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15 Cards in this Set
- Front
- Back
Depolarization
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1. resting state is -70
2. NA+ into cell leads to positive charge=-60, cell gets excited (membrane altered) and fires 3. this is action potential=firing = NT release.(glutemate) 4. Excitatory |
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hyperpolarization
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1. CL- goes into cell, inhibitory, cell goes fr0m -70 to -90, will not fires. GABA (barbs)
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Synapses kinds
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excitatory and inhibitory
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GABA
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inhibitory, in 75-90 percent of brain cells
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Glutemate
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Excitatory in 75-90 percent of brain cells
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5HT
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Indole amine, from trypotophan makes you feel good, in 10 percent of brain cells
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NE and DA
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Catecholamines, from Tyrosine to L dopa to Dopa to DA to NE.
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ACh
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REsponsible for anticholinergic side effects caused by tricylics and antipsycotics (conventional)
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Reuptake
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NT is removed right after it exerts its effect on post synaptic membrane. Reuptake transport pump removes and deactinvates. Most common method of deactivating.
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SSRI's
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Prozac paxil, zoloft. (also lexapro and celexa)--sexual side effects, decrease orgasm decrease drive,(headache, sleepy, nervous)
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SNRI's
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1. NRI--walbuterin/zyban-no sexual side effect
2. SNRI-Effexor, Remrone and SEzone (cymbalta) In low doses affect 5ht, middle doses 5HT and NE high doses also DA. |
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Seraotonin-why not prescribed
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does not ex the Blood Brain Barrier.
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Prozac
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5 day half life, not a big problem to miss one, arousing give to letghargic patient
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Zoloft
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12 hour half life, can't miss a dose but can give drug holiday, arousing, give to lethargic patient
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Paxil
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Sedating, give to imsomniac patient
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