some have 80 mA-min, however
How is amplitude set for iontophoresis delivery?
- to patient comfort (1-4 mA)

- then adjust time to produce the desired result (40, 20, 13.3, 10 mins)
What can happen under the negative electrode during iontophoresis?
sodium hydroxide can form and cause discomfort, skin irritation, or chemical burns (alkaline reaction)
How can the clinician reduce the likelihood of an alkaline reaction during iontophoresis?
reduce the current density

(either by increasing the size of the negative electrode or reducing the current amplitude)
What can happen under the positive electrode during iontophoresis?
hydrochloric acid can form (acidic reaction)

this is generally less uncomfortable than the alkaline reaction
What is dexamethasone?
corticosteroid with anti-inflammatory properties recommended for treatment of inflammatory conditions such as tendonitis or bursitis
What is lidocaine?
an anesthetic drug
How are electrodes placed for iontophoresis?
delivery electrode over the area of pathology, dispersive or return electrode a few inches away, at a site of convenience over a large muscle belly
The electrodes should be large enough that their current densities do not exceed
0.5 mA/cm sq (cathode delivery)

1.0 mA/cm sq (anode delivery)
Why should use of ES over open or damaged skin (except when treating the wound) be avoided?
open or damaged skin has lower impedance and less sensation than intact skin and this may result in too much current being delivered to the area
Why should iontophoresis not be applied after the application of another modality that may alter skin permeability?
heat, ice, ultrasound, etc. alter skin permeability

heat will cause vasodilation and increased blood flow that can accelerate dispersion of the drug
How can the risk of burns be minimized with IFC?
use at least 2 X 2 inch electrodes and only electrodes that adhere well to skin
Why may poor adhesion of electrodes cause burns?
because the current density then increases in portions of the electrode that are sticking and can cause burns
When applying ES for muscle strengthening, why should the limb be secured?
to prevent motion through the range

you want the joint in midrange where the patient can perform a strong isometric contraction, rather than having them move through the ROM and applying maximum force at the end of the ROM
Upon what does selection of electrode depend?
- desired size, shape, and type
- treatment goals
- area to be treated
- amount of tissue or bulk targeted
Current density is inversely proporational to
size of electrode

thus larger electrodes are more comfortable, but cannot target small areas
Why shouldn't electrodes be placed over bony prominences?
- higher resistance of bone
- poor adhesion of electrodes to highly contoured surfaces

increases risk of burns and is less likely to produce therapeutic benefits